Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside
Cancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tum...
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| Veröffentlicht in: | Clinical research in cardiology 2021-04, Vol.110 (4), p.507-531 |
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| creator | Sárközy, Márta Varga, Zoltán Gáspár, Renáta Szűcs, Gergő Kovács, Mónika G. Kovács, Zsuzsanna Z. A. Dux, László Kahán, Zsuzsanna Csont, Tamás |
| description | Cancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tumor cells; however, it may have deleterious side effects on the surrounding normal tissues. The syndrome of unwanted cardiovascular adverse effects of thoracic RT is termed radiation-induced heart disease (RIHD), and the risk of developing RIHD is a critical concern in current oncology practice. Premature ischemic heart disease, cardiomyopathy, heart failure, valve abnormalities, and electrical conduct defects are common forms of RIHD. The underlying mechanisms of RIHD are still not entirely clear, and specific therapeutic interventions are missing. In this review, we focus on the molecular pathomechanisms of acute and chronic RIHD and propose preventive measures and possible pharmacological strategies to minimize the burden of RIHD. |
| doi_str_mv | 10.1007/s00392-021-01809-y |
| format | Article |
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Premature ischemic heart disease, cardiomyopathy, heart failure, valve abnormalities, and electrical conduct defects are common forms of RIHD. The underlying mechanisms of RIHD are still not entirely clear, and specific therapeutic interventions are missing. 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| subjects | Abnormalities Breast cancer Cancer Cardiology Cardiomyopathy Cardiovascular disease Cardiovascular diseases Congestive heart failure Coronary artery disease Disease prevention Esophageal cancer Esophagus Health risks Heart Heart diseases Hodgkin's lymphoma Ischemia Lung cancer Lymphoma Medicine Medicine & Public Health Radiation Radiation effects Radiation therapy Review Rheumatic heart disease Side effects Survival Therapeutic applications Thorax Tumor cells Tumors |
| title | Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside |
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