A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase

Antiviral therapeutics is one effective avenue to control and end this devastating COVID-19 pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been recognized as a valuable target of antivirals. However, the cell-free SARS-CoV-2 RdRp biochemical assay requires the conversion o...

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Veröffentlicht in:	Antiviral research 2021-06, Vol.190, p.105078-105078, Article 105078
Hauptverfasser:	Zhao, Jianyuan, Guo, SaiSai, Yi, Dongrong, Li, Quanjie, Ma, Ling, Zhang, Yongxin, Wang, Jing, Li, Xiaoyu, Guo, Fei, Lin, Rongtuan, Liang, Chen, Liu, Zhenlong, Cen, Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - pharmacology Alanine - analogs & derivatives Alanine - pharmacology Antiviral Antiviral Agents - pharmacology Cell Survival - drug effects COVID-19 COVID-19 - virology COVID-19 Drug Treatment Drug Discovery Exoribonucleases - antagonists & inhibitors HEK293 Cells High-throughput High-Throughput Screening Assays Humans Nucleotide analog inhibitor RdRp Remdesivir Research Paper RNA, Viral - genetics RNA-Dependent RNA Polymerase - antagonists & inhibitors SARS-CoV-2 SARS-CoV-2 - drug effects SARS-CoV-2 - enzymology SARS-CoV-2 - genetics Viral Nonstructural Proteins - antagonists & inhibitors
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