Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation

Many (poly‐)phenolic natural products, for example, curcumin and taxifolin, have been studied for their activity against specific hallmarks of neurodegeneration, such as amyloid‐β 42 (Aβ42) aggregation and neuroinflammation. Due to their drawbacks, arising from poor pharmacokinetics, rapid metabolis...

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Veröffentlicht in:	Chemistry : a European journal 2021-04, Vol.27 (19), p.6015-6027
Hauptverfasser:	Hofmann, Julian, Ginex, Tiziana, Espargaró, Alba, Scheiner, Matthias, Gunesch, Sandra, Aragó, Marc, Stigloher, Christian, Sabaté, Raimon, Luque, F. Javier, Decker, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Amyloid Amyloid - metabolism amyloid beta Amyloid beta-Peptides - metabolism Amyloidosis Apoptosis Aqueous solutions Azo compounds bioisosterism Biological activity Catechol Cell survival Chemistry Curcumin Curcumin - pharmacology Humans Hydrophobicity Inflammation Intracellular Metabolism Natural products Neurodegeneration neuroprotectivity Oxidative Stress Pharmacokinetics Pharmacology Phenolic compounds Phenols replica-exchange molecular dynamics Survival
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