First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer

This was a first-in-human study of the PET radiotracer 11C-LSN3172176 for the muscarinic acetylcholine receptor subtype M1. The objectives of the study were to determine the appropriate kinetic model to quantify binding of the tracer to M1 receptors, and the reliability of the chosen quantification...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2021-04, Vol.62 (4), p.553-560
Hauptverfasser:	Naganawa, Mika, Nabulsi, Nabeel, Henry, Shannan, Matuskey, David, Lin, Shu-Fei, Slieker, Lawrence, Schwarz, Adam J, Kant, Nancy, Jesudason, Cynthia, Ruley, Kevin, Navarro, Antonio, Gao, Hong, Ropchan, Jim, Labaree, David, Carson, Richard E, Huang, Yiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Binding Brain Cerebellum Neostriatum Neuroimaging Neurology Occupancy Parameter estimation Positron emission tomography Radioactive tracers Receptors Scopolamine Substantia alba Tissues
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