A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization

The central pathogen-immune interface in tuberculosis is the granuloma, a complex host immune structure that dictates infection trajectory and physiology. Granuloma macrophages undergo a dramatic transition in which entire epithelial modules are induced and define granuloma architecture. In tubercul...

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Veröffentlicht in:	Cell 2021-04, Vol.184 (7), p.1757-1774.e14
Hauptverfasser:	Cronan, Mark R., Hughes, Erika J., Brewer, W. Jared, Viswanathan, Gopinath, Hunt, Emily G., Singh, Bindu, Mehra, Smriti, Oehlers, Stefan H., Gregory, Simon G., Kaushal, Deepak, Tobin, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - metabolism Cadherins - genetics Cadherins - metabolism Cell Differentiation Disease Models, Animal epithelialization Epithelioid Cells - cytology Epithelioid Cells - immunology Epithelioid Cells - metabolism granuloma Granuloma - immunology Granuloma - metabolism Granuloma - pathology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism IL4R Immunity - physiology Interferon-gamma - metabolism Interleukin-12 - metabolism macrophage Macrophages - cytology Macrophages - immunology Macrophages - metabolism Mycobacterium Mycobacterium Infections, Nontuberculous - immunology Mycobacterium Infections, Nontuberculous - pathology Mycobacterium marinum - isolation & purification Mycobacterium marinum - physiology Necrosis Receptors, Interleukin-4 - antagonists & inhibitors Receptors, Interleukin-4 - genetics Receptors, Interleukin-4 - metabolism RNA, Guide, CRISPR-Cas Systems Signal Transduction STAT6 STAT6 Transcription Factor - antagonists & inhibitors STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism tuberculosis zebrafish Zebrafish - growth & development Zebrafish - metabolism
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