Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations

Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays and sequenced reference panels that best capture variation most common in European ancestry populations. To compare data generation strategies...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of human genetics 2021-04, Vol.108 (4), p.656-668
Hauptverfasser:	Martin, Alicia R., Atkinson, Elizabeth G., Chapman, Sinéad B., Stevenson, Anne, Stroud, Rocky E., Abebe, Tamrat, Akena, Dickens, Alemayehu, Melkam, Ashaba, Fred K., Atwoli, Lukoye, Bowers, Tera, Chibnik, Lori B., Daly, Mark J., DeSmet, Timothy, Dodge, Sheila, Fekadu, Abebaw, Ferriera, Steven, Gelaye, Bizu, Gichuru, Stella, Injera, Wilfred E., James, Roxanne, Kariuki, Symon M., Kigen, Gabriel, Koenen, Karestan C., Kwobah, Edith, Kyebuzibwa, Joseph, Majara, Lerato, Musinguzi, Henry, Mwema, Rehema M., Neale, Benjamin M., Newman, Carter P., Newton, Charles R.J.C., Pickrell, Joseph K., Ramesar, Raj, Shiferaw, Welelta, Stein, Dan J., Teferra, Solomon, van der Merwe, Celia, Zingela, Zukiswa
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa cost comparison DNA Mutational Analysis - economics DNA Mutational Analysis - methods DNA Mutational Analysis - standards Genetic Variation - genetics Genetics, Population - economics Genetics, Population - methods Genome, Human - genetics Genome-Wide Association Study GWAS GWAS arrays Health Equity Humans low-coverage sequencing Microbiota study design Whole Genome Sequencing - economics Whole Genome Sequencing - standards whole-genome sequencing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!