Transmitted HIV‐1 drug resistance in a large international cohort using next‐generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study

Objectives The aim of this analysis was to characterize transmitted drug resistance (TDR) in Strategic Timing of Antiretroviral Treatment (START) study participants by next‐generation sequencing (NGS), a sensitive assay capable of detecting low‐frequency variants. Methods Stored plasma from particip...

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Veröffentlicht in:	HIV medicine 2021-05, Vol.22 (5), p.360-371
Hauptverfasser:	Baxter, JD, Dunn, D, Tostevin, A, Marvig, RL, Bennedbæk, M, Cozzi‐Lepri, A, Sharma, S, Kozal, MJ, Gompels, M, Pinto, AN, Lundgren, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Drug resistance Drug Resistance, Viral - genetics Genotype High-Throughput Nucleotide Sequencing - methods HIV HIV drug resistance HIV Infections - drug therapy HIV Infections - epidemiology HIV-1 - genetics Human immunodeficiency virus Humans Integrase Mutation next‐generation sequencing Nucleoside reverse transcriptase inhibitors Population studies Protease inhibitors Proteinase inhibitors RNA-directed DNA polymerase Surveillance
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