SLCO1B1 : Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function

( ) is an important transmembrane hepatic uptake transporter. Genetic variants in the gene have been associated with altered protein folding, resulting in protein degradation and decreased transporter activity. Next-generation sequencing (NGS) of pharmacogenes is being applied increasingly to associ...

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Veröffentlicht in:	Drug metabolism and disposition 2021-05, Vol.49 (5), p.395-404
Hauptverfasser:	Zhang, Lingxin, Sarangi, Vivekananda, Ho, Ming-Fen, Moon, Irene, Kalari, Krishna R, Wang, Liewei, Weinshilboum, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Variation - genetics Genomics - methods HEK293 Cells Humans Liver-Specific Organic Anion Transporter 1 - genetics Mutation, Missense - genetics
Online-Zugang:	Volltext
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