Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk

BACKGROUNDKCNMA1 encodes the α-subunit of the large-conductance Ca2+-activated K+ channel, KCa1.1, and lies within a linkage interval for atrial fibrillation (AF). Insights into the cardiac functions of KCa1.1 are limited, and KCNMA1 has not been investigated as an AF candidate gene. METHODSThe KCNM...

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Veröffentlicht in:	Circulation. Genomic and precision medicine 2021-04, Vol.14 (2), p.e003144-e003144
Hauptverfasser:	Pineda, Santiago, Nikolova-Krstevski, Vesna, Leimena, Christiana, Atkinson, Andrew J., Altekoester, Ann-Kristin, Cox, Charles D., Jacoby, Arie, Huttner, Inken G., Ju, Yue-Kun, Soka, Magdalena, Ohanian, Monique, Trivedi, Gunjan, Kalvakuri, Sreehari, Birker, Katja, Johnson, Renee, Molenaar, Peter, Kuchar, Dennis, Allen, David G., van Helden, Dirk F., Harvey, Richard P., Hill, Adam P., Bodmer, Rolf, Vogler, Georg, Dobrzynski, Halina, Ocorr, Karen, Fatkin, Diane
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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