Longitudinal Molecular Imaging of Progesterone Receptor Reveals Early Differential Response to Endocrine Therapy in Breast Cancer with an Activating ESR1 Mutation

Activating mutations in the estrogen receptor (ER) α-gene ( ) result in constitutive transcriptional activity in the absence of estrogen and are associated with endocrine resistance in metastatic ER-positive (+) breast cancer. It is not known how activating mutations may alter the predictive values...

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Veröffentlicht in:	Journal of Nuclear Medicine 2021-04, Vol.62 (4), p.500-506
Hauptverfasser:	Kumar, Manoj, Salem, Kelley, Jeffery, Justin J, Yan, Yongjun, Mahajan, Aparna M, Fowler, Amy M
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Cell Transformation, Neoplastic Computed tomography Endocrine therapy Estradiol - pharmacology Estradiol - therapeutic use Estrogen Receptor alpha - genetics Estrogen receptors Estrogens Estrogens - pharmacology Estrogens - therapeutic use Ethanol Female Fluorine isotopes Fluorodeoxyglucose F18 Fulvestrant Gene Expression Regulation, Neoplastic - drug effects Glucose metabolism Glycosylation - drug effects Growth curves Humans Immunodeficiency Longitudinal Studies Medical imaging Metabolic response Metastases Mice Mutation Oncology Ovariectomy Pharmaceuticals Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Progesterone Radiochemistry Radioisotopes Receptors Receptors, Progesterone - metabolism Sex hormones Therapy Tomography Transcription Treatment Outcome Tumors Variance analysis Xenografts Xenotransplantation
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