Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain

Translation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for preclinical evaluation of the efficiency of novel therapies in combination with s...

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Veröffentlicht in:	Molecular medicine reports 2021-06, Vol.23 (6), Article 422
Hauptverfasser:	Ahmad, Farizan, Hyvärinen, Anna, Pirinen, Agnieszka, Olsson, Venla, Rummukainen, Jaana, Immonen, Arto, Närväinen, Johanna, Tuunanen, Pasi, Liimatainen, Timo, Kärkkäinen, Virve, Koistinaho, Jari, Ylä-Ηerttuala, Seppo
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Animals Brain - metabolism Brain - pathology Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain research Brain tumors Carcinogenesis Cell cycle Cell Proliferation Cells, Cultured Chemotherapy Clinical trials Cytomegalovirus Development and progression Disease Models, Animal Female Fentanyl Ganglioglioma - pathology Genetic engineering Genetic transformation Genetic Vectors Glial fibrillary acidic protein Glioma Gliomas Growth factors H-Ras protein Immunohistochemistry Laboratory animals Lentivirus Lentivirus - genetics Magnetic resonance imaging Methods Mice Mice, SCID Mice, Transgenic Microscopy Neural Stem Cells Oncogenes - genetics p53 Protein Pathogenesis Rabbits siRNA Stem cell transplantation Stem cells Tumors
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