Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely characterized. We report that fatty acid synthase knockdown (FASNKD) in ECs impedes vessel sprouting by reducing proliferation. Endothelial loss of FASN impaired angiogenesis in vivo, while FASN blockade reduced patholo...

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Veröffentlicht in:	Cell metabolism 2018-12, Vol.28 (6), p.866-880.e15
Hauptverfasser:	Bruning, Ulrike, Morales-Rodriguez, Francisco, Kalucka, Joanna, Goveia, Jermaine, Taverna, Federico, Queiroz, Karla C.S., Dubois, Charlotte, Cantelmo, Anna Rita, Chen, Rongyuan, Loroch, Stefan, Timmerman, Evy, Caixeta, Vanessa, Bloch, Katarzyna, Conradi, Lena-Christin, Treps, Lucas, Staes, An, Gevaert, Kris, Tee, Andrew, Dewerchin, Mieke, Semenkovich, Clay F., Impens, Francis, Schilling, Birgit, Verdin, Eric, Swinnen, Johannes V., Meier, Jordan L., Kulkarni, Rhushikesh A., Sickmann, Albert, Ghesquière, Bart, Schoonjans, Luc, Li, Xuri, Mazzone, Massimiliano, Carmeliet, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - antagonists & inhibitors angiogenesis Animals Cell Line, Tumor Cell Proliferation endothelial cell fatty acid synthase Fatty Acid Synthase, Type I - antagonists & inhibitors Fatty Acid Synthase, Type I - genetics Fatty Acid Synthase, Type I - physiology Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans lipids Malonyl Coenzyme A - metabolism malonyl-CoA Mechanistic Target of Rapamycin Complex 1 - metabolism metabolism Mice Mice, Inbred C57BL Mice, Knockout mTOR mTORC1 Orlistat - therapeutic use post-translational modifications protein malonylation Protein Processing, Post-Translational Retinal Neovascularization - drug therapy Retinal Neovascularization - pathology TOR Serine-Threonine Kinases - metabolism
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