Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes: An in silico perspective

The high morbidity and mortality rate of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection arises majorly from the Acute Respiratory Distress Syndrome and “cytokine storm” syndrome, which is sustained by an aberrant systemic inflammatory response and elevated pro-inflammatory cy...

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Veröffentlicht in:	Computers in biology and medicine 2021-07, Vol.134, p.104406-104406, Article 104406
Hauptverfasser:	Gyebi, Gideon A., Ogunyemi, Oludare M., Ibrahim, Ibrahim M., Afolabi, Saheed O., Adebayo, Joseph O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory activity Anti-inflammatory agents Antiviral activity Antiviral drugs Binding energy Binding sites Chymotrypsin Coronaviruses COVID-19 Cytokine storm Cytokines Dexamethasone Disease DNA-directed RNA polymerase Drug development Dynamic stability Dynamic structural analysis Glucocorticoid receptors Glucocorticoids Granulocytes In vivo methods and tests Infections Inflammation Inflammatory response Interleukins Kinases Ligands Molecular docking Molecular dynamics Morbidity Papain Plants Pregnanes Protease Proteinase Proteins Respiration Respiratory diseases Respiratory distress syndrome RNA polymerase RNA-directed RNA polymerase Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Stability analysis Structural stability Target recognition Tumor necrosis factor-TNF Viral diseases Viral infections
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