Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus complicated with hypothyroidism
To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus (T2DM) complicated with hypothyroidism.Fifty-five patients with type-2 diabetes who were admitted to our hospital from August 2018 to February 2020 were selected as the control group, and 55 patient...
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| description | To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus (T2DM) complicated with hypothyroidism.Fifty-five patients with type-2 diabetes who were admitted to our hospital from August 2018 to February 2020 were selected as the control group, and 55 patients with type 2 diabetes combined with hypothyroidism who were admitted to the hospital at the same period were selected as the combined group, and 56 patients who came to our hospital for physical examination at the same period were selected as the healthy group. The general clinical data and relevant laboratory indexes of all patients in the three groups were collected and statistically analyzed. Besides, the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and T2DM complicated with hypothyroidism was analyzed.Levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, TgAb, and HOMA-IR in the diabetes group and combined group were all significantly higher than those in the healthy group, while HDL and T4 levels in the diabetes group and combined group were lower than those in the healthy group (P |
| doi_str_mv | 10.1097/MD.0000000000025432 |
| format | Article |
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The general clinical data and relevant laboratory indexes of all patients in the three groups were collected and statistically analyzed. Besides, the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and T2DM complicated with hypothyroidism was analyzed.Levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, TgAb, and HOMA-IR in the diabetes group and combined group were all significantly higher than those in the healthy group, while HDL and T4 levels in the diabetes group and combined group were lower than those in the healthy group (P < .05). The levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, and TgAb in the combined group were significantly higher than those in the diabetes group (P < .05), and the levels of HDL and T4 were lower than those in the diabetes group. In addition, the IGF-1 level was positively correlated with ZAG, nesfatin-1, and HbA1c levels in the combined group (P < .05), and IGF-1 (OR: 0.964, 95% CI: 0.943-0.983, P = .001), ZAG (OR: 1.298, 95% CI: 1.121-1.401, P = .005), nesfatin-1 (OR: 0.876, 95% CI: 0.751-0.901, P = .002), and HbA1c (OR: 1.321, 95% CI: 1.121-1.401, P = .012) were independent risk factors for T2DM complicated with hypothyroidism.Regular detection of IGF-1, ZAG, nesfatin-1, and HbA1c levels are of great value for the diagnosis and treatment of patients with T2DM complicated with hypothyroidism.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000025432</identifier><identifier>PMID: 33847643</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adult ; Age Factors ; Blood Glucose ; Body Mass Index ; Comorbidity ; Diabetes Mellitus, Type 2 - epidemiology ; Female ; Glycated Hemoglobin - analysis ; Health Behavior ; Humans ; Hypothyroidism - epidemiology ; Insulin-Like Growth Factor I - analysis ; Male ; Middle Aged ; Nucleobindins - blood ; Observational Study ; Risk Factors ; Seminal Plasma Proteins - blood ; Sex Factors ; Zn-Alpha-2-Glycoprotein</subject><ispartof>Medicine (Baltimore), 2021-04, Vol.100 (15), p.e25432-e25432</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2959-38159558939104437c106b06b3aa2e11dceb7b666869d297112e5e00d4cdf2f43</citedby><cites>FETCH-LOGICAL-c2959-38159558939104437c106b06b3aa2e11dceb7b666869d297112e5e00d4cdf2f43</cites><orcidid>0000-0002-7876-9683</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052084/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052084/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33847643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Shuangling</creatorcontrib><creatorcontrib>He, Ying</creatorcontrib><creatorcontrib>Jin, Fenghua</creatorcontrib><creatorcontrib>Liu, Yanjie</creatorcontrib><title>Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus complicated with hypothyroidism</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus (T2DM) complicated with hypothyroidism.Fifty-five patients with type-2 diabetes who were admitted to our hospital from August 2018 to February 2020 were selected as the control group, and 55 patients with type 2 diabetes combined with hypothyroidism who were admitted to the hospital at the same period were selected as the combined group, and 56 patients who came to our hospital for physical examination at the same period were selected as the healthy group. The general clinical data and relevant laboratory indexes of all patients in the three groups were collected and statistically analyzed. Besides, the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and T2DM complicated with hypothyroidism was analyzed.Levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, TgAb, and HOMA-IR in the diabetes group and combined group were all significantly higher than those in the healthy group, while HDL and T4 levels in the diabetes group and combined group were lower than those in the healthy group (P < .05). The levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, and TgAb in the combined group were significantly higher than those in the diabetes group (P < .05), and the levels of HDL and T4 were lower than those in the diabetes group. In addition, the IGF-1 level was positively correlated with ZAG, nesfatin-1, and HbA1c levels in the combined group (P < .05), and IGF-1 (OR: 0.964, 95% CI: 0.943-0.983, P = .001), ZAG (OR: 1.298, 95% CI: 1.121-1.401, P = .005), nesfatin-1 (OR: 0.876, 95% CI: 0.751-0.901, P = .002), and HbA1c (OR: 1.321, 95% CI: 1.121-1.401, P = .012) were independent risk factors for T2DM complicated with hypothyroidism.Regular detection of IGF-1, ZAG, nesfatin-1, and HbA1c levels are of great value for the diagnosis and treatment of patients with T2DM complicated with hypothyroidism.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Blood Glucose</subject><subject>Body Mass Index</subject><subject>Comorbidity</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Female</subject><subject>Glycated Hemoglobin - analysis</subject><subject>Health Behavior</subject><subject>Humans</subject><subject>Hypothyroidism - epidemiology</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nucleobindins - blood</subject><subject>Observational Study</subject><subject>Risk Factors</subject><subject>Seminal Plasma Proteins - blood</subject><subject>Sex Factors</subject><subject>Zn-Alpha-2-Glycoprotein</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu1DAYhSMEokPhCZCQlywmxdck3iCNpu20Uis2sGFjOckfYnDiYDsdhafHw_QCWJYsHX_n-HKy7C3BZwTL8sPt-Rl-GlRwRp9lKyJYkQtZ8OfZ6qDmpSz5SfYqhO8YE1ZS_jI7YaziZcHZKvu1dd6D1dG4EelR2yWYgFyHrneXOVmjr5vdGo0QukSMB-Gq3pAGWbgDG9bJ0aK4TIAoao2uIUJAA1hr4hxQ44bJmkZHaNHexB71y-Riv3hnWhOG19mLTtsAb-7X0-zL5cXn7VV-82l3vd3c5A2VQuasIkIKUUkmCeaclQ3BRZ0m05oCIW0DdVkXRVEVsqWyJISCAIxb3rQd7Tg7zT4ec6e5HiDhY_TaqsmbQftFOW3Uvzuj6dU3d6cqLCiuDgHv7wO8-zlDiGowoUmv1CO4OSgqCGWc8apMKDuijXcheOgejyFYHVpTt-fq_9aS693fN3z0PNSUAH4E9s5G8OGHnffgVQ_axv5PniglzSmm6YtIgfOkMMl-A9-poYs</recordid><startdate>20210416</startdate><enddate>20210416</enddate><creator>He, Shuangling</creator><creator>He, Ying</creator><creator>Jin, Fenghua</creator><creator>Liu, Yanjie</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7876-9683</orcidid></search><sort><creationdate>20210416</creationdate><title>Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus complicated with hypothyroidism</title><author>He, Shuangling ; He, Ying ; Jin, Fenghua ; Liu, Yanjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2959-38159558939104437c106b06b3aa2e11dceb7b666869d297112e5e00d4cdf2f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Blood Glucose</topic><topic>Body Mass Index</topic><topic>Comorbidity</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Female</topic><topic>Glycated Hemoglobin - analysis</topic><topic>Health Behavior</topic><topic>Humans</topic><topic>Hypothyroidism - epidemiology</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nucleobindins - blood</topic><topic>Observational Study</topic><topic>Risk Factors</topic><topic>Seminal Plasma Proteins - blood</topic><topic>Sex Factors</topic><topic>Zn-Alpha-2-Glycoprotein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Shuangling</creatorcontrib><creatorcontrib>He, Ying</creatorcontrib><creatorcontrib>Jin, Fenghua</creatorcontrib><creatorcontrib>Liu, Yanjie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Shuangling</au><au>He, Ying</au><au>Jin, Fenghua</au><au>Liu, Yanjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus complicated with hypothyroidism</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-04-16</date><risdate>2021</risdate><volume>100</volume><issue>15</issue><spage>e25432</spage><epage>e25432</epage><pages>e25432-e25432</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus (T2DM) complicated with hypothyroidism.Fifty-five patients with type-2 diabetes who were admitted to our hospital from August 2018 to February 2020 were selected as the control group, and 55 patients with type 2 diabetes combined with hypothyroidism who were admitted to the hospital at the same period were selected as the combined group, and 56 patients who came to our hospital for physical examination at the same period were selected as the healthy group. The general clinical data and relevant laboratory indexes of all patients in the three groups were collected and statistically analyzed. Besides, the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and T2DM complicated with hypothyroidism was analyzed.Levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, TgAb, and HOMA-IR in the diabetes group and combined group were all significantly higher than those in the healthy group, while HDL and T4 levels in the diabetes group and combined group were lower than those in the healthy group (P < .05). The levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, and TgAb in the combined group were significantly higher than those in the diabetes group (P < .05), and the levels of HDL and T4 were lower than those in the diabetes group. In addition, the IGF-1 level was positively correlated with ZAG, nesfatin-1, and HbA1c levels in the combined group (P < .05), and IGF-1 (OR: 0.964, 95% CI: 0.943-0.983, P = .001), ZAG (OR: 1.298, 95% CI: 1.121-1.401, P = .005), nesfatin-1 (OR: 0.876, 95% CI: 0.751-0.901, P = .002), and HbA1c (OR: 1.321, 95% CI: 1.121-1.401, P = .012) were independent risk factors for T2DM complicated with hypothyroidism.Regular detection of IGF-1, ZAG, nesfatin-1, and HbA1c levels are of great value for the diagnosis and treatment of patients with T2DM complicated with hypothyroidism.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33847643</pmid><doi>10.1097/MD.0000000000025432</doi><orcidid>https://orcid.org/0000-0002-7876-9683</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Blood Glucose Body Mass Index Comorbidity Diabetes Mellitus, Type 2 - epidemiology Female Glycated Hemoglobin - analysis Health Behavior Humans Hypothyroidism - epidemiology Insulin-Like Growth Factor I - analysis Male Middle Aged Nucleobindins - blood Observational Study Risk Factors Seminal Plasma Proteins - blood Sex Factors Zn-Alpha-2-Glycoprotein |
| title | Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus complicated with hypothyroidism |
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