Microtopographical patterns promote different responses in fibroblasts and Schwann cells: A possible feature for neural implants

The chronic reliability of bioelectronic neural interfaces has been challenged by foreign body reactions (FBRs) resulting in fibrotic encapsulation and poor integration with neural tissue. Engineered microtopographies could alleviate these challenges by manipulating cellular responses to the implant...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2021-01, Vol.109 (1), p.64-76
Hauptverfasser:	Mobini, Sahba, Kuliasha, Cary A., Siders, Zachary A., Bohmann, Nicole A., Jamal, Syed‐Mustafa, Judy, Jack W., Schmidt, Christine E., Brennan, Anthony B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alignment Animals Axon guidance Axons Bacteria Bacterial Adhesion - drug effects Bioelectricity Cell adhesion Cell Adhesion - drug effects Cell Line Cell morphology Cell proliferation Cell Proliferation - drug effects Computer applications Cytology Cytoskeleton - drug effects Cytoskeleton - ultrastructure Epithelial cells Equipment Design Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - ultrastructure Fibrosis foreign body reaction Implants in vitro In vivo methods and tests Interfaces Mammalian cells Marine organisms microchannel Microchannels microtopography Morphology Nerve Regeneration neural interfaces Neural Prostheses Nuclei (cytology) Parameter identification Pattern formation Patterning Rats Schwann cells Schwann Cells - drug effects Schwann Cells - metabolism Schwann Cells - ultrastructure Sharklet Statistical analysis Surgical implants Variance analysis
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