Maize centromeric chromatin scales with changes in genome size
Abstract Centromeres are defined by the location of Centromeric Histone H3 (CENP-A/CENH3) which interacts with DNA to define the locations and sizes of functional centromeres. An analysis of 26 maize genomes including 110 fully assembled centromeric regions revealed positive relationships between ce...
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| Veröffentlicht in: | Genetics (Austin) 2021-04, Vol.217 (4) |
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| creator | Wang, Na Liu, Jianing Ricci, William A Gent, Jonathan I Dawe, R Kelly |
| description | Abstract
Centromeres are defined by the location of Centromeric Histone H3 (CENP-A/CENH3) which interacts with DNA to define the locations and sizes of functional centromeres. An analysis of 26 maize genomes including 110 fully assembled centromeric regions revealed positive relationships between centromere size and genome size. These effects are independent of variation in the amounts of the major centromeric satellite sequence CentC. We also backcrossed known centromeres into two different lines with larger genomes and observed consistent increases in functional centromere sizes for multiple centromeres. Although changes in centromere size involve changes in bound CENH3, we could not mimic the effect by overexpressing CENH3 by threefold. Literature from other fields demonstrate that changes in genome size affect protein levels, organelle size and cell size. Our data demonstrate that centromere size is among these scalable features, and that multiple limiting factors together contribute to a stable centromere size equilibrium. |
| doi_str_mv | 10.1093/genetics/iyab020 |
| format | Article |
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Centromeres are defined by the location of Centromeric Histone H3 (CENP-A/CENH3) which interacts with DNA to define the locations and sizes of functional centromeres. An analysis of 26 maize genomes including 110 fully assembled centromeric regions revealed positive relationships between centromere size and genome size. These effects are independent of variation in the amounts of the major centromeric satellite sequence CentC. We also backcrossed known centromeres into two different lines with larger genomes and observed consistent increases in functional centromere sizes for multiple centromeres. Although changes in centromere size involve changes in bound CENH3, we could not mimic the effect by overexpressing CENH3 by threefold. Literature from other fields demonstrate that changes in genome size affect protein levels, organelle size and cell size. Our data demonstrate that centromere size is among these scalable features, and that multiple limiting factors together contribute to a stable centromere size equilibrium.</description><identifier>ISSN: 1943-2631</identifier><identifier>ISSN: 0016-6731</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1093/genetics/iyab020</identifier><identifier>PMID: 33857306</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Cell size ; Centromere - genetics ; Centromere - metabolism ; Centromere protein A ; Centromeres ; Chromatin ; Chromatin - genetics ; Chromatin - metabolism ; Corn ; Deoxyribonucleic acid ; DNA ; Genetic Variation ; Genetics ; Genome Size ; Genomes ; Histone H3 ; Histones ; Histones - genetics ; Histones - metabolism ; Inbreeding ; Investigation ; Plant Proteins - genetics ; Plant Proteins - metabolism ; Zea mays - genetics</subject><ispartof>Genetics (Austin), 2021-04, Vol.217 (4)</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America. All rights reserved. For permissions, please email: journals.permissions@oup.com 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-5f1a173f7d349e5dd949eaeec51d473971fab15f36036bd4fa10a4d122c2d3713</citedby><cites>FETCH-LOGICAL-c460t-5f1a173f7d349e5dd949eaeec51d473971fab15f36036bd4fa10a4d122c2d3713</cites><orcidid>0000-0001-9296-1412</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,1581,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33857306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Britt, A</contributor><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Liu, Jianing</creatorcontrib><creatorcontrib>Ricci, William A</creatorcontrib><creatorcontrib>Gent, Jonathan I</creatorcontrib><creatorcontrib>Dawe, R Kelly</creatorcontrib><title>Maize centromeric chromatin scales with changes in genome size</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>Abstract
Centromeres are defined by the location of Centromeric Histone H3 (CENP-A/CENH3) which interacts with DNA to define the locations and sizes of functional centromeres. An analysis of 26 maize genomes including 110 fully assembled centromeric regions revealed positive relationships between centromere size and genome size. These effects are independent of variation in the amounts of the major centromeric satellite sequence CentC. We also backcrossed known centromeres into two different lines with larger genomes and observed consistent increases in functional centromere sizes for multiple centromeres. Although changes in centromere size involve changes in bound CENH3, we could not mimic the effect by overexpressing CENH3 by threefold. Literature from other fields demonstrate that changes in genome size affect protein levels, organelle size and cell size. Our data demonstrate that centromere size is among these scalable features, and that multiple limiting factors together contribute to a stable centromere size equilibrium.</description><subject>Cell size</subject><subject>Centromere - genetics</subject><subject>Centromere - metabolism</subject><subject>Centromere protein A</subject><subject>Centromeres</subject><subject>Chromatin</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>Corn</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>Genome Size</subject><subject>Genomes</subject><subject>Histone H3</subject><subject>Histones</subject><subject>Histones - genetics</subject><subject>Histones - metabolism</subject><subject>Inbreeding</subject><subject>Investigation</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - metabolism</subject><subject>Zea mays - genetics</subject><issn>1943-2631</issn><issn>0016-6731</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctLAzEQxoMotlbvnmTBiyBr89xsLoIUX1DxoueQTbJtynZTN7tK_euN9kH14mkmk998M8MHwCmCVwgKMpzY2rZOh6FbqgJiuAf6SFCS4oyg_Z28B45CmEEIM8HyQ9AjJGecwKwPrp-U-7SJtnXb-LltnE70NGaqdXUStKpsSD5cO41VVU_iI5bj1IgmITYeg4NSVcGerOMAvN7dvowe0vHz_ePoZpxqmsE2ZSVSiJOSG0KFZcaIGJS1miFDOREclapArCQZJFlhaKkQVNQgjDU2hCMyANcr3UVXzK35WVdVctG4uWqW0isnf__Ubion_l3mkAoWRwzAxVqg8W-dDa2cu6BtVana-i5IzBBlAuVYRPT8DzrzXVPH8yLFBWcQ5zRScEXpxofQ2HK7DILy2xy5MUeuzYktZ7tHbBs2bkTgcgX4bvG_3Bc6y52i</recordid><startdate>20210415</startdate><enddate>20210415</enddate><creator>Wang, Na</creator><creator>Liu, Jianing</creator><creator>Ricci, William A</creator><creator>Gent, Jonathan I</creator><creator>Dawe, R Kelly</creator><general>Oxford University Press</general><general>Genetics Society of America</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>4U-</scope><scope>7QP</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9296-1412</orcidid></search><sort><creationdate>20210415</creationdate><title>Maize centromeric chromatin scales with changes in genome size</title><author>Wang, Na ; Liu, Jianing ; Ricci, William A ; Gent, Jonathan I ; Dawe, R Kelly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-5f1a173f7d349e5dd949eaeec51d473971fab15f36036bd4fa10a4d122c2d3713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cell size</topic><topic>Centromere - genetics</topic><topic>Centromere - metabolism</topic><topic>Centromere protein A</topic><topic>Centromeres</topic><topic>Chromatin</topic><topic>Chromatin - genetics</topic><topic>Chromatin - metabolism</topic><topic>Corn</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Genetic Variation</topic><topic>Genetics</topic><topic>Genome Size</topic><topic>Genomes</topic><topic>Histone H3</topic><topic>Histones</topic><topic>Histones - genetics</topic><topic>Histones - metabolism</topic><topic>Inbreeding</topic><topic>Investigation</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - metabolism</topic><topic>Zea mays - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Liu, Jianing</creatorcontrib><creatorcontrib>Ricci, William A</creatorcontrib><creatorcontrib>Gent, Jonathan I</creatorcontrib><creatorcontrib>Dawe, R Kelly</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics (Austin)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Na</au><au>Liu, Jianing</au><au>Ricci, William A</au><au>Gent, Jonathan I</au><au>Dawe, R Kelly</au><au>Britt, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maize centromeric chromatin scales with changes in genome size</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>2021-04-15</date><risdate>2021</risdate><volume>217</volume><issue>4</issue><issn>1943-2631</issn><issn>0016-6731</issn><eissn>1943-2631</eissn><abstract>Abstract
Centromeres are defined by the location of Centromeric Histone H3 (CENP-A/CENH3) which interacts with DNA to define the locations and sizes of functional centromeres. An analysis of 26 maize genomes including 110 fully assembled centromeric regions revealed positive relationships between centromere size and genome size. These effects are independent of variation in the amounts of the major centromeric satellite sequence CentC. We also backcrossed known centromeres into two different lines with larger genomes and observed consistent increases in functional centromere sizes for multiple centromeres. Although changes in centromere size involve changes in bound CENH3, we could not mimic the effect by overexpressing CENH3 by threefold. Literature from other fields demonstrate that changes in genome size affect protein levels, organelle size and cell size. Our data demonstrate that centromere size is among these scalable features, and that multiple limiting factors together contribute to a stable centromere size equilibrium.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>33857306</pmid><doi>10.1093/genetics/iyab020</doi><orcidid>https://orcid.org/0000-0001-9296-1412</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cell size Centromere - genetics Centromere - metabolism Centromere protein A Centromeres Chromatin Chromatin - genetics Chromatin - metabolism Corn Deoxyribonucleic acid DNA Genetic Variation Genetics Genome Size Genomes Histone H3 Histones Histones - genetics Histones - metabolism Inbreeding Investigation Plant Proteins - genetics Plant Proteins - metabolism Zea mays - genetics |
| title | Maize centromeric chromatin scales with changes in genome size |
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