Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project
Telomere length (TL) has been linked to several psychiatric conditions in children and adults. Telomere shortening is accelerated by early adversity, including maltreatment and psychosocial deprivation. These experiences also increase the risk of psychopathology in many domains. Two fundamental issu...
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description | Telomere length (TL) has been linked to several psychiatric conditions in children and adults. Telomere shortening is accelerated by early adversity, including maltreatment and psychosocial deprivation. These experiences also increase the risk of psychopathology in many domains. Two fundamental issues remain unresolved. The first concerns the specificity of the relations between TL and different dimensions of psychopathology; and the second relates to the direction of association between TL and psychopathology.
This study addressed these shortcomings in a 2-fold manner. First, the association between TL and statistically independent general, internalizing, and externalizing psychopathology factors was examined to determine the specificity of this relation. Second, a 2-wave longitudinal cross-lagged model was used to explicitly examine the direction of the relation between TL and each psychopathology factor. Data were drawn from the Bucharest Early Intervention Project, a longitudinal study exploring the impact of severe psychosocial deprivation on child health and development (N = 195). At 8 to 10 and 12 to 14 years of age, buccal DNA was collected and teachers and/or caregivers reported on different domains of psychopathology.
Longitudinal path analyses showed that shorter TL was specifically associated with higher internalizing psychopathology at 8 to 10 years of age. In contrast, at 12 to 14 years, shorter TL was associated with higher general psychopathology. Most telling, internalizing psychopathology at 8 to 10 years predicted shorter TL at 12 to 14 years, with no reciprocal effects.
Results suggest that telomere erosion could be a consequence of distress-related psychopathology rather than a selection mechanism for later psychiatric problems.
The Bucharest Early Intervention Project; https://clinicaltrials.gov/; NCT00747396. |
doi_str_mv | 10.1016/j.jaac.2019.02.013 |
format | Article |
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This study addressed these shortcomings in a 2-fold manner. First, the association between TL and statistically independent general, internalizing, and externalizing psychopathology factors was examined to determine the specificity of this relation. Second, a 2-wave longitudinal cross-lagged model was used to explicitly examine the direction of the relation between TL and each psychopathology factor. Data were drawn from the Bucharest Early Intervention Project, a longitudinal study exploring the impact of severe psychosocial deprivation on child health and development (N = 195). At 8 to 10 and 12 to 14 years of age, buccal DNA was collected and teachers and/or caregivers reported on different domains of psychopathology.
Longitudinal path analyses showed that shorter TL was specifically associated with higher internalizing psychopathology at 8 to 10 years of age. In contrast, at 12 to 14 years, shorter TL was associated with higher general psychopathology. Most telling, internalizing psychopathology at 8 to 10 years predicted shorter TL at 12 to 14 years, with no reciprocal effects.
Results suggest that telomere erosion could be a consequence of distress-related psychopathology rather than a selection mechanism for later psychiatric problems.
The Bucharest Early Intervention Project; https://clinicaltrials.gov/; NCT00747396.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1016/j.jaac.2019.02.013</identifier><identifier>PMID: 30844465</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adversity ; Caregivers ; Child ; Child & adolescent psychiatry ; Child abuse & neglect ; Child development ; Child Health ; Children ; Deoxyribonucleic acid ; Deprivation ; DNA ; early adversity ; Early intervention ; externalizing problems ; Female ; general psychopathology ; Humans ; Internalization ; internalizing problems ; Longitudinal Studies ; Male ; Mental disorders ; Psychiatry ; Psychological distress ; Psychopathology ; Psychosocial Deprivation ; Psychosocial factors ; Teachers ; Telomere - metabolism ; telomere length ; Telomere Shortening</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 2020-01, Vol.59 (1), p.140-148.e3</ispartof><rights>2019 American Academy of Child and Adolescent Psychiatry</rights><rights>Copyright © 2019 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Lippincott Williams & Wilkins Ovid Technologies Jan 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-48c726fd652ca5617c7820c7e82bc1fb276205d5240cd2b95341aa9e2e499c663</citedby><cites>FETCH-LOGICAL-c483t-48c726fd652ca5617c7820c7e82bc1fb276205d5240cd2b95341aa9e2e499c663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaac.2019.02.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,30980,33755,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30844465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wade, Mark</creatorcontrib><creatorcontrib>Fox, Nathan A.</creatorcontrib><creatorcontrib>Zeanah, Charles H.</creatorcontrib><creatorcontrib>Nelson, Charles A.</creatorcontrib><creatorcontrib>Drury, Stacy S.</creatorcontrib><title>Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><description>Telomere length (TL) has been linked to several psychiatric conditions in children and adults. Telomere shortening is accelerated by early adversity, including maltreatment and psychosocial deprivation. These experiences also increase the risk of psychopathology in many domains. Two fundamental issues remain unresolved. The first concerns the specificity of the relations between TL and different dimensions of psychopathology; and the second relates to the direction of association between TL and psychopathology.
This study addressed these shortcomings in a 2-fold manner. First, the association between TL and statistically independent general, internalizing, and externalizing psychopathology factors was examined to determine the specificity of this relation. Second, a 2-wave longitudinal cross-lagged model was used to explicitly examine the direction of the relation between TL and each psychopathology factor. Data were drawn from the Bucharest Early Intervention Project, a longitudinal study exploring the impact of severe psychosocial deprivation on child health and development (N = 195). At 8 to 10 and 12 to 14 years of age, buccal DNA was collected and teachers and/or caregivers reported on different domains of psychopathology.
Longitudinal path analyses showed that shorter TL was specifically associated with higher internalizing psychopathology at 8 to 10 years of age. In contrast, at 12 to 14 years, shorter TL was associated with higher general psychopathology. Most telling, internalizing psychopathology at 8 to 10 years predicted shorter TL at 12 to 14 years, with no reciprocal effects.
Results suggest that telomere erosion could be a consequence of distress-related psychopathology rather than a selection mechanism for later psychiatric problems.
The Bucharest Early Intervention Project; https://clinicaltrials.gov/; NCT00747396.</description><subject>Adolescent</subject><subject>Adversity</subject><subject>Caregivers</subject><subject>Child</subject><subject>Child & adolescent psychiatry</subject><subject>Child abuse & neglect</subject><subject>Child development</subject><subject>Child Health</subject><subject>Children</subject><subject>Deoxyribonucleic acid</subject><subject>Deprivation</subject><subject>DNA</subject><subject>early adversity</subject><subject>Early intervention</subject><subject>externalizing problems</subject><subject>Female</subject><subject>general psychopathology</subject><subject>Humans</subject><subject>Internalization</subject><subject>internalizing problems</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Psychiatry</subject><subject>Psychological distress</subject><subject>Psychopathology</subject><subject>Psychosocial Deprivation</subject><subject>Psychosocial factors</subject><subject>Teachers</subject><subject>Telomere - metabolism</subject><subject>telomere length</subject><subject>Telomere Shortening</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>BHHNA</sourceid><recordid>eNp9kUGL1DAcxYMo7rj6BTxIwIuXjkmapKmIoOuoCwMuuOIxZNJ_pymdZEzagX57MzProh48hZDfe7yXh9BzSpaUUPm6X_bG2CUjtF4StiS0fIAWVLCqEJyqh2hBVE0KJWR1gZ6k1BNCaKXUY3RREsU5l2KB5lsYwg4i4DX47dhh4xt8k2bbhb0ZuzCE7fwGf9uDda2zbpxPwEcXwY4ueBxavGrbfEn4hxs75_HYAf4w2c5ESCNemTjM-NqPEA_gT5KbGPoseIoetWZI8OzuvETfP61ur74U66-fr6_erwvLVTkWXNmKybaRglkjJK1spRixFSi2sbTdsEoyIhrBOLEN29Si5NSYGhjwurZSlpfo3dl3P2120NicIppB76PbmTjrYJz--8W7Tm_DQSsipFIiG7y6M4jh55RL6Z1LFobBeAhT0oyqWnBZyzKjL_9B-zBFn-tpVpaMVFLxYyJ2pmwMKUVo78NQoo_L6l4fl9XHZTVhOi-bRS_-rHEv-T1lBt6eAcifeXAQdbIOvIXmNJZugvuf_y_nhbZQ</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Wade, Mark</creator><creator>Fox, Nathan A.</creator><creator>Zeanah, Charles H.</creator><creator>Nelson, Charles A.</creator><creator>Drury, Stacy S.</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7U3</scope><scope>BHHNA</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project</title><author>Wade, Mark ; Fox, Nathan A. ; Zeanah, Charles H. ; Nelson, Charles A. ; Drury, Stacy S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-48c726fd652ca5617c7820c7e82bc1fb276205d5240cd2b95341aa9e2e499c663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adversity</topic><topic>Caregivers</topic><topic>Child</topic><topic>Child & adolescent psychiatry</topic><topic>Child abuse & neglect</topic><topic>Child development</topic><topic>Child Health</topic><topic>Children</topic><topic>Deoxyribonucleic acid</topic><topic>Deprivation</topic><topic>DNA</topic><topic>early adversity</topic><topic>Early intervention</topic><topic>externalizing problems</topic><topic>Female</topic><topic>general psychopathology</topic><topic>Humans</topic><topic>Internalization</topic><topic>internalizing problems</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Psychiatry</topic><topic>Psychological distress</topic><topic>Psychopathology</topic><topic>Psychosocial Deprivation</topic><topic>Psychosocial factors</topic><topic>Teachers</topic><topic>Telomere - metabolism</topic><topic>telomere length</topic><topic>Telomere Shortening</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wade, Mark</creatorcontrib><creatorcontrib>Fox, Nathan A.</creatorcontrib><creatorcontrib>Zeanah, Charles H.</creatorcontrib><creatorcontrib>Nelson, Charles A.</creatorcontrib><creatorcontrib>Drury, Stacy S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wade, Mark</au><au>Fox, Nathan A.</au><au>Zeanah, Charles H.</au><au>Nelson, Charles A.</au><au>Drury, Stacy S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project</atitle><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>59</volume><issue>1</issue><spage>140</spage><epage>148.e3</epage><pages>140-148.e3</pages><issn>0890-8567</issn><eissn>1527-5418</eissn><abstract>Telomere length (TL) has been linked to several psychiatric conditions in children and adults. Telomere shortening is accelerated by early adversity, including maltreatment and psychosocial deprivation. These experiences also increase the risk of psychopathology in many domains. Two fundamental issues remain unresolved. The first concerns the specificity of the relations between TL and different dimensions of psychopathology; and the second relates to the direction of association between TL and psychopathology.
This study addressed these shortcomings in a 2-fold manner. First, the association between TL and statistically independent general, internalizing, and externalizing psychopathology factors was examined to determine the specificity of this relation. Second, a 2-wave longitudinal cross-lagged model was used to explicitly examine the direction of the relation between TL and each psychopathology factor. Data were drawn from the Bucharest Early Intervention Project, a longitudinal study exploring the impact of severe psychosocial deprivation on child health and development (N = 195). At 8 to 10 and 12 to 14 years of age, buccal DNA was collected and teachers and/or caregivers reported on different domains of psychopathology.
Longitudinal path analyses showed that shorter TL was specifically associated with higher internalizing psychopathology at 8 to 10 years of age. In contrast, at 12 to 14 years, shorter TL was associated with higher general psychopathology. Most telling, internalizing psychopathology at 8 to 10 years predicted shorter TL at 12 to 14 years, with no reciprocal effects.
Results suggest that telomere erosion could be a consequence of distress-related psychopathology rather than a selection mechanism for later psychiatric problems.
The Bucharest Early Intervention Project; https://clinicaltrials.gov/; NCT00747396.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30844465</pmid><doi>10.1016/j.jaac.2019.02.013</doi><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adversity Caregivers Child Child & adolescent psychiatry Child abuse & neglect Child development Child Health Children Deoxyribonucleic acid Deprivation DNA early adversity Early intervention externalizing problems Female general psychopathology Humans Internalization internalizing problems Longitudinal Studies Male Mental disorders Psychiatry Psychological distress Psychopathology Psychosocial Deprivation Psychosocial factors Teachers Telomere - metabolism telomere length Telomere Shortening |
title | Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project |
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