Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

Introduction The cytoprotective PTEN‐induced kinase 1 (PINK1)‐parkin RBR E3 ubiquitin protein ligase (PRKN) pathway selectively labels damaged mitochondria with phosphorylated ubiquitin (pS65‐Ub) for their autophagic removal (mitophagy). Because dysfunctions of mitochondria and degradation pathways...

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Veröffentlicht in:	Alzheimer's & dementia 2021-03, Vol.17 (3), p.417-430
Hauptverfasser:	Hou, Xu, Watzlawik, Jens O., Cook, Casey, Liu, Chia‐Chen, Kang, Silvia S., Lin, Wen‐Lang, DeTure, Michael, Heckman, Michael G., Diehl, Nancy N., Al‐Shaikh, Fadi S. Hanna, Walton, Ronald L., Ross, Owen A., Melrose, Heather L., Ertekin‐Taner, Nilüfer, Bu, Guojun, Petrucelli, Leonard, Fryer, John D., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease autophagy granulovacuolar degeneration lysosomes mitochondria mitophagy Parkin PINK1 PRKN tau ubiquitin
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