Inhibition of transforming growth factor-beta by Tranilast reduces tumor growth and ameliorates fibrosis in colorectal cancer

Transforming Growth Factor-beta (TGF-β) is dysregulated in colorectal cancer and there is growing evidence that it is associated with a poor prognosis and chemo-resistance in several malignances, including CRC. In this study we have explored the therapeutic potential of targeting TGF-β using Tranila...

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Veröffentlicht in:	EXCLI journal 2021-01, Vol.20, p.601-613
Hauptverfasser:	Hashemzehi, Milad, Yavari, Negar, Rahmani, Farzad, Asgharzadeh, Fereshteh, Soleimani, Atena, Shakour, Neda, Avan, Amir, Hadizadeh, Farzin, Fakhraie, Maryam, Marjaneh, Reyhaneh Moradi, Ferns, Gordon A, Reisi, Parham, Ryzhikov, Mikhail, Khazaei, Majid, Hassanian, Seyed Mahdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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