Proteogenomic and metabolomic characterization of human glioblastoma

Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of genomic, proteomic, post-translational modification and metabolomic data on 99 treatment-naive GBMs provides insights to G...

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Veröffentlicht in:	Cancer cell 2021-04, Vol.39 (4), p.509-528.e20
Hauptverfasser:	Gritsenko, Marina A., Kyle, Jennifer E., Cao, Song, Rykunov, Dmitry, Cornwell, MacIntosh, Petralia, Francesca, Wu, Yige, Reva, Boris, Kawaler, Emily, Olsen, Lindsey K., Liang, Wen-Wei, Wendl, Michael C., Caravan, Wagma, Ji, Jiayi, Petyuk, Vladislav A., Moon, Jamie, Moore, Ronald J., Krek, Azra, Zhu, Houxiang, McMichael, Joshua F., Lu, Shuangjia, Baral, Jessika, Yao, Lijun, Zink, Erika, Bloodsworth, Kent J., Satpathy, Shankha, Boca, Simina M., Chen, Feng, Ketchum, Karen A., Boja, Emily S., Hiltke, Tara, Mani, D.R., Chen, Xi S., Li, Qing Kay, Kim, Albert H., Fenyö, David, Mesri, Mehdi, Resnick, Adam C., Wang, Pei, Chheda, Milan G., Barnholtz-Sloan, Jill S., Rodland, Karin D., Liu, Tao, Ding, Li, Bauer, Thomas, Borucki, Melissa, Burke, Meghan C., Cai, Shuang, Calinawan, Anna P., Carr, Steven A., Chan, Daniel W., Charamut, Alyssa, Chesla, David, Chowdhury, Shrabanti, Cieślik, Marcin P., Culpepper, Houston, Demir, Emek, Dhir, Rajiv, Duffy, Elizabeth, Edwards, Robert, Gabriel, Stacey, Gabrovski, Nikolay, Garofano, Luciano, Gillette, Michael A., Hannick, Linda I., Hindenach, Barbara, Hoadley, Katherine A., Hostetter, Galen, Huang, Chen, Jaehnig, Eric, Ji, Nan, Jones, Corbin D., Kaspera, Wojciech, Lei, Jonathan, Li, Kai, Liu, Hongwei, Lubínski, Jan, Malc, Ewa, Malovannaya, Anna, McGarvey, Peter B., McGee, John, Mieczkowski, Piotr, Modugno, Francesmary, Ozbek, Umut, Paulovich, Amanda G., Piehowski, Paul D., Polonskaya, Larisa, Pruetz, Barbara, Ramkissoon, Shakti, Riggins, Gregory, Stawicki, Jakub, Tabor, Dave, Tansil, Darlene, Traer, Elie, Vatanian, Negin, Webster, Alex, Wen, Bo, Whiteaker, Jeffrey R., Zhang, Liwei, Zhao, Grace
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES acetylome BASIC BIOLOGICAL SCIENCES Brain Neoplasms - metabolism Brain Neoplasms - pathology Computational Biology - methods CPTAC Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Humans lipidome metabolome Metabolomics - methods Mutation - genetics Phospholipase C gamma - genetics Phospholipase C gamma - metabolism Phosphorylation - physiology Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism proteogenomics Proteogenomics - methods proteomics Proteomics - methods signaling single nuclei RNA-seq
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