Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection

How helminths influence the pathogenesis of sexually transmitted viral infections is not comprehensively understood. Here, we show that an acute helminth infection (Nippostrongylus brasiliensis [Nb]) induced a type 2 immune profile in the female genital tract (FGT). This leads to heightened epitheli...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell host & microbe 2021-04, Vol.29 (4), p.579-593.e5
Hauptverfasser:	Chetty, Alisha, Darby, Matthew G., Vornewald, Pia M., Martín-Alonso, Mara, Filz, Anna, Ritter, Manuel, McSorley, Henry J., Masson, Lindi, Smith, Katherine, Brombacher, Frank, O’Shea, Matthew K., Cunningham, Adam F., Ryffel, Bernhard, Oudhoff, Menno J., Dewals, Benjamin G., Layland, Laura E., Horsnell, William G.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals eosinophils Eosinophils - immunology Eosinophils - pathology epithelial ulceration Female Helminthiasis - complications Helminthiasis - immunology Helminths Herpes Simplex - complications Herpes Simplex - immunology Herpes Simplex - pathology Herpes Simplex - virology Herpesvirus 2, Human - immunology HSV-2 Human health sciences IL-33 IL-5 Immunity Immunologie & maladie infectieuse Immunology & infectious disease Interleukin-33 Interleukin-5 Necrosis Nippostrongylus Nippostrongylus brasiliensis Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Sciences de la santé humaine systemic immunity vagina Vagina - immunology Vagina - pathology Vagina - virology Vaginal Diseases - immunology Vaginal Diseases - parasitology Vaginal Diseases - virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!