Is the high-performance thermoplastic polyetheretherketone indicated as a clasp material for removable dental prostheses?
Objectives To investigate the retention force of polyetheretherketone (PEEK) removable dental prosthesis clasps in comparison with a cobalt-chrome-molybdenum control group after storage in artificial saliva. Materials and Methods Clasps were milled (Dentokeep (PEEKmilled1), NT digital implant techno...
Gespeichert in:
| Veröffentlicht in: | Clinical oral investigations 2021-05, Vol.25 (5), p.2859-2866 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2866 |
|---|---|
| container_issue | 5 |
| container_start_page | 2859 |
| container_title | Clinical oral investigations |
| container_volume | 25 |
| creator | Micovic, Danka Mayinger, Felicitas Bauer, Sebastian Roos, Malgorzata Eichberger, Marlis Stawarczyk, Bogna |
| description | Objectives
To investigate the retention force of polyetheretherketone (PEEK) removable dental prosthesis clasps in comparison with a cobalt-chrome-molybdenum control group after storage in artificial saliva.
Materials and Methods
Clasps were milled (Dentokeep (PEEKmilled1), NT digital implant technology; breCAM BioHPP Blank (PEEKmilled2), bredent), pressed (BioHPP Granulat for 2 press (PEEKpressed), bredent), or cast (remanium GM 800+ (cobalt-chrome-molybdenum), Dentaurum);
N
= 60,
n
= 15/subgroup. Retention force was examined 50 times/specimen in a pull-off test using the universal testing machine (Zwick 1445), where pull-off force was applied with a crosshead speed of 5 mm/minute until the maximum force dropped by 10%, at different aging levels: (1) initial, after storage in artificial saliva for (2) 90 and (3) 180 days. Statistical analysis was performed using one-way ANOVA followed by post hoc Scheffé-test and mixed models (
p
< 0.05).
Results
Cobalt-chrome-molybdenum presented the highest retention force. No differences were observed between polyetheretherketone materials. Cobalt-chrome-molybdenum showed a significant decrease of its values after artificial aging, while polyetheretherketone materials presented similar results over the course of aging. Regarding a repetitive insertion and removal, even though PEEKmilled2 and cobalt-chrome-molybdenum showed an initial increase, ultimately, a decrease in retention force was observed for all tested groups.
Conclusions
Although the control group showed significantly higher results, the retention force of polyetheretherketone materials indicate a potential clinical application. Neither the manufacturing process nor artificial aging showed an impact on the retention force of polyetheretherketone clasps.
Clinical relevance
Mechanical properties of novel removable dental prosthesis clasp materials devised to meet the growing esthetic demands of patients need to be investigated to ensure a successful long-term clinical application. |
| doi_str_mv | 10.1007/s00784-020-03603-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8060225</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2515944779</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-bd39dabeae6bf59673483d10288bc56dbc0dff6f9e0de6618a943e3cc73c5ca83</originalsourceid><addsrcrecordid>eNp9UU1v1DAQtRCItgt_gAOyxIWLwR-J41xAqKJQqRIXOFuOPdl1SeJgZyvl3zO7W8rHgcuM9ebNmxk_Ql4I_kZw3rwtGEzFuOSMK80VWx-Rc1EpzVTTiMfHt2S6NeKMXJRyy7modKOekjOluNS1VOdkvS502QHdxe2OzZD7lEc3eTiAeUzz4MoSPZ3TsMIBOobvsKQJaJxC9G6BQF2hjnrkznREIEc3UFSiGcZ057oBaIBpQXDOqaBCgfL-GXnSu6HA8_u8Id-uPn69_Mxuvny6vvxww3xd8YV1QbXBdeBAd33d4v6VUUFwaUznax06z0Pf674FHkBrYVxbKVDeN8rX3hm1Ie9OuvO-GyF4XCS7wc45ji6vNrlo_65McWe36c4arrmUNQq8vhfI6cceymLHWDwMg5sg7YuVVdUKI2ucuyGv_qHepn2e8Dwra4GMqmlaZMkTy-NvlAz9wzKC24Oz9uSsRWft0Vm7YtPLP894aPllJRLUiVCwNG0h_579H9mf9MizwQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2515944779</pqid></control><display><type>article</type><title>Is the high-performance thermoplastic polyetheretherketone indicated as a clasp material for removable dental prostheses?</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Micovic, Danka ; Mayinger, Felicitas ; Bauer, Sebastian ; Roos, Malgorzata ; Eichberger, Marlis ; Stawarczyk, Bogna</creator><creatorcontrib>Micovic, Danka ; Mayinger, Felicitas ; Bauer, Sebastian ; Roos, Malgorzata ; Eichberger, Marlis ; Stawarczyk, Bogna</creatorcontrib><description>Objectives
To investigate the retention force of polyetheretherketone (PEEK) removable dental prosthesis clasps in comparison with a cobalt-chrome-molybdenum control group after storage in artificial saliva.
Materials and Methods
Clasps were milled (Dentokeep (PEEKmilled1), NT digital implant technology; breCAM BioHPP Blank (PEEKmilled2), bredent), pressed (BioHPP Granulat for 2 press (PEEKpressed), bredent), or cast (remanium GM 800+ (cobalt-chrome-molybdenum), Dentaurum);
N
= 60,
n
= 15/subgroup. Retention force was examined 50 times/specimen in a pull-off test using the universal testing machine (Zwick 1445), where pull-off force was applied with a crosshead speed of 5 mm/minute until the maximum force dropped by 10%, at different aging levels: (1) initial, after storage in artificial saliva for (2) 90 and (3) 180 days. Statistical analysis was performed using one-way ANOVA followed by post hoc Scheffé-test and mixed models (
p
< 0.05).
Results
Cobalt-chrome-molybdenum presented the highest retention force. No differences were observed between polyetheretherketone materials. Cobalt-chrome-molybdenum showed a significant decrease of its values after artificial aging, while polyetheretherketone materials presented similar results over the course of aging. Regarding a repetitive insertion and removal, even though PEEKmilled2 and cobalt-chrome-molybdenum showed an initial increase, ultimately, a decrease in retention force was observed for all tested groups.
Conclusions
Although the control group showed significantly higher results, the retention force of polyetheretherketone materials indicate a potential clinical application. Neither the manufacturing process nor artificial aging showed an impact on the retention force of polyetheretherketone clasps.
Clinical relevance
Mechanical properties of novel removable dental prosthesis clasp materials devised to meet the growing esthetic demands of patients need to be investigated to ensure a successful long-term clinical application.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-020-03603-y</identifier><identifier>PMID: 33026523</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aging ; Chromium Alloys ; Cobalt ; Dental Clasps ; Dental Stress Analysis ; Dentistry ; Denture Retention ; Denture, Partial, Removable ; Esthetics, Dental ; Humans ; Ketones ; Materials Testing ; Mechanical properties ; Medicine ; Molybdenum ; Original ; Original Article ; Polyethylene Glycols ; Prostheses ; Prosthetics ; Retention ; Saliva ; Statistical analysis</subject><ispartof>Clinical oral investigations, 2021-05, Vol.25 (5), p.2859-2866</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-bd39dabeae6bf59673483d10288bc56dbc0dff6f9e0de6618a943e3cc73c5ca83</citedby><cites>FETCH-LOGICAL-c540t-bd39dabeae6bf59673483d10288bc56dbc0dff6f9e0de6618a943e3cc73c5ca83</cites><orcidid>0000-0003-0089-9995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-020-03603-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-020-03603-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33026523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Micovic, Danka</creatorcontrib><creatorcontrib>Mayinger, Felicitas</creatorcontrib><creatorcontrib>Bauer, Sebastian</creatorcontrib><creatorcontrib>Roos, Malgorzata</creatorcontrib><creatorcontrib>Eichberger, Marlis</creatorcontrib><creatorcontrib>Stawarczyk, Bogna</creatorcontrib><title>Is the high-performance thermoplastic polyetheretherketone indicated as a clasp material for removable dental prostheses?</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
To investigate the retention force of polyetheretherketone (PEEK) removable dental prosthesis clasps in comparison with a cobalt-chrome-molybdenum control group after storage in artificial saliva.
Materials and Methods
Clasps were milled (Dentokeep (PEEKmilled1), NT digital implant technology; breCAM BioHPP Blank (PEEKmilled2), bredent), pressed (BioHPP Granulat for 2 press (PEEKpressed), bredent), or cast (remanium GM 800+ (cobalt-chrome-molybdenum), Dentaurum);
N
= 60,
n
= 15/subgroup. Retention force was examined 50 times/specimen in a pull-off test using the universal testing machine (Zwick 1445), where pull-off force was applied with a crosshead speed of 5 mm/minute until the maximum force dropped by 10%, at different aging levels: (1) initial, after storage in artificial saliva for (2) 90 and (3) 180 days. Statistical analysis was performed using one-way ANOVA followed by post hoc Scheffé-test and mixed models (
p
< 0.05).
Results
Cobalt-chrome-molybdenum presented the highest retention force. No differences were observed between polyetheretherketone materials. Cobalt-chrome-molybdenum showed a significant decrease of its values after artificial aging, while polyetheretherketone materials presented similar results over the course of aging. Regarding a repetitive insertion and removal, even though PEEKmilled2 and cobalt-chrome-molybdenum showed an initial increase, ultimately, a decrease in retention force was observed for all tested groups.
Conclusions
Although the control group showed significantly higher results, the retention force of polyetheretherketone materials indicate a potential clinical application. Neither the manufacturing process nor artificial aging showed an impact on the retention force of polyetheretherketone clasps.
Clinical relevance
Mechanical properties of novel removable dental prosthesis clasp materials devised to meet the growing esthetic demands of patients need to be investigated to ensure a successful long-term clinical application.</description><subject>Aging</subject><subject>Chromium Alloys</subject><subject>Cobalt</subject><subject>Dental Clasps</subject><subject>Dental Stress Analysis</subject><subject>Dentistry</subject><subject>Denture Retention</subject><subject>Denture, Partial, Removable</subject><subject>Esthetics, Dental</subject><subject>Humans</subject><subject>Ketones</subject><subject>Materials Testing</subject><subject>Mechanical properties</subject><subject>Medicine</subject><subject>Molybdenum</subject><subject>Original</subject><subject>Original Article</subject><subject>Polyethylene Glycols</subject><subject>Prostheses</subject><subject>Prosthetics</subject><subject>Retention</subject><subject>Saliva</subject><subject>Statistical analysis</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UU1v1DAQtRCItgt_gAOyxIWLwR-J41xAqKJQqRIXOFuOPdl1SeJgZyvl3zO7W8rHgcuM9ebNmxk_Ql4I_kZw3rwtGEzFuOSMK80VWx-Rc1EpzVTTiMfHt2S6NeKMXJRyy7modKOekjOluNS1VOdkvS502QHdxe2OzZD7lEc3eTiAeUzz4MoSPZ3TsMIBOobvsKQJaJxC9G6BQF2hjnrkznREIEc3UFSiGcZ057oBaIBpQXDOqaBCgfL-GXnSu6HA8_u8Id-uPn69_Mxuvny6vvxww3xd8YV1QbXBdeBAd33d4v6VUUFwaUznax06z0Pf674FHkBrYVxbKVDeN8rX3hm1Ie9OuvO-GyF4XCS7wc45ji6vNrlo_65McWe36c4arrmUNQq8vhfI6cceymLHWDwMg5sg7YuVVdUKI2ucuyGv_qHepn2e8Dwra4GMqmlaZMkTy-NvlAz9wzKC24Oz9uSsRWft0Vm7YtPLP894aPllJRLUiVCwNG0h_579H9mf9MizwQ</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Micovic, Danka</creator><creator>Mayinger, Felicitas</creator><creator>Bauer, Sebastian</creator><creator>Roos, Malgorzata</creator><creator>Eichberger, Marlis</creator><creator>Stawarczyk, Bogna</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0089-9995</orcidid></search><sort><creationdate>20210501</creationdate><title>Is the high-performance thermoplastic polyetheretherketone indicated as a clasp material for removable dental prostheses?</title><author>Micovic, Danka ; Mayinger, Felicitas ; Bauer, Sebastian ; Roos, Malgorzata ; Eichberger, Marlis ; Stawarczyk, Bogna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-bd39dabeae6bf59673483d10288bc56dbc0dff6f9e0de6618a943e3cc73c5ca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aging</topic><topic>Chromium Alloys</topic><topic>Cobalt</topic><topic>Dental Clasps</topic><topic>Dental Stress Analysis</topic><topic>Dentistry</topic><topic>Denture Retention</topic><topic>Denture, Partial, Removable</topic><topic>Esthetics, Dental</topic><topic>Humans</topic><topic>Ketones</topic><topic>Materials Testing</topic><topic>Mechanical properties</topic><topic>Medicine</topic><topic>Molybdenum</topic><topic>Original</topic><topic>Original Article</topic><topic>Polyethylene Glycols</topic><topic>Prostheses</topic><topic>Prosthetics</topic><topic>Retention</topic><topic>Saliva</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Micovic, Danka</creatorcontrib><creatorcontrib>Mayinger, Felicitas</creatorcontrib><creatorcontrib>Bauer, Sebastian</creatorcontrib><creatorcontrib>Roos, Malgorzata</creatorcontrib><creatorcontrib>Eichberger, Marlis</creatorcontrib><creatorcontrib>Stawarczyk, Bogna</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Micovic, Danka</au><au>Mayinger, Felicitas</au><au>Bauer, Sebastian</au><au>Roos, Malgorzata</au><au>Eichberger, Marlis</au><au>Stawarczyk, Bogna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is the high-performance thermoplastic polyetheretherketone indicated as a clasp material for removable dental prostheses?</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>25</volume><issue>5</issue><spage>2859</spage><epage>2866</epage><pages>2859-2866</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
To investigate the retention force of polyetheretherketone (PEEK) removable dental prosthesis clasps in comparison with a cobalt-chrome-molybdenum control group after storage in artificial saliva.
Materials and Methods
Clasps were milled (Dentokeep (PEEKmilled1), NT digital implant technology; breCAM BioHPP Blank (PEEKmilled2), bredent), pressed (BioHPP Granulat for 2 press (PEEKpressed), bredent), or cast (remanium GM 800+ (cobalt-chrome-molybdenum), Dentaurum);
N
= 60,
n
= 15/subgroup. Retention force was examined 50 times/specimen in a pull-off test using the universal testing machine (Zwick 1445), where pull-off force was applied with a crosshead speed of 5 mm/minute until the maximum force dropped by 10%, at different aging levels: (1) initial, after storage in artificial saliva for (2) 90 and (3) 180 days. Statistical analysis was performed using one-way ANOVA followed by post hoc Scheffé-test and mixed models (
p
< 0.05).
Results
Cobalt-chrome-molybdenum presented the highest retention force. No differences were observed between polyetheretherketone materials. Cobalt-chrome-molybdenum showed a significant decrease of its values after artificial aging, while polyetheretherketone materials presented similar results over the course of aging. Regarding a repetitive insertion and removal, even though PEEKmilled2 and cobalt-chrome-molybdenum showed an initial increase, ultimately, a decrease in retention force was observed for all tested groups.
Conclusions
Although the control group showed significantly higher results, the retention force of polyetheretherketone materials indicate a potential clinical application. Neither the manufacturing process nor artificial aging showed an impact on the retention force of polyetheretherketone clasps.
Clinical relevance
Mechanical properties of novel removable dental prosthesis clasp materials devised to meet the growing esthetic demands of patients need to be investigated to ensure a successful long-term clinical application.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33026523</pmid><doi>10.1007/s00784-020-03603-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0089-9995</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2021-05, Vol.25 (5), p.2859-2866 |
| issn | 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8060225 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aging Chromium Alloys Cobalt Dental Clasps Dental Stress Analysis Dentistry Denture Retention Denture, Partial, Removable Esthetics, Dental Humans Ketones Materials Testing Mechanical properties Medicine Molybdenum Original Original Article Polyethylene Glycols Prostheses Prosthetics Retention Saliva Statistical analysis |
| title | Is the high-performance thermoplastic polyetheretherketone indicated as a clasp material for removable dental prostheses? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T19%3A22%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20the%20high-performance%20thermoplastic%20polyetheretherketone%20indicated%20as%20a%20clasp%20material%20for%20removable%20dental%20prostheses?&rft.jtitle=Clinical%20oral%20investigations&rft.au=Micovic,%20Danka&rft.date=2021-05-01&rft.volume=25&rft.issue=5&rft.spage=2859&rft.epage=2866&rft.pages=2859-2866&rft.issn=1432-6981&rft.eissn=1436-3771&rft_id=info:doi/10.1007/s00784-020-03603-y&rft_dat=%3Cproquest_pubme%3E2515944779%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2515944779&rft_id=info:pmid/33026523&rfr_iscdi=true |