Mechanics of Porcine Heart Valves’ Strut Chordae Tendineae Investigated as a Leaflet–Chordae–Papillary Muscle Entity
Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is n...
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| Veröffentlicht in: | Annals of biomedical engineering 2020-05, Vol.48 (5), p.1463-1474 |
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| creator | Ross, Colton J. Laurence, Devin W. Hsu, Ming-Chen Baumwart, Ryan Zhao, Yan D. Mir, Arshid Burkhart, Harold M. Holzapfel, Gerhard A. Wu, Yi Lee, Chung-Hao |
| description | Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as
individual
structures, usually in a clamping-based approach, which may not accurately reflect the
in vivo
chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet–chordae–papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09–1.16, while peak stretches of 1.08–1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease. |
| doi_str_mv | 10.1007/s10439-020-02464-6 |
| format | Article |
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individual
structures, usually in a clamping-based approach, which may not accurately reflect the
in vivo
chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet–chordae–papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09–1.16, while peak stretches of 1.08–1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease.</description><identifier>ISSN: 0090-6964</identifier><identifier>ISSN: 1573-9686</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-020-02464-6</identifier><identifier>PMID: 32006267</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Biochemistry ; Biological and Medical Physics ; Biomechanical Phenomena ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Blood flow ; Cardiovascular diseases ; Chordae Tendineae - physiology ; Classical Mechanics ; Computer applications ; Coronary artery disease ; Heart ; Heart diseases ; Heart valves ; In vivo methods and tests ; Mathematical models ; Mechanical properties ; Mechanical tests ; Mechanics (physics) ; Mitral valve ; Mitral Valve - physiology ; Muscles ; Original Article ; Papillary Muscles - physiology ; Rheumatic heart disease ; Swine ; Tricuspid valve ; Tricuspid Valve - physiology</subject><ispartof>Annals of biomedical engineering, 2020-05, Vol.48 (5), p.1463-1474</ispartof><rights>Biomedical Engineering Society 2020</rights><rights>Biomedical Engineering Society 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-c2828252e37f1f8bb2eb392cf991b128d2417e6c03063bb64114d66453165f8a3</citedby><cites>FETCH-LOGICAL-c511t-c2828252e37f1f8bb2eb392cf991b128d2417e6c03063bb64114d66453165f8a3</cites><orcidid>0000-0002-8019-3329</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-020-02464-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-020-02464-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32006267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ross, Colton J.</creatorcontrib><creatorcontrib>Laurence, Devin W.</creatorcontrib><creatorcontrib>Hsu, Ming-Chen</creatorcontrib><creatorcontrib>Baumwart, Ryan</creatorcontrib><creatorcontrib>Zhao, Yan D.</creatorcontrib><creatorcontrib>Mir, Arshid</creatorcontrib><creatorcontrib>Burkhart, Harold M.</creatorcontrib><creatorcontrib>Holzapfel, Gerhard A.</creatorcontrib><creatorcontrib>Wu, Yi</creatorcontrib><creatorcontrib>Lee, Chung-Hao</creatorcontrib><title>Mechanics of Porcine Heart Valves’ Strut Chordae Tendineae Investigated as a Leaflet–Chordae–Papillary Muscle Entity</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as
individual
structures, usually in a clamping-based approach, which may not accurately reflect the
in vivo
chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet–chordae–papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09–1.16, while peak stretches of 1.08–1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Blood flow</subject><subject>Cardiovascular diseases</subject><subject>Chordae Tendineae - physiology</subject><subject>Classical Mechanics</subject><subject>Computer applications</subject><subject>Coronary artery disease</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heart valves</subject><subject>In vivo methods and tests</subject><subject>Mathematical models</subject><subject>Mechanical properties</subject><subject>Mechanical tests</subject><subject>Mechanics (physics)</subject><subject>Mitral valve</subject><subject>Mitral Valve - physiology</subject><subject>Muscles</subject><subject>Original Article</subject><subject>Papillary Muscles - physiology</subject><subject>Rheumatic heart disease</subject><subject>Swine</subject><subject>Tricuspid valve</subject><subject>Tricuspid Valve - 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Eng</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>48</volume><issue>5</issue><spage>1463</spage><epage>1474</epage><pages>1463-1474</pages><issn>0090-6964</issn><issn>1573-9686</issn><eissn>1573-9686</eissn><abstract>Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as
individual
structures, usually in a clamping-based approach, which may not accurately reflect the
in vivo
chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet–chordae–papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09–1.16, while peak stretches of 1.08–1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32006267</pmid><doi>10.1007/s10439-020-02464-6</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8019-3329</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry Biological and Medical Physics Biomechanical Phenomena Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Blood flow Cardiovascular diseases Chordae Tendineae - physiology Classical Mechanics Computer applications Coronary artery disease Heart Heart diseases Heart valves In vivo methods and tests Mathematical models Mechanical properties Mechanical tests Mechanics (physics) Mitral valve Mitral Valve - physiology Muscles Original Article Papillary Muscles - physiology Rheumatic heart disease Swine Tricuspid valve Tricuspid Valve - physiology |
| title | Mechanics of Porcine Heart Valves’ Strut Chordae Tendineae Investigated as a Leaflet–Chordae–Papillary Muscle Entity |
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