Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A

The translation inhibitor rocaglamide A (RocA) has shown promising antitumor activity because it uniquely clamps eukaryotic initiation factor (eIF) 4A onto polypurine RNA for selective translational repression. As eIF4A has been speculated to be a unique target of RocA, alternative targets have not...

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Veröffentlicht in:	Cell chemical biology 2021-04, Vol.28 (4), p.475-486.e8
Hauptverfasser:	Chen, Mingming, Asanuma, Miwako, Takahashi, Mari, Shichino, Yuichi, Mito, Mari, Fujiwara, Koichi, Saito, Hironori, Floor, Stephen N., Ingolia, Nicholas T., Sodeoka, Mikiko, Dodo, Kosuke, Ito, Takuhiro, Iwasaki, Shintaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzofurans - chemistry Benzofurans - pharmacology Cells, Cultured DDX3 DEAD-box RNA Helicases - antagonists & inhibitors DEAD-box RNA Helicases - metabolism dominant negative eIF4A Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Eukaryotic Initiation Factor-4A - antagonists & inhibitors Eukaryotic Initiation Factor-4A - metabolism Female Humans Male Models, Molecular Molecular Conformation ribosome ribosome profiling RNA RNA Bind-n-Seq rocaglate translation translation inhibitor
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