Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance

Adoptive transfer of Tregs has been shown to improve alloengraftment in animal models. However, it is technically challenging to expand Tregs ex vivo for the purpose of infusing large numbers of cells in the clinic. We demonstrate an innovative approach to engineering an orthogonal IL-2/IL-2 recepto...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2021-04, Vol.131 (8), p.1-13, Article 139991
Hauptverfasser:	Hirai, Toshihito, Ramos, Teresa L., Lin, Po-Yu, Simonetta, Federico, Su, Leon L., Picton, Lora K., Baker, Jeanette, Lin, Jian-Xin, Li, Peng, Seo, Kinya, Lohmeyer, Juliane K., Wagers, Sara B., Mavers, Melissa, Leonard, Warren J., Blazar, Bruce R., Garcia, K. Christopher, Negrin, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Allografts Animal models Animals Biomedical research CD4 antigen Cell growth Cell proliferation Cell receptors Cells Chimerism Cytokines Genetic aspects Health aspects Heart transplantation Immunological tolerance Immunoregulation Interleukin 2 Interleukin 2 receptors Interleukin-2 - genetics Interleukin-2 - immunology Life Sciences & Biomedicine Lymphocyte Activation Lymphocytes Lymphocytes T Medical research Medicine, Experimental Medicine, Research & Experimental Mice Mice, Inbred BALB C Mice, Transgenic Receptors, Interleukin-2 - genetics Receptors, Interleukin-2 - immunology Research & Experimental Medicine Science & Technology Signal Transduction - genetics Signal Transduction - immunology T cells T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Transplantation Transplantation Tolerance Transplants & implants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!