Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study
Purpose To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain 18 F-2-fluoro-2-deoxy- d -glucose-PET ( 18 F-FDG-PET). Methods Three hundred ninety ALS cases with King’s stages 1, 2, and 3 ( n = 390), i.e., involvement...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2021-04, Vol.48 (4), p.1124-1133 |
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| creator | Canosa, Antonio Calvo, Andrea Moglia, Cristina Manera, Umberto Vasta, Rosario Di Pede, Francesca Cabras, Sara Nardo, Davide Arena, Vincenzo Grassano, Maurizio D’Ovidio, Fabrizio Van Laere, Koen Van Damme, Philip Pagani, Marco Chiò, Adriano |
| description | Purpose
To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain
18
F-2-fluoro-2-deoxy-
d
-glucose-PET (
18
F-FDG-PET).
Methods
Three hundred ninety ALS cases with King’s stages 1, 2, and 3 (
n
= 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent brain
18
F-FDG-PET at diagnosis. King’s stage at PET was derived from ALSFRS-R and was regressed out against whole-brain metabolism in the whole sample. The full factorial design confirmed the hypothesis that differences among groups (King’s 1, King’s 2, King’s 3, and 40 healthy controls (HC)) existed overall. Comparisons among stages and between each group and HC were performed. We included age at PET and sex as covariates.
Results
Brain metabolism was inversely correlated with stage in medial frontal gyrus bilaterally, and right precentral and postcentral gyri. The full factorial design resulted in a significant main effect of groups. There was no significant difference between stages 1 and 2. Comparing stage 3 to stage 1+2, a significant relative hypometabolism was highlighted in the former in the left precentral and medial frontal gyri, and in the right medial frontal, postcentral, precentral, and middle frontal gyri. The comparisons between each group and HC showed the extension of frontal metabolic changes from stage 1 to stage 3, with the larger metabolic gap between stages 2 and 3.
Conclusions
Our findings support the hypothesis that in ALS, the propagation of neurodegeneration follows a corticofugal, regional ordered pattern, extending from the motor cortex to posterior and anterior regions. |
| doi_str_mv | 10.1007/s00259-020-05053-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8041703</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449252001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c296w-bd6cfac0c9c90500451263217e9e6bec99742acc4f5a1386fb376132e3db6dfb3</originalsourceid><addsrcrecordid>eNp9kbFu1TAUhiMEoqXwAkyWWFhcju04iRmQoKKAqMQCs-U4Tq4rJw52wiUbD8HS1-NJOO2timBg8rH9_b99zl8UTxmcMoD6RQbgUlHgQEGCFHR_rzhmFVO0hkbdv6trOCoe5XwJwBreqIfFkRDAVSXL4-Lnm2T8REa3mDYGb4ndmWlwmRibYs7ko5-GXz-uMsmLuT5G1oxbXFKcd0gHs7hkAsk2OOR9fkkMYc055bQPa0wRi87F7xvt6BBWG7OjM3Kon4gbfc4eiyWOcUhm3m34zNptj4sHvQnZPbldT4ov528_n72nF5_efTh7fUEt_n5P266yvbFglVU4ACgl45XgrHbKVa2zStUlN9aWvTRMNFXfirpigjvRtVWHu5Pi1cF3XtvRddZNCzaj5-RHkzYdjdd_30x-p4f4TTdQshoEGjy_NUjx6-ryorEl60Iwk4tr1rwsFZccB4_os3_Qy7imCdvTXDIma6UAkOIH6mb6yfV3n2Ggr0PXh9A1hq5vQtd7FImDKCOM4aU_1v9R_Qb8C7La</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2511579900</pqid></control><display><type>article</type><title>Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Canosa, Antonio ; Calvo, Andrea ; Moglia, Cristina ; Manera, Umberto ; Vasta, Rosario ; Di Pede, Francesca ; Cabras, Sara ; Nardo, Davide ; Arena, Vincenzo ; Grassano, Maurizio ; D’Ovidio, Fabrizio ; Van Laere, Koen ; Van Damme, Philip ; Pagani, Marco ; Chiò, Adriano</creator><creatorcontrib>Canosa, Antonio ; Calvo, Andrea ; Moglia, Cristina ; Manera, Umberto ; Vasta, Rosario ; Di Pede, Francesca ; Cabras, Sara ; Nardo, Davide ; Arena, Vincenzo ; Grassano, Maurizio ; D’Ovidio, Fabrizio ; Van Laere, Koen ; Van Damme, Philip ; Pagani, Marco ; Chiò, Adriano</creatorcontrib><description>Purpose
To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain
18
F-2-fluoro-2-deoxy-
d
-glucose-PET (
18
F-FDG-PET).
Methods
Three hundred ninety ALS cases with King’s stages 1, 2, and 3 (
n
= 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent brain
18
F-FDG-PET at diagnosis. King’s stage at PET was derived from ALSFRS-R and was regressed out against whole-brain metabolism in the whole sample. The full factorial design confirmed the hypothesis that differences among groups (King’s 1, King’s 2, King’s 3, and 40 healthy controls (HC)) existed overall. Comparisons among stages and between each group and HC were performed. We included age at PET and sex as covariates.
Results
Brain metabolism was inversely correlated with stage in medial frontal gyrus bilaterally, and right precentral and postcentral gyri. The full factorial design resulted in a significant main effect of groups. There was no significant difference between stages 1 and 2. Comparing stage 3 to stage 1+2, a significant relative hypometabolism was highlighted in the former in the left precentral and medial frontal gyri, and in the right medial frontal, postcentral, precentral, and middle frontal gyri. The comparisons between each group and HC showed the extension of frontal metabolic changes from stage 1 to stage 3, with the larger metabolic gap between stages 2 and 3.
Conclusions
Our findings support the hypothesis that in ALS, the propagation of neurodegeneration follows a corticofugal, regional ordered pattern, extending from the motor cortex to posterior and anterior regions.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-020-05053-w</identifier><identifier>PMID: 33029654</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amyotrophic lateral sclerosis ; Brain ; Cardiology ; Cortex (motor) ; Emission analysis ; Factorial design ; Fluorine isotopes ; Frontal gyrus ; Glucose ; Hypometabolism ; Hypotheses ; Imaging ; Medicine ; Medicine & Public Health ; Metabolism ; Neurodegeneration ; Neurology ; Nuclear Medicine ; Oncology ; Original ; Original Article ; Orthopedics ; Positron emission ; Positron emission tomography ; Radiology ; Tomography</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2021-04, Vol.48 (4), p.1124-1133</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c296w-bd6cfac0c9c90500451263217e9e6bec99742acc4f5a1386fb376132e3db6dfb3</citedby><cites>FETCH-LOGICAL-c296w-bd6cfac0c9c90500451263217e9e6bec99742acc4f5a1386fb376132e3db6dfb3</cites><orcidid>0000-0001-5876-4079</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-020-05053-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-020-05053-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27907,27908,41471,42540,51302</link.rule.ids></links><search><creatorcontrib>Canosa, Antonio</creatorcontrib><creatorcontrib>Calvo, Andrea</creatorcontrib><creatorcontrib>Moglia, Cristina</creatorcontrib><creatorcontrib>Manera, Umberto</creatorcontrib><creatorcontrib>Vasta, Rosario</creatorcontrib><creatorcontrib>Di Pede, Francesca</creatorcontrib><creatorcontrib>Cabras, Sara</creatorcontrib><creatorcontrib>Nardo, Davide</creatorcontrib><creatorcontrib>Arena, Vincenzo</creatorcontrib><creatorcontrib>Grassano, Maurizio</creatorcontrib><creatorcontrib>D’Ovidio, Fabrizio</creatorcontrib><creatorcontrib>Van Laere, Koen</creatorcontrib><creatorcontrib>Van Damme, Philip</creatorcontrib><creatorcontrib>Pagani, Marco</creatorcontrib><creatorcontrib>Chiò, Adriano</creatorcontrib><title>Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain
18
F-2-fluoro-2-deoxy-
d
-glucose-PET (
18
F-FDG-PET).
Methods
Three hundred ninety ALS cases with King’s stages 1, 2, and 3 (
n
= 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent brain
18
F-FDG-PET at diagnosis. King’s stage at PET was derived from ALSFRS-R and was regressed out against whole-brain metabolism in the whole sample. The full factorial design confirmed the hypothesis that differences among groups (King’s 1, King’s 2, King’s 3, and 40 healthy controls (HC)) existed overall. Comparisons among stages and between each group and HC were performed. We included age at PET and sex as covariates.
Results
Brain metabolism was inversely correlated with stage in medial frontal gyrus bilaterally, and right precentral and postcentral gyri. The full factorial design resulted in a significant main effect of groups. There was no significant difference between stages 1 and 2. Comparing stage 3 to stage 1+2, a significant relative hypometabolism was highlighted in the former in the left precentral and medial frontal gyri, and in the right medial frontal, postcentral, precentral, and middle frontal gyri. The comparisons between each group and HC showed the extension of frontal metabolic changes from stage 1 to stage 3, with the larger metabolic gap between stages 2 and 3.
Conclusions
Our findings support the hypothesis that in ALS, the propagation of neurodegeneration follows a corticofugal, regional ordered pattern, extending from the motor cortex to posterior and anterior regions.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Brain</subject><subject>Cardiology</subject><subject>Cortex (motor)</subject><subject>Emission analysis</subject><subject>Factorial design</subject><subject>Fluorine isotopes</subject><subject>Frontal gyrus</subject><subject>Glucose</subject><subject>Hypometabolism</subject><subject>Hypotheses</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Neurodegeneration</subject><subject>Neurology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Radiology</subject><subject>Tomography</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kbFu1TAUhiMEoqXwAkyWWFhcju04iRmQoKKAqMQCs-U4Tq4rJw52wiUbD8HS1-NJOO2timBg8rH9_b99zl8UTxmcMoD6RQbgUlHgQEGCFHR_rzhmFVO0hkbdv6trOCoe5XwJwBreqIfFkRDAVSXL4-Lnm2T8REa3mDYGb4ndmWlwmRibYs7ko5-GXz-uMsmLuT5G1oxbXFKcd0gHs7hkAsk2OOR9fkkMYc055bQPa0wRi87F7xvt6BBWG7OjM3Kon4gbfc4eiyWOcUhm3m34zNptj4sHvQnZPbldT4ov528_n72nF5_efTh7fUEt_n5P266yvbFglVU4ACgl45XgrHbKVa2zStUlN9aWvTRMNFXfirpigjvRtVWHu5Pi1cF3XtvRddZNCzaj5-RHkzYdjdd_30x-p4f4TTdQshoEGjy_NUjx6-ryorEl60Iwk4tr1rwsFZccB4_os3_Qy7imCdvTXDIma6UAkOIH6mb6yfV3n2Ggr0PXh9A1hq5vQtd7FImDKCOM4aU_1v9R_Qb8C7La</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Canosa, Antonio</creator><creator>Calvo, Andrea</creator><creator>Moglia, Cristina</creator><creator>Manera, Umberto</creator><creator>Vasta, Rosario</creator><creator>Di Pede, Francesca</creator><creator>Cabras, Sara</creator><creator>Nardo, Davide</creator><creator>Arena, Vincenzo</creator><creator>Grassano, Maurizio</creator><creator>D’Ovidio, Fabrizio</creator><creator>Van Laere, Koen</creator><creator>Van Damme, Philip</creator><creator>Pagani, Marco</creator><creator>Chiò, Adriano</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5876-4079</orcidid></search><sort><creationdate>20210401</creationdate><title>Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study</title><author>Canosa, Antonio ; Calvo, Andrea ; Moglia, Cristina ; Manera, Umberto ; Vasta, Rosario ; Di Pede, Francesca ; Cabras, Sara ; Nardo, Davide ; Arena, Vincenzo ; Grassano, Maurizio ; D’Ovidio, Fabrizio ; Van Laere, Koen ; Van Damme, Philip ; Pagani, Marco ; Chiò, Adriano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296w-bd6cfac0c9c90500451263217e9e6bec99742acc4f5a1386fb376132e3db6dfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amyotrophic lateral sclerosis</topic><topic>Brain</topic><topic>Cardiology</topic><topic>Cortex (motor)</topic><topic>Emission analysis</topic><topic>Factorial design</topic><topic>Fluorine isotopes</topic><topic>Frontal gyrus</topic><topic>Glucose</topic><topic>Hypometabolism</topic><topic>Hypotheses</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Neurodegeneration</topic><topic>Neurology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Radiology</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canosa, Antonio</creatorcontrib><creatorcontrib>Calvo, Andrea</creatorcontrib><creatorcontrib>Moglia, Cristina</creatorcontrib><creatorcontrib>Manera, Umberto</creatorcontrib><creatorcontrib>Vasta, Rosario</creatorcontrib><creatorcontrib>Di Pede, Francesca</creatorcontrib><creatorcontrib>Cabras, Sara</creatorcontrib><creatorcontrib>Nardo, Davide</creatorcontrib><creatorcontrib>Arena, Vincenzo</creatorcontrib><creatorcontrib>Grassano, Maurizio</creatorcontrib><creatorcontrib>D’Ovidio, Fabrizio</creatorcontrib><creatorcontrib>Van Laere, Koen</creatorcontrib><creatorcontrib>Van Damme, Philip</creatorcontrib><creatorcontrib>Pagani, Marco</creatorcontrib><creatorcontrib>Chiò, Adriano</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canosa, Antonio</au><au>Calvo, Andrea</au><au>Moglia, Cristina</au><au>Manera, Umberto</au><au>Vasta, Rosario</au><au>Di Pede, Francesca</au><au>Cabras, Sara</au><au>Nardo, Davide</au><au>Arena, Vincenzo</au><au>Grassano, Maurizio</au><au>D’Ovidio, Fabrizio</au><au>Van Laere, Koen</au><au>Van Damme, Philip</au><au>Pagani, Marco</au><au>Chiò, Adriano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><date>2021-04-01</date><risdate>2021</risdate><volume>48</volume><issue>4</issue><spage>1124</spage><epage>1133</epage><pages>1124-1133</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain
18
F-2-fluoro-2-deoxy-
d
-glucose-PET (
18
F-FDG-PET).
Methods
Three hundred ninety ALS cases with King’s stages 1, 2, and 3 (
n
= 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent brain
18
F-FDG-PET at diagnosis. King’s stage at PET was derived from ALSFRS-R and was regressed out against whole-brain metabolism in the whole sample. The full factorial design confirmed the hypothesis that differences among groups (King’s 1, King’s 2, King’s 3, and 40 healthy controls (HC)) existed overall. Comparisons among stages and between each group and HC were performed. We included age at PET and sex as covariates.
Results
Brain metabolism was inversely correlated with stage in medial frontal gyrus bilaterally, and right precentral and postcentral gyri. The full factorial design resulted in a significant main effect of groups. There was no significant difference between stages 1 and 2. Comparing stage 3 to stage 1+2, a significant relative hypometabolism was highlighted in the former in the left precentral and medial frontal gyri, and in the right medial frontal, postcentral, precentral, and middle frontal gyri. The comparisons between each group and HC showed the extension of frontal metabolic changes from stage 1 to stage 3, with the larger metabolic gap between stages 2 and 3.
Conclusions
Our findings support the hypothesis that in ALS, the propagation of neurodegeneration follows a corticofugal, regional ordered pattern, extending from the motor cortex to posterior and anterior regions.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33029654</pmid><doi>10.1007/s00259-020-05053-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5876-4079</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2021-04, Vol.48 (4), p.1124-1133 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8041703 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Amyotrophic lateral sclerosis Brain Cardiology Cortex (motor) Emission analysis Factorial design Fluorine isotopes Frontal gyrus Glucose Hypometabolism Hypotheses Imaging Medicine Medicine & Public Health Metabolism Neurodegeneration Neurology Nuclear Medicine Oncology Original Original Article Orthopedics Positron emission Positron emission tomography Radiology Tomography |
| title | Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study |
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