The front line of defence: a meta-analysis of apoplastic proteases in plant immunity
Abstract Secreted proteases act at the front line of defence and play pivotal roles in disease resistance. However, the criteria for apoplastic immune proteases are not always defined and followed. Here, we critically reviewed 46 apoplastic proteases that function in plant defence. We found that mos...
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| Veröffentlicht in: | Journal of experimental botany 2021-04, Vol.72 (9), p.3381-3394 |
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| container_title | Journal of experimental botany |
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| creator | Godson, Alice van der Hoorn, Renier A L |
| description | Abstract
Secreted proteases act at the front line of defence and play pivotal roles in disease resistance. However, the criteria for apoplastic immune proteases are not always defined and followed. Here, we critically reviewed 46 apoplastic proteases that function in plant defence. We found that most apoplastic immune proteases are induced upon infection, and 17 proteases are genetically required for the immune response. Proteolytic activity has been confirmed for most of the proteases but is rarely shown to be required for biological function, and the apoplastic location of proteases can be subjective and dynamic. Pathogen-derived inhibitors have only been described for cysteine and serine proteases, and the selection pressure acting on immune proteases is rarely investigated. We discuss six different mechanisms by which these proteases mediate plant immunity and summarize the challenges for future research.
This meta-analysis discusses 46 known apoplastic immune proteases for their apoplastic location, protease activity, and their contribution to immunity, and identifies six different mechanisms for proteases acting in immunity. |
| doi_str_mv | 10.1093/jxb/eraa602 |
| format | Article |
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Secreted proteases act at the front line of defence and play pivotal roles in disease resistance. However, the criteria for apoplastic immune proteases are not always defined and followed. Here, we critically reviewed 46 apoplastic proteases that function in plant defence. We found that most apoplastic immune proteases are induced upon infection, and 17 proteases are genetically required for the immune response. Proteolytic activity has been confirmed for most of the proteases but is rarely shown to be required for biological function, and the apoplastic location of proteases can be subjective and dynamic. Pathogen-derived inhibitors have only been described for cysteine and serine proteases, and the selection pressure acting on immune proteases is rarely investigated. We discuss six different mechanisms by which these proteases mediate plant immunity and summarize the challenges for future research.
This meta-analysis discusses 46 known apoplastic immune proteases for their apoplastic location, protease activity, and their contribution to immunity, and identifies six different mechanisms for proteases acting in immunity.</description><identifier>ISSN: 0022-0957</identifier><identifier>EISSN: 1460-2431</identifier><identifier>DOI: 10.1093/jxb/eraa602</identifier><identifier>PMID: 33462613</identifier><language>eng</language><publisher>UK: Oxford University Press</publisher><subject>Disease Resistance ; Peptide Hydrolases - metabolism ; Plant Diseases ; Plant Immunity ; Plants - metabolism ; Proteolysis ; Review Papers</subject><ispartof>Journal of experimental botany, 2021-04, Vol.72 (9), p.3381-3394</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Experimental Biology. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Experimental Biology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-f031c9b75c6f229b78af7f0403df48a3b08c85f50cf193232e4643a1d2bf30ae3</citedby><cites>FETCH-LOGICAL-c342t-f031c9b75c6f229b78af7f0403df48a3b08c85f50cf193232e4643a1d2bf30ae3</cites><orcidid>0000-0002-3692-7487</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33462613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Klemenčič, Marina</contributor><creatorcontrib>Godson, Alice</creatorcontrib><creatorcontrib>van der Hoorn, Renier A L</creatorcontrib><title>The front line of defence: a meta-analysis of apoplastic proteases in plant immunity</title><title>Journal of experimental botany</title><addtitle>J Exp Bot</addtitle><description>Abstract
Secreted proteases act at the front line of defence and play pivotal roles in disease resistance. However, the criteria for apoplastic immune proteases are not always defined and followed. Here, we critically reviewed 46 apoplastic proteases that function in plant defence. We found that most apoplastic immune proteases are induced upon infection, and 17 proteases are genetically required for the immune response. Proteolytic activity has been confirmed for most of the proteases but is rarely shown to be required for biological function, and the apoplastic location of proteases can be subjective and dynamic. Pathogen-derived inhibitors have only been described for cysteine and serine proteases, and the selection pressure acting on immune proteases is rarely investigated. We discuss six different mechanisms by which these proteases mediate plant immunity and summarize the challenges for future research.
This meta-analysis discusses 46 known apoplastic immune proteases for their apoplastic location, protease activity, and their contribution to immunity, and identifies six different mechanisms for proteases acting in immunity.</description><subject>Disease Resistance</subject><subject>Peptide Hydrolases - metabolism</subject><subject>Plant Diseases</subject><subject>Plant Immunity</subject><subject>Plants - metabolism</subject><subject>Proteolysis</subject><subject>Review Papers</subject><issn>0022-0957</issn><issn>1460-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc9LHTEQx4O06NP21HvJqQiydfJjf_VQKGJVELw8z2E2b1Iju5ttsit9_72R9yr20lNC5sMnM_Nl7JOArwJadf74pzuniFiBPGAroSsopFbiHVsBSFlAW9ZH7DilRwAooSwP2ZFSupKVUCu2Xj8QdzGMM-_9SDw4viFHo6VvHPlAMxY4Yr9NPr3UcApTj2n2lk8xzISJEvcjz4_Z4IdhGf28_cDeO-wTfdyfJ-z-5-X64rq4vbu6ufhxW1il5Vw4UMK2XV3aykmZLw262oEGtXG6QdVBY5vSlWCdaJVUknSlFYqN7JwCJHXCvu-809INtLE0zhF7M0U_YNyagN78Wxn9g_kVnkwDWtalzILTvSCG3wul2Qw-WerzNBSWZKSuW9AK6jajZzvUxpBSJPf6jQDzkoPJOZh9Dpn-_LazV_bv4jPwZQeEZfqv6RlMzpMQ</recordid><startdate>20210413</startdate><enddate>20210413</enddate><creator>Godson, Alice</creator><creator>van der Hoorn, Renier A L</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3692-7487</orcidid></search><sort><creationdate>20210413</creationdate><title>The front line of defence: a meta-analysis of apoplastic proteases in plant immunity</title><author>Godson, Alice ; van der Hoorn, Renier A L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-f031c9b75c6f229b78af7f0403df48a3b08c85f50cf193232e4643a1d2bf30ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Disease Resistance</topic><topic>Peptide Hydrolases - metabolism</topic><topic>Plant Diseases</topic><topic>Plant Immunity</topic><topic>Plants - metabolism</topic><topic>Proteolysis</topic><topic>Review Papers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godson, Alice</creatorcontrib><creatorcontrib>van der Hoorn, Renier A L</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of experimental botany</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godson, Alice</au><au>van der Hoorn, Renier A L</au><au>Klemenčič, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The front line of defence: a meta-analysis of apoplastic proteases in plant immunity</atitle><jtitle>Journal of experimental botany</jtitle><addtitle>J Exp Bot</addtitle><date>2021-04-13</date><risdate>2021</risdate><volume>72</volume><issue>9</issue><spage>3381</spage><epage>3394</epage><pages>3381-3394</pages><issn>0022-0957</issn><eissn>1460-2431</eissn><abstract>Abstract
Secreted proteases act at the front line of defence and play pivotal roles in disease resistance. However, the criteria for apoplastic immune proteases are not always defined and followed. Here, we critically reviewed 46 apoplastic proteases that function in plant defence. We found that most apoplastic immune proteases are induced upon infection, and 17 proteases are genetically required for the immune response. Proteolytic activity has been confirmed for most of the proteases but is rarely shown to be required for biological function, and the apoplastic location of proteases can be subjective and dynamic. Pathogen-derived inhibitors have only been described for cysteine and serine proteases, and the selection pressure acting on immune proteases is rarely investigated. We discuss six different mechanisms by which these proteases mediate plant immunity and summarize the challenges for future research.
This meta-analysis discusses 46 known apoplastic immune proteases for their apoplastic location, protease activity, and their contribution to immunity, and identifies six different mechanisms for proteases acting in immunity.</abstract><cop>UK</cop><pub>Oxford University Press</pub><pmid>33462613</pmid><doi>10.1093/jxb/eraa602</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3692-7487</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Disease Resistance Peptide Hydrolases - metabolism Plant Diseases Plant Immunity Plants - metabolism Proteolysis Review Papers |
| title | The front line of defence: a meta-analysis of apoplastic proteases in plant immunity |
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