Hydrogen‐Borrowing Alkylation of 1,2‐Amino Alcohols in the Synthesis of Enantioenriched γ‐Aminobutyric Acids

For the first time we have been able to employ enantiopure 1,2‐amino alcohols derived from abundant amino acids in C−C bond‐forming hydrogen‐borrowing alkylation reactions. These reactions are facilitated by the use of the aryl ketone Ph*COMe. Racemisation of the amine stereocentre during alkylation...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-03, Vol.60 (13), p.6981-6985
Hauptverfasser:	Hall, Christopher J. J., Goundry, William R. F., Donohoe, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Alkylation Amino acids amino alcohols catalysis Column chromatography Communication Communications Hydrogen hydrogen borrowing iridium Racemization Salts γ-Aminobutyric acid
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