Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (NAMPTi) are currently in development, but may be limited as single-agent therapy due to compound-specific toxicity and cancer metabolic plasticity allowing resistance development. To potentially lower the doses of NAMPTis required for therap...

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Veröffentlicht in:	Clinical cancer research 2021-04, Vol.27 (8), p.2352-2366
Hauptverfasser:	Zhang, Pu, Brinton, Lindsey T, Williams, Katie, Sher, Steven, Orwick, Shelley, Tzung-Huei, Lai, Mims, Alice S, Coss, Christopher C, Kulp, Samuel K, Youssef, Youssef, Chan, Wing Keung, Mitchell, Shaneice, Mustonen, Allison, Cannon, Matthew, Phillips, Hannah, Lehman, Amy M, Kauffman, Tierney, Beaver, Larry, Canfield, Daniel, Grieselhuber, Nicole R, Alinari, Lapo, Sampath, Deepa, Yan, Pearlly, Byrd, John C, Blachly, James S, Lapalombella, Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - pharmacology Acrylamides - therapeutic use Aminopyridines - pharmacology Aminopyridines - therapeutic use Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cell Line, Tumor Cytokines - antagonists & inhibitors DNA Damage DNA End-Joining Repair - drug effects Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Knockout Techniques Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Indoles - pharmacology Indoles - therapeutic use Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Male Mice Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors Phenylbutyrates - pharmacology Phenylbutyrates - therapeutic use Recombinational DNA Repair - drug effects Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics Repressor Proteins - metabolism Sirtuins - antagonists & inhibitors Sirtuins - genetics Sirtuins - metabolism Xenograft Model Antitumor Assays
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