Rare, Protein-Altering Variants in AS3MT and Arsenic Metabolism Efficiency: A Multi-Population Association Study

Common genetic variation in the arsenic methyltransferase ( ) gene region is known to be associated with arsenic metabolism efficiency (AME), measured as the percentage of dimethylarsinic acid (DMA%) in the urine. Rare, protein-altering variants in could have even larger effects on AME, but their co...

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Veröffentlicht in:	Environmental health perspectives 2021-04, Vol.129 (4), p.47007
Hauptverfasser:	Delgado, Dayana A, Chernoff, Meytal, Huang, Lei, Tong, Lin, Chen, Lin, Jasmine, Farzana, Shinkle, Justin, Cole, Shelley A, Haack, Karin, Kent, Jack, Umans, Jason, Best, Lyle G, Nelson, Heather, Griend, Donald Vander, Graziano, Joseph, Kibriya, Muhammad G, Navas-Acien, Ana, Karagas, Margaret R, Ahsan, Habibul, Pierce, Brandon L
Format:	Artikel
Sprache:	eng
Schlagworte:	Age composition Alleles Arsenic Cacodylic Acid Cardiovascular disease Cohort analysis Dimethylarsinic acid DNA methylation DNA sequencing Drinking water Gene frequency Genetic diversity Longitudinal Studies Metabolism Metabolites Methyltransferase Methyltransferases - genetics Native North Americans Polymorphism, Single Nucleotide Population structure Population studies Population-based studies Proteins Skin Skin cancer Toxicity Urine
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