Incidence of COVID-19 recurrence among large cohort of healthcare employees
To quantify COVID-19 recurrence among clinical and nonclinical healthcare employees with SARS-CoV-2 IgG antibodies or prior COVID-19 infection. This prospective, cohort study collected and resulted SARS-CoV-2 IgG serum samples as positive or negative from June 8 to July 10, 2020 from a convenience s...
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| Veröffentlicht in: | Annals of epidemiology 2021-08, Vol.60, p.8-14 |
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| container_title | Annals of epidemiology |
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| creator | Veronica, Fitzpatrick Anne, Rivelli Christopher, Blair Kenneth, Copeland Jon, Richards |
| description | To quantify COVID-19 recurrence among clinical and nonclinical healthcare employees with SARS-CoV-2 IgG antibodies or prior COVID-19 infection.
This prospective, cohort study collected and resulted SARS-CoV-2 IgG serum samples as positive or negative from June 8 to July 10, 2020 from a convenience sample of 16,233 adult participants employed by a large Midwestern healthcare system. Documented positive polymerase chain reaction test results representing COVID-19 infections were recorded up to four months prior to and post-IgG testing.
Nine hundred and thirteen (6.12%) participants, including 45 (4.93%) IgG positive participants, experienced COVID-19 infections after study initiation, representing a 51% increased risk of COVID-19 infection among IgG positive participants (IRR = 1.51). Regressions adjusted for documented disparities showed no difference in COVID-19 infection by IgG status (OR=1.19; P = .3117) but significantly greater odds in COVID-19 recurrence among participants with a prior documented COVID-19 infection (OR=1.93; P < .0001).
SARS-CoV-2 IgG antibodies and prior COVID-19 infection do not appear to offer meaningful protection against COVID-19 recurrence in healthcare workers. Recurrence would impact decisions regarding ongoing healthcare resource utilization. This study can inform considerations for vaccine administration to vulnerable groups. |
| doi_str_mv | 10.1016/j.annepidem.2021.04.005 |
| format | Article |
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This prospective, cohort study collected and resulted SARS-CoV-2 IgG serum samples as positive or negative from June 8 to July 10, 2020 from a convenience sample of 16,233 adult participants employed by a large Midwestern healthcare system. Documented positive polymerase chain reaction test results representing COVID-19 infections were recorded up to four months prior to and post-IgG testing.
Nine hundred and thirteen (6.12%) participants, including 45 (4.93%) IgG positive participants, experienced COVID-19 infections after study initiation, representing a 51% increased risk of COVID-19 infection among IgG positive participants (IRR = 1.51). Regressions adjusted for documented disparities showed no difference in COVID-19 infection by IgG status (OR=1.19; P = .3117) but significantly greater odds in COVID-19 recurrence among participants with a prior documented COVID-19 infection (OR=1.93; P < .0001).
SARS-CoV-2 IgG antibodies and prior COVID-19 infection do not appear to offer meaningful protection against COVID-19 recurrence in healthcare workers. Recurrence would impact decisions regarding ongoing healthcare resource utilization. This study can inform considerations for vaccine administration to vulnerable groups.</description><identifier>ISSN: 1047-2797</identifier><identifier>ISSN: 1873-2585</identifier><identifier>EISSN: 1873-2585</identifier><identifier>DOI: 10.1016/j.annepidem.2021.04.005</identifier><identifier>PMID: 33895245</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Antibodies, Viral ; Cohort Studies ; COVID-19 ; Delivery of Health Care ; Epidemiology ; Health Personnel ; Humans ; Incidence ; Infectious diseases ; Original ; Prospective Studies ; SARS-CoV-2</subject><ispartof>Annals of epidemiology, 2021-08, Vol.60, p.8-14</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Inc.</rights><rights>2021 Elsevier Inc. All rights reserved. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-a1e5612440adb952283b17f8382df411c6d193eca5c459d490953e0ff20437293</citedby><cites>FETCH-LOGICAL-c475t-a1e5612440adb952283b17f8382df411c6d193eca5c459d490953e0ff20437293</cites><orcidid>0000-0002-0509-3475 ; 0000-0001-8676-5546</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1047279721000612$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33895245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veronica, Fitzpatrick</creatorcontrib><creatorcontrib>Anne, Rivelli</creatorcontrib><creatorcontrib>Christopher, Blair</creatorcontrib><creatorcontrib>Kenneth, Copeland</creatorcontrib><creatorcontrib>Jon, Richards</creatorcontrib><title>Incidence of COVID-19 recurrence among large cohort of healthcare employees</title><title>Annals of epidemiology</title><addtitle>Ann Epidemiol</addtitle><description>To quantify COVID-19 recurrence among clinical and nonclinical healthcare employees with SARS-CoV-2 IgG antibodies or prior COVID-19 infection.
This prospective, cohort study collected and resulted SARS-CoV-2 IgG serum samples as positive or negative from June 8 to July 10, 2020 from a convenience sample of 16,233 adult participants employed by a large Midwestern healthcare system. Documented positive polymerase chain reaction test results representing COVID-19 infections were recorded up to four months prior to and post-IgG testing.
Nine hundred and thirteen (6.12%) participants, including 45 (4.93%) IgG positive participants, experienced COVID-19 infections after study initiation, representing a 51% increased risk of COVID-19 infection among IgG positive participants (IRR = 1.51). Regressions adjusted for documented disparities showed no difference in COVID-19 infection by IgG status (OR=1.19; P = .3117) but significantly greater odds in COVID-19 recurrence among participants with a prior documented COVID-19 infection (OR=1.93; P < .0001).
SARS-CoV-2 IgG antibodies and prior COVID-19 infection do not appear to offer meaningful protection against COVID-19 recurrence in healthcare workers. Recurrence would impact decisions regarding ongoing healthcare resource utilization. This study can inform considerations for vaccine administration to vulnerable groups.</description><subject>Adult</subject><subject>Antibodies, Viral</subject><subject>Cohort Studies</subject><subject>COVID-19</subject><subject>Delivery of Health Care</subject><subject>Epidemiology</subject><subject>Health Personnel</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Original</subject><subject>Prospective Studies</subject><subject>SARS-CoV-2</subject><issn>1047-2797</issn><issn>1873-2585</issn><issn>1873-2585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu2zAQRYkiRfNof6HVMhspw5dJbQIEbh5GA2TTdkvQ1MimIYkOKQfI35eKUyNZZTXE8M6dwbmE_KBQUaCzi01lhwG3vsG-YsBoBaICkJ_ICdWKl0xqeZTfIFTJVK2OyWlKGwBQWrEv5JhzXUsm5An5tRhcdhkcFqEt5g9_Fz9LWhcR3S7Gl7btw7AqOhtXWLiwDnGclGu03bh2NmKB_bYLz4jpK_nc2i7ht9d6Rv7cXP-e35X3D7eL-dV96YSSY2kpyhllQoBtlvkMpvmSqlZzzZpWUOpmDa05OiudkHUjaqglR2hbBoIrVvMzcrn33e6WPTYOhzHazmyj7218NsF68_5n8GuzCk9Gw4wqLbLB-atBDI87TKPpfXLYdXbAsEuGyUyRTZCyVO2lLoaUIraHNRTMFIXZmEMUZorCgDA5ijz5_e2Vh7n_7LPgai_AzOrJYzTJ-Ql54zP-0TTBf7jkH7Lnnl0</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Veronica, Fitzpatrick</creator><creator>Anne, Rivelli</creator><creator>Christopher, Blair</creator><creator>Kenneth, Copeland</creator><creator>Jon, Richards</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0509-3475</orcidid><orcidid>https://orcid.org/0000-0001-8676-5546</orcidid></search><sort><creationdate>20210801</creationdate><title>Incidence of COVID-19 recurrence among large cohort of healthcare employees</title><author>Veronica, Fitzpatrick ; Anne, Rivelli ; Christopher, Blair ; Kenneth, Copeland ; Jon, Richards</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-a1e5612440adb952283b17f8382df411c6d193eca5c459d490953e0ff20437293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Antibodies, Viral</topic><topic>Cohort Studies</topic><topic>COVID-19</topic><topic>Delivery of Health Care</topic><topic>Epidemiology</topic><topic>Health Personnel</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Original</topic><topic>Prospective Studies</topic><topic>SARS-CoV-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Veronica, Fitzpatrick</creatorcontrib><creatorcontrib>Anne, Rivelli</creatorcontrib><creatorcontrib>Christopher, Blair</creatorcontrib><creatorcontrib>Kenneth, Copeland</creatorcontrib><creatorcontrib>Jon, Richards</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veronica, Fitzpatrick</au><au>Anne, Rivelli</au><au>Christopher, Blair</au><au>Kenneth, Copeland</au><au>Jon, Richards</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of COVID-19 recurrence among large cohort of healthcare employees</atitle><jtitle>Annals of epidemiology</jtitle><addtitle>Ann Epidemiol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>60</volume><spage>8</spage><epage>14</epage><pages>8-14</pages><issn>1047-2797</issn><issn>1873-2585</issn><eissn>1873-2585</eissn><abstract>To quantify COVID-19 recurrence among clinical and nonclinical healthcare employees with SARS-CoV-2 IgG antibodies or prior COVID-19 infection.
This prospective, cohort study collected and resulted SARS-CoV-2 IgG serum samples as positive or negative from June 8 to July 10, 2020 from a convenience sample of 16,233 adult participants employed by a large Midwestern healthcare system. Documented positive polymerase chain reaction test results representing COVID-19 infections were recorded up to four months prior to and post-IgG testing.
Nine hundred and thirteen (6.12%) participants, including 45 (4.93%) IgG positive participants, experienced COVID-19 infections after study initiation, representing a 51% increased risk of COVID-19 infection among IgG positive participants (IRR = 1.51). Regressions adjusted for documented disparities showed no difference in COVID-19 infection by IgG status (OR=1.19; P = .3117) but significantly greater odds in COVID-19 recurrence among participants with a prior documented COVID-19 infection (OR=1.93; P < .0001).
SARS-CoV-2 IgG antibodies and prior COVID-19 infection do not appear to offer meaningful protection against COVID-19 recurrence in healthcare workers. Recurrence would impact decisions regarding ongoing healthcare resource utilization. This study can inform considerations for vaccine administration to vulnerable groups.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33895245</pmid><doi>10.1016/j.annepidem.2021.04.005</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0509-3475</orcidid><orcidid>https://orcid.org/0000-0001-8676-5546</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of epidemiology, 2021-08, Vol.60, p.8-14 |
| issn | 1047-2797 1873-2585 1873-2585 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antibodies, Viral Cohort Studies COVID-19 Delivery of Health Care Epidemiology Health Personnel Humans Incidence Infectious diseases Original Prospective Studies SARS-CoV-2 |
| title | Incidence of COVID-19 recurrence among large cohort of healthcare employees |
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