Involvement of the γ-Secretase-Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease

Loss of synapses is associated with cognitive impairment in Alzheimer's disease (AD). However, the molecular mechanism underlying this synaptic impairment is not well understood. EphA4 is a substrate of γ‐secretase, and the γ‐secretase‐cleaved EphA4 intracellular domain (EICD) is known to enhan...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2012-11, Vol.22 (6), p.776-787
Hauptverfasser:	Matsui, Chiyuki, Inoue, Eiji, Kakita, Akiyoshi, Arita, Kohei, Deguchi-Tawarada, Maki, Togawa, Aki, Yamada, Akio, Takai, Yoshimi, Takahashi, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Precursor Protein Secretases - metabolism Animals Blotting, Western Brain - metabolism Brain - pathology dendritic spine EphA4 Humans Indexing in process Rac Rats Receptor, EphA4 - metabolism Signal Transduction - physiology Synapses - metabolism Synapses - pathology γ-secretase
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