Candia albicans lumbar spondylodiscitis contiguous to infected abdominal aortic aneurysm in an intravenous drug user
While the incidence of spondylodiscitis is rising because of longer life expectancy and the increasing use of immunosuppressant drug, indwelling devices and spinal surgeries, the fungal aetiology remains rare, sometimes affecting intravenous drug users. Candida spondylodiscitis is an extremely rare...
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description | While the incidence of spondylodiscitis is rising because of longer life expectancy and the increasing use of immunosuppressant drug, indwelling devices and spinal surgeries, the fungal aetiology remains rare, sometimes affecting intravenous drug users. Candida spondylodiscitis is an extremely rare complication post aortic aneurysm repair. It is potentially fatal due to the risk of aneurysm rupture and septic complications. The growing problem of systemic diseases caused by Candida species reflects the enormous increase of patients at risk. The treatment of this complicated entity is challenging and often requiring a multidisciplinary team. We reported the rare case of Candida spondylodiscitis contiguous to infected aortic aneurysm in a 74-year-old male intravenous drug user, to the extent which the vertebral body bony destruction progressed to need one-stage posterior and anterior spinal fusion surgery with curettage. Our surgical intervention combined with prolonged course of antifungal therapy could successfully eradicate the infection and resolve the neurological deficits. |
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Candida spondylodiscitis is an extremely rare complication post aortic aneurysm repair. It is potentially fatal due to the risk of aneurysm rupture and septic complications. The growing problem of systemic diseases caused by Candida species reflects the enormous increase of patients at risk. The treatment of this complicated entity is challenging and often requiring a multidisciplinary team. We reported the rare case of Candida spondylodiscitis contiguous to infected aortic aneurysm in a 74-year-old male intravenous drug user, to the extent which the vertebral body bony destruction progressed to need one-stage posterior and anterior spinal fusion surgery with curettage. Our surgical intervention combined with prolonged course of antifungal therapy could successfully eradicate the infection and resolve the neurological deficits.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2020-241493</identifier><identifier>PMID: 33853820</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Abdomen ; Abscesses ; Aged ; Aneurysm, Infected - diagnostic imaging ; Aneurysm, Infected - drug therapy ; Aneurysm, Infected - surgery ; Aneurysms ; Antibiotics ; Antifungal agents ; Aortic Aneurysm, Abdominal - complications ; Aortic Aneurysm, Abdominal - diagnostic imaging ; Aortic Aneurysm, Abdominal - surgery ; Aortic aneurysms ; Back pain ; Biopsy ; Blood ; Case Report ; Case reports ; Coronary vessels ; Diabetes ; Discitis - drug therapy ; Disease ; Drug abuse ; Drug Users ; Histopathology ; Humans ; Infections ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - surgery ; Male ; Malnutrition ; Neurosurgery ; Patients ; Skin & tissue grafts ; Soil erosion ; Stents ; Substance abuse treatment ; Substance Abuse, Intravenous - complications ; Surgery</subject><ispartof>BMJ case reports, 2021-04, Vol.14 (4), p.e241493</ispartof><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b456t-42b93ad23b1bcc8d106ce81ffc818f1a44b7f4c392af33168a12fb40f4f9b9f33</citedby><cites>FETCH-LOGICAL-b456t-42b93ad23b1bcc8d106ce81ffc818f1a44b7f4c392af33168a12fb40f4f9b9f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054092/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054092/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33853820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Tsuyoshi</creatorcontrib><creatorcontrib>Shindo, Shigeo</creatorcontrib><creatorcontrib>Otani, Kazuyuki</creatorcontrib><creatorcontrib>Nakai, Osamu</creatorcontrib><title>Candia albicans lumbar spondylodiscitis contiguous to infected abdominal aortic aneurysm in an intravenous drug user</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>While the incidence of spondylodiscitis is rising because of longer life expectancy and the increasing use of immunosuppressant drug, indwelling devices and spinal surgeries, the fungal aetiology remains rare, sometimes affecting intravenous drug users. Candida spondylodiscitis is an extremely rare complication post aortic aneurysm repair. It is potentially fatal due to the risk of aneurysm rupture and septic complications. The growing problem of systemic diseases caused by Candida species reflects the enormous increase of patients at risk. The treatment of this complicated entity is challenging and often requiring a multidisciplinary team. We reported the rare case of Candida spondylodiscitis contiguous to infected aortic aneurysm in a 74-year-old male intravenous drug user, to the extent which the vertebral body bony destruction progressed to need one-stage posterior and anterior spinal fusion surgery with curettage. Our surgical intervention combined with prolonged course of antifungal therapy could successfully eradicate the infection and resolve the neurological deficits.</description><subject>Abdomen</subject><subject>Abscesses</subject><subject>Aged</subject><subject>Aneurysm, Infected - diagnostic imaging</subject><subject>Aneurysm, Infected - drug therapy</subject><subject>Aneurysm, Infected - surgery</subject><subject>Aneurysms</subject><subject>Antibiotics</subject><subject>Antifungal agents</subject><subject>Aortic Aneurysm, Abdominal - complications</subject><subject>Aortic Aneurysm, Abdominal - diagnostic imaging</subject><subject>Aortic Aneurysm, Abdominal - surgery</subject><subject>Aortic aneurysms</subject><subject>Back pain</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Discitis - drug therapy</subject><subject>Disease</subject><subject>Drug abuse</subject><subject>Drug Users</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Infections</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Neurosurgery</subject><subject>Patients</subject><subject>Skin & tissue grafts</subject><subject>Soil erosion</subject><subject>Stents</subject><subject>Substance abuse treatment</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>Surgery</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkcuLFDEQxoMo7rLu2ZsEvAnt5tU96Ysgw_qABS8K3kLlNWboTsY8Fua_N8Osy3oyh6RI_eqrKj6EXlPynlI-3WiTB0YYGZigYubP0CXdjJthM5Ofz5_EF-i6lD3ph1MhBX-JLjiXI5eMXKK6hWgDYFh0MBALXtqqIeNySNEel2RDMaGGgk2KNexaagXXhEP0zlRnMWib1hBhwZByDQZDdC0fy9qRHve7Zrh38VRnc9vhVlx-hV54WIq7fniv0I9Pt9-3X4a7b5-_bj_eDVqMUx0E0zMHy7im2hhpKZmMk9R7I6n0FITQGy8Mnxl4zukkgTKvBfHCz3ruX1fow1n30PTqrHGnYRZ1yGGFfFQJgvo3E8MvtUv3SpJRkJl1gbcPAjn9bq5UtU8t922LYiNlExMznTp1c6ZMTqVk5x87UKJOTqnulDo5pc5O9Yo3Twd75P_60oF3Z0Cv-_-q_QFWOKAY</recordid><startdate>20210414</startdate><enddate>20210414</enddate><creator>Yamada, Tsuyoshi</creator><creator>Shindo, Shigeo</creator><creator>Otani, Kazuyuki</creator><creator>Nakai, Osamu</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20210414</creationdate><title>Candia albicans lumbar spondylodiscitis contiguous to infected abdominal aortic aneurysm in an intravenous drug user</title><author>Yamada, Tsuyoshi ; Shindo, Shigeo ; Otani, Kazuyuki ; Nakai, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b456t-42b93ad23b1bcc8d106ce81ffc818f1a44b7f4c392af33168a12fb40f4f9b9f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdomen</topic><topic>Abscesses</topic><topic>Aged</topic><topic>Aneurysm, Infected - diagnostic imaging</topic><topic>Aneurysm, Infected - drug therapy</topic><topic>Aneurysm, Infected - surgery</topic><topic>Aneurysms</topic><topic>Antibiotics</topic><topic>Antifungal agents</topic><topic>Aortic Aneurysm, Abdominal - complications</topic><topic>Aortic Aneurysm, Abdominal - diagnostic imaging</topic><topic>Aortic Aneurysm, Abdominal - surgery</topic><topic>Aortic aneurysms</topic><topic>Back pain</topic><topic>Biopsy</topic><topic>Blood</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Discitis - drug therapy</topic><topic>Disease</topic><topic>Drug abuse</topic><topic>Drug Users</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Infections</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Neurosurgery</topic><topic>Patients</topic><topic>Skin & tissue grafts</topic><topic>Soil erosion</topic><topic>Stents</topic><topic>Substance abuse treatment</topic><topic>Substance Abuse, Intravenous - complications</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Tsuyoshi</creatorcontrib><creatorcontrib>Shindo, Shigeo</creatorcontrib><creatorcontrib>Otani, Kazuyuki</creatorcontrib><creatorcontrib>Nakai, Osamu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Tsuyoshi</au><au>Shindo, Shigeo</au><au>Otani, Kazuyuki</au><au>Nakai, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candia albicans lumbar spondylodiscitis contiguous to infected abdominal aortic aneurysm in an intravenous drug user</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2021-04-14</date><risdate>2021</risdate><volume>14</volume><issue>4</issue><spage>e241493</spage><pages>e241493-</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>While the incidence of spondylodiscitis is rising because of longer life expectancy and the increasing use of immunosuppressant drug, indwelling devices and spinal surgeries, the fungal aetiology remains rare, sometimes affecting intravenous drug users. Candida spondylodiscitis is an extremely rare complication post aortic aneurysm repair. It is potentially fatal due to the risk of aneurysm rupture and septic complications. The growing problem of systemic diseases caused by Candida species reflects the enormous increase of patients at risk. The treatment of this complicated entity is challenging and often requiring a multidisciplinary team. We reported the rare case of Candida spondylodiscitis contiguous to infected aortic aneurysm in a 74-year-old male intravenous drug user, to the extent which the vertebral body bony destruction progressed to need one-stage posterior and anterior spinal fusion surgery with curettage. Our surgical intervention combined with prolonged course of antifungal therapy could successfully eradicate the infection and resolve the neurological deficits.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>33853820</pmid><doi>10.1136/bcr-2020-241493</doi><oa>free_for_read</oa></addata></record> |
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subjects | Abdomen Abscesses Aged Aneurysm, Infected - diagnostic imaging Aneurysm, Infected - drug therapy Aneurysm, Infected - surgery Aneurysms Antibiotics Antifungal agents Aortic Aneurysm, Abdominal - complications Aortic Aneurysm, Abdominal - diagnostic imaging Aortic Aneurysm, Abdominal - surgery Aortic aneurysms Back pain Biopsy Blood Case Report Case reports Coronary vessels Diabetes Discitis - drug therapy Disease Drug abuse Drug Users Histopathology Humans Infections Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - surgery Male Malnutrition Neurosurgery Patients Skin & tissue grafts Soil erosion Stents Substance abuse treatment Substance Abuse, Intravenous - complications Surgery |
title | Candia albicans lumbar spondylodiscitis contiguous to infected abdominal aortic aneurysm in an intravenous drug user |
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