Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV‑2 Spike Protein in a Viral Membrane

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates host cell entry by binding to angiotensin-converting enzyme 2 (ACE2) and is considered the major target for drug and vaccine development. We previously built fully glycosylated full-length SARS-CoV-2 S pro...

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Veröffentlicht in:	Journal of chemical theory and computation 2021-04, Vol.17 (4), p.2479-2487
Hauptverfasser:	Choi, Yeol Kyo, Cao, Yiwei, Frank, Martin, Woo, Hyeonuk, Park, Sang-Jun, Yeom, Min Sun, Croll, Tristan I, Seok, Chaok, Im, Wonpil
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 - metabolism Antibodies Antibodies - metabolism Binding Biomolecular Systems COVID-19 - metabolism Glycan Glycosylation Humans Membranes Molecular dynamics Molecular Dynamics Simulation Protein Binding Protein Conformation Protein Multimerization Proteins Receptors SARS-CoV-2 - chemistry SARS-CoV-2 - metabolism Severe acute respiratory syndrome coronavirus 2 Shielding Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - metabolism Viral diseases
Online-Zugang:	Volltext
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