Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of E...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2021-01, Vol.371 (6525) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6525 |
| container_start_page | |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 371 |
| creator | Roark, Ryan S Li, Hui Williams, Wilton B Chug, Hema Mason, Rosemarie D Gorman, Jason Wang, Shuyi Lee, Fang-Hua Rando, Juliette Bonsignori, Mattia Hwang, Kwan-Ki Saunders, Kevin O Wiehe, Kevin Moody, M Anthony Hraber, Peter T Wagh, Kshitij Giorgi, Elena E Russell, Ronnie M Bibollet-Ruche, Frederic Liu, Weimin Connell, Jesse Smith, Andrew G DeVoto, Julia Murphy, Alexander I Smith, Jessica Ding, Wenge Zhao, Chengyan Chohan, Neha Okumura, Maho Rosario, Christina Ding, Yu Lindemuth, Emily Bauer, Anya M Bar, Katharine J Ambrozak, David Chao, Cara W Chuang, Gwo-Yu Geng, Hui Lin, Bob C Louder, Mark K Nguyen, Richard Zhang, Baoshan Lewis, Mark G Raymond, Donald D Doria-Rose, Nicole A Schramm, Chaim A Douek, Daniel C Roederer, Mario Kepler, Thomas B Kelsoe, Garnett Mascola, John R Kwong, Peter D Korber, Bette T Harrison, Stephen C Haynes, Barton F Hahn, Beatrice H Shaw, George M |
| description | Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S. Another rhesus antibody bound the CD4 binding site by CD4 mimicry, mirroring human bNAbs 8ANC131, CH235, and VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design. |
| doi_str_mv | 10.1126/science.abd2638 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8040783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2463099990</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-703b00fd349b51e512a64d36681720d7e698695db009107777b536fdea88fb313</originalsourceid><addsrcrecordid>eNpdkc1LAzEQxYMotn6cvcmCFy-rk2Q3m70IUqoWBEHUoyGbZDVlm9TNbqH-9aa2FnUuc3i_eczjIXSC4QJjwi6DssYpcyErTRjlO2iIoczTkgDdRUMAylIORT5AByFMAaJW0n00oJTgjPBiiF4fjZJz2_WN7Kx3ia-Tu8lLipOxW6TSdbbyepkobxa-6b8J65KZVPKjNyFpjNTWvSWdT5zpu1Y29nPtU7VR6t6P0F4tm2CON_sQPd-Mn0Z36f3D7WR0fZ-qjOAuLYBWALWmWVnl2OSYSJZpyhjHBQFdGFZyVuY6QiWGIk6VU1ZrIzmvK4rpIbpa-877ama0Mm71jJi3dibbpfDSir-Ks-_izS8EhwwKTqPB-cag9atonZjZoEzTSGd8HwTJGIUyDkT07B869X3rYrwVRbIikiRSl2tKtT6E1tTbZzCIVXdi053YdBcvTn9n2PI_ZdEv0aiX0A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2462476302</pqid></control><display><type>article</type><title>Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth</title><source>American Association for the Advancement of Science</source><source>MEDLINE</source><creator>Roark, Ryan S ; Li, Hui ; Williams, Wilton B ; Chug, Hema ; Mason, Rosemarie D ; Gorman, Jason ; Wang, Shuyi ; Lee, Fang-Hua ; Rando, Juliette ; Bonsignori, Mattia ; Hwang, Kwan-Ki ; Saunders, Kevin O ; Wiehe, Kevin ; Moody, M Anthony ; Hraber, Peter T ; Wagh, Kshitij ; Giorgi, Elena E ; Russell, Ronnie M ; Bibollet-Ruche, Frederic ; Liu, Weimin ; Connell, Jesse ; Smith, Andrew G ; DeVoto, Julia ; Murphy, Alexander I ; Smith, Jessica ; Ding, Wenge ; Zhao, Chengyan ; Chohan, Neha ; Okumura, Maho ; Rosario, Christina ; Ding, Yu ; Lindemuth, Emily ; Bauer, Anya M ; Bar, Katharine J ; Ambrozak, David ; Chao, Cara W ; Chuang, Gwo-Yu ; Geng, Hui ; Lin, Bob C ; Louder, Mark K ; Nguyen, Richard ; Zhang, Baoshan ; Lewis, Mark G ; Raymond, Donald D ; Doria-Rose, Nicole A ; Schramm, Chaim A ; Douek, Daniel C ; Roederer, Mario ; Kepler, Thomas B ; Kelsoe, Garnett ; Mascola, John R ; Kwong, Peter D ; Korber, Bette T ; Harrison, Stephen C ; Haynes, Barton F ; Hahn, Beatrice H ; Shaw, George M</creator><creatorcontrib>Roark, Ryan S ; Li, Hui ; Williams, Wilton B ; Chug, Hema ; Mason, Rosemarie D ; Gorman, Jason ; Wang, Shuyi ; Lee, Fang-Hua ; Rando, Juliette ; Bonsignori, Mattia ; Hwang, Kwan-Ki ; Saunders, Kevin O ; Wiehe, Kevin ; Moody, M Anthony ; Hraber, Peter T ; Wagh, Kshitij ; Giorgi, Elena E ; Russell, Ronnie M ; Bibollet-Ruche, Frederic ; Liu, Weimin ; Connell, Jesse ; Smith, Andrew G ; DeVoto, Julia ; Murphy, Alexander I ; Smith, Jessica ; Ding, Wenge ; Zhao, Chengyan ; Chohan, Neha ; Okumura, Maho ; Rosario, Christina ; Ding, Yu ; Lindemuth, Emily ; Bauer, Anya M ; Bar, Katharine J ; Ambrozak, David ; Chao, Cara W ; Chuang, Gwo-Yu ; Geng, Hui ; Lin, Bob C ; Louder, Mark K ; Nguyen, Richard ; Zhang, Baoshan ; Lewis, Mark G ; Raymond, Donald D ; Doria-Rose, Nicole A ; Schramm, Chaim A ; Douek, Daniel C ; Roederer, Mario ; Kepler, Thomas B ; Kelsoe, Garnett ; Mascola, John R ; Kwong, Peter D ; Korber, Bette T ; Harrison, Stephen C ; Haynes, Barton F ; Hahn, Beatrice H ; Shaw, George M</creatorcontrib><description>Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S. Another rhesus antibody bound the CD4 binding site by CD4 mimicry, mirroring human bNAbs 8ANC131, CH235, and VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 1095-9203</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.abd2638</identifier><identifier>PMID: 33214287</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Amino acids ; Animals ; Antibodies ; Binding Sites ; Biological Coevolution - immunology ; Broadly Neutralizing Antibodies - chemistry ; Broadly Neutralizing Antibodies - genetics ; Broadly Neutralizing Antibodies - immunology ; CD4 Antigens - immunology ; Coevolution ; Cryoelectron Microscopy ; Design ; Epitopes ; Epitopes - immunology ; Evolution ; Glycoproteins ; HIV ; HIV Antibodies - chemistry ; HIV Antibodies - genetics ; HIV Antibodies - immunology ; HIV Envelope Protein gp120 - genetics ; HIV Envelope Protein gp120 - immunology ; HIV Infections - immunology ; HIV-1 - genetics ; HIV-1 - immunology ; Human immunodeficiency virus ; Humans ; Immunization ; Macaca mulatta ; Molecular Mimicry - immunology ; Neutralization ; Persistence ; Proteins ; Simian Immunodeficiency Virus - genetics ; Simian Immunodeficiency Virus - immunology ; Vaccine development ; Vaccines ; Virus Replication ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 2021-01, Vol.371 (6525)</ispartof><rights>Copyright © 2021, American Association for the Advancement of Science.</rights><rights>Copyright © 2021, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-703b00fd349b51e512a64d36681720d7e698695db009107777b536fdea88fb313</citedby><cites>FETCH-LOGICAL-c421t-703b00fd349b51e512a64d36681720d7e698695db009107777b536fdea88fb313</cites><orcidid>0000-0002-9773-0071 ; 0000-0002-2970-7259 ; 0000-0001-7123-4902 ; 0000-0002-9393-3074 ; 0000-0002-2920-4897 ; 0000-0001-9933-9618 ; 0000-0001-7215-9393 ; 0000-0003-2973-2101 ; 0000-0002-8770-040X ; 0000-0002-7643-9023 ; 0000-0001-7399-7954 ; 0000-0001-7448-7040 ; 0000-0001-6831-9323 ; 0000-0002-2338-4532 ; 0000-0002-2508-4226 ; 0000-0002-9400-9887 ; 0000-0003-3560-232X ; 0000-0001-7231-8219 ; 0000-0003-1484-4207 ; 0000-0002-3903-6997 ; 0000-0002-1742-9255 ; 0000-0002-3775-6560 ; 0000-0003-3866-960X ; 0000-0002-3890-5855 ; 0000-0002-5293-4695 ; 0000-0001-7552-6582 ; 0000-0002-1383-6865 ; 0000-0002-2026-5757 ; 0000-0001-7852-0135 ; 0000-0001-7540-9263 ; 0000-0001-5721-0787 ; 0000-0003-0586-103X ; 0000-0003-1521-2383 ; 0000-0002-9889-7076 ; 0000-0003-1853-1902 ; 0000-0003-2453-3461 ; 0000-0003-4154-6141 ; 0000-0002-5731-3054 ; 0000-0002-2665-4622</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2871,2872,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33214287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roark, Ryan S</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Williams, Wilton B</creatorcontrib><creatorcontrib>Chug, Hema</creatorcontrib><creatorcontrib>Mason, Rosemarie D</creatorcontrib><creatorcontrib>Gorman, Jason</creatorcontrib><creatorcontrib>Wang, Shuyi</creatorcontrib><creatorcontrib>Lee, Fang-Hua</creatorcontrib><creatorcontrib>Rando, Juliette</creatorcontrib><creatorcontrib>Bonsignori, Mattia</creatorcontrib><creatorcontrib>Hwang, Kwan-Ki</creatorcontrib><creatorcontrib>Saunders, Kevin O</creatorcontrib><creatorcontrib>Wiehe, Kevin</creatorcontrib><creatorcontrib>Moody, M Anthony</creatorcontrib><creatorcontrib>Hraber, Peter T</creatorcontrib><creatorcontrib>Wagh, Kshitij</creatorcontrib><creatorcontrib>Giorgi, Elena E</creatorcontrib><creatorcontrib>Russell, Ronnie M</creatorcontrib><creatorcontrib>Bibollet-Ruche, Frederic</creatorcontrib><creatorcontrib>Liu, Weimin</creatorcontrib><creatorcontrib>Connell, Jesse</creatorcontrib><creatorcontrib>Smith, Andrew G</creatorcontrib><creatorcontrib>DeVoto, Julia</creatorcontrib><creatorcontrib>Murphy, Alexander I</creatorcontrib><creatorcontrib>Smith, Jessica</creatorcontrib><creatorcontrib>Ding, Wenge</creatorcontrib><creatorcontrib>Zhao, Chengyan</creatorcontrib><creatorcontrib>Chohan, Neha</creatorcontrib><creatorcontrib>Okumura, Maho</creatorcontrib><creatorcontrib>Rosario, Christina</creatorcontrib><creatorcontrib>Ding, Yu</creatorcontrib><creatorcontrib>Lindemuth, Emily</creatorcontrib><creatorcontrib>Bauer, Anya M</creatorcontrib><creatorcontrib>Bar, Katharine J</creatorcontrib><creatorcontrib>Ambrozak, David</creatorcontrib><creatorcontrib>Chao, Cara W</creatorcontrib><creatorcontrib>Chuang, Gwo-Yu</creatorcontrib><creatorcontrib>Geng, Hui</creatorcontrib><creatorcontrib>Lin, Bob C</creatorcontrib><creatorcontrib>Louder, Mark K</creatorcontrib><creatorcontrib>Nguyen, Richard</creatorcontrib><creatorcontrib>Zhang, Baoshan</creatorcontrib><creatorcontrib>Lewis, Mark G</creatorcontrib><creatorcontrib>Raymond, Donald D</creatorcontrib><creatorcontrib>Doria-Rose, Nicole A</creatorcontrib><creatorcontrib>Schramm, Chaim A</creatorcontrib><creatorcontrib>Douek, Daniel C</creatorcontrib><creatorcontrib>Roederer, Mario</creatorcontrib><creatorcontrib>Kepler, Thomas B</creatorcontrib><creatorcontrib>Kelsoe, Garnett</creatorcontrib><creatorcontrib>Mascola, John R</creatorcontrib><creatorcontrib>Kwong, Peter D</creatorcontrib><creatorcontrib>Korber, Bette T</creatorcontrib><creatorcontrib>Harrison, Stephen C</creatorcontrib><creatorcontrib>Haynes, Barton F</creatorcontrib><creatorcontrib>Hahn, Beatrice H</creatorcontrib><creatorcontrib>Shaw, George M</creatorcontrib><title>Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S. Another rhesus antibody bound the CD4 binding site by CD4 mimicry, mirroring human bNAbs 8ANC131, CH235, and VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Binding Sites</subject><subject>Biological Coevolution - immunology</subject><subject>Broadly Neutralizing Antibodies - chemistry</subject><subject>Broadly Neutralizing Antibodies - genetics</subject><subject>Broadly Neutralizing Antibodies - immunology</subject><subject>CD4 Antigens - immunology</subject><subject>Coevolution</subject><subject>Cryoelectron Microscopy</subject><subject>Design</subject><subject>Epitopes</subject><subject>Epitopes - immunology</subject><subject>Evolution</subject><subject>Glycoproteins</subject><subject>HIV</subject><subject>HIV Antibodies - chemistry</subject><subject>HIV Antibodies - genetics</subject><subject>HIV Antibodies - immunology</subject><subject>HIV Envelope Protein gp120 - genetics</subject><subject>HIV Envelope Protein gp120 - immunology</subject><subject>HIV Infections - immunology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunization</subject><subject>Macaca mulatta</subject><subject>Molecular Mimicry - immunology</subject><subject>Neutralization</subject><subject>Persistence</subject><subject>Proteins</subject><subject>Simian Immunodeficiency Virus - genetics</subject><subject>Simian Immunodeficiency Virus - immunology</subject><subject>Vaccine development</subject><subject>Vaccines</subject><subject>Virus Replication</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1LAzEQxYMotn6cvcmCFy-rk2Q3m70IUqoWBEHUoyGbZDVlm9TNbqH-9aa2FnUuc3i_eczjIXSC4QJjwi6DssYpcyErTRjlO2iIoczTkgDdRUMAylIORT5AByFMAaJW0n00oJTgjPBiiF4fjZJz2_WN7Kx3ia-Tu8lLipOxW6TSdbbyepkobxa-6b8J65KZVPKjNyFpjNTWvSWdT5zpu1Y29nPtU7VR6t6P0F4tm2CON_sQPd-Mn0Z36f3D7WR0fZ-qjOAuLYBWALWmWVnl2OSYSJZpyhjHBQFdGFZyVuY6QiWGIk6VU1ZrIzmvK4rpIbpa-877ama0Mm71jJi3dibbpfDSir-Ks-_izS8EhwwKTqPB-cag9atonZjZoEzTSGd8HwTJGIUyDkT07B869X3rYrwVRbIikiRSl2tKtT6E1tTbZzCIVXdi053YdBcvTn9n2PI_ZdEv0aiX0A</recordid><startdate>20210108</startdate><enddate>20210108</enddate><creator>Roark, Ryan S</creator><creator>Li, Hui</creator><creator>Williams, Wilton B</creator><creator>Chug, Hema</creator><creator>Mason, Rosemarie D</creator><creator>Gorman, Jason</creator><creator>Wang, Shuyi</creator><creator>Lee, Fang-Hua</creator><creator>Rando, Juliette</creator><creator>Bonsignori, Mattia</creator><creator>Hwang, Kwan-Ki</creator><creator>Saunders, Kevin O</creator><creator>Wiehe, Kevin</creator><creator>Moody, M Anthony</creator><creator>Hraber, Peter T</creator><creator>Wagh, Kshitij</creator><creator>Giorgi, Elena E</creator><creator>Russell, Ronnie M</creator><creator>Bibollet-Ruche, Frederic</creator><creator>Liu, Weimin</creator><creator>Connell, Jesse</creator><creator>Smith, Andrew G</creator><creator>DeVoto, Julia</creator><creator>Murphy, Alexander I</creator><creator>Smith, Jessica</creator><creator>Ding, Wenge</creator><creator>Zhao, Chengyan</creator><creator>Chohan, Neha</creator><creator>Okumura, Maho</creator><creator>Rosario, Christina</creator><creator>Ding, Yu</creator><creator>Lindemuth, Emily</creator><creator>Bauer, Anya M</creator><creator>Bar, Katharine J</creator><creator>Ambrozak, David</creator><creator>Chao, Cara W</creator><creator>Chuang, Gwo-Yu</creator><creator>Geng, Hui</creator><creator>Lin, Bob C</creator><creator>Louder, Mark K</creator><creator>Nguyen, Richard</creator><creator>Zhang, Baoshan</creator><creator>Lewis, Mark G</creator><creator>Raymond, Donald D</creator><creator>Doria-Rose, Nicole A</creator><creator>Schramm, Chaim A</creator><creator>Douek, Daniel C</creator><creator>Roederer, Mario</creator><creator>Kepler, Thomas B</creator><creator>Kelsoe, Garnett</creator><creator>Mascola, John R</creator><creator>Kwong, Peter D</creator><creator>Korber, Bette T</creator><creator>Harrison, Stephen C</creator><creator>Haynes, Barton F</creator><creator>Hahn, Beatrice H</creator><creator>Shaw, George M</creator><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9773-0071</orcidid><orcidid>https://orcid.org/0000-0002-2970-7259</orcidid><orcidid>https://orcid.org/0000-0001-7123-4902</orcidid><orcidid>https://orcid.org/0000-0002-9393-3074</orcidid><orcidid>https://orcid.org/0000-0002-2920-4897</orcidid><orcidid>https://orcid.org/0000-0001-9933-9618</orcidid><orcidid>https://orcid.org/0000-0001-7215-9393</orcidid><orcidid>https://orcid.org/0000-0003-2973-2101</orcidid><orcidid>https://orcid.org/0000-0002-8770-040X</orcidid><orcidid>https://orcid.org/0000-0002-7643-9023</orcidid><orcidid>https://orcid.org/0000-0001-7399-7954</orcidid><orcidid>https://orcid.org/0000-0001-7448-7040</orcidid><orcidid>https://orcid.org/0000-0001-6831-9323</orcidid><orcidid>https://orcid.org/0000-0002-2338-4532</orcidid><orcidid>https://orcid.org/0000-0002-2508-4226</orcidid><orcidid>https://orcid.org/0000-0002-9400-9887</orcidid><orcidid>https://orcid.org/0000-0003-3560-232X</orcidid><orcidid>https://orcid.org/0000-0001-7231-8219</orcidid><orcidid>https://orcid.org/0000-0003-1484-4207</orcidid><orcidid>https://orcid.org/0000-0002-3903-6997</orcidid><orcidid>https://orcid.org/0000-0002-1742-9255</orcidid><orcidid>https://orcid.org/0000-0002-3775-6560</orcidid><orcidid>https://orcid.org/0000-0003-3866-960X</orcidid><orcidid>https://orcid.org/0000-0002-3890-5855</orcidid><orcidid>https://orcid.org/0000-0002-5293-4695</orcidid><orcidid>https://orcid.org/0000-0001-7552-6582</orcidid><orcidid>https://orcid.org/0000-0002-1383-6865</orcidid><orcidid>https://orcid.org/0000-0002-2026-5757</orcidid><orcidid>https://orcid.org/0000-0001-7852-0135</orcidid><orcidid>https://orcid.org/0000-0001-7540-9263</orcidid><orcidid>https://orcid.org/0000-0001-5721-0787</orcidid><orcidid>https://orcid.org/0000-0003-0586-103X</orcidid><orcidid>https://orcid.org/0000-0003-1521-2383</orcidid><orcidid>https://orcid.org/0000-0002-9889-7076</orcidid><orcidid>https://orcid.org/0000-0003-1853-1902</orcidid><orcidid>https://orcid.org/0000-0003-2453-3461</orcidid><orcidid>https://orcid.org/0000-0003-4154-6141</orcidid><orcidid>https://orcid.org/0000-0002-5731-3054</orcidid><orcidid>https://orcid.org/0000-0002-2665-4622</orcidid></search><sort><creationdate>20210108</creationdate><title>Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth</title><author>Roark, Ryan S ; Li, Hui ; Williams, Wilton B ; Chug, Hema ; Mason, Rosemarie D ; Gorman, Jason ; Wang, Shuyi ; Lee, Fang-Hua ; Rando, Juliette ; Bonsignori, Mattia ; Hwang, Kwan-Ki ; Saunders, Kevin O ; Wiehe, Kevin ; Moody, M Anthony ; Hraber, Peter T ; Wagh, Kshitij ; Giorgi, Elena E ; Russell, Ronnie M ; Bibollet-Ruche, Frederic ; Liu, Weimin ; Connell, Jesse ; Smith, Andrew G ; DeVoto, Julia ; Murphy, Alexander I ; Smith, Jessica ; Ding, Wenge ; Zhao, Chengyan ; Chohan, Neha ; Okumura, Maho ; Rosario, Christina ; Ding, Yu ; Lindemuth, Emily ; Bauer, Anya M ; Bar, Katharine J ; Ambrozak, David ; Chao, Cara W ; Chuang, Gwo-Yu ; Geng, Hui ; Lin, Bob C ; Louder, Mark K ; Nguyen, Richard ; Zhang, Baoshan ; Lewis, Mark G ; Raymond, Donald D ; Doria-Rose, Nicole A ; Schramm, Chaim A ; Douek, Daniel C ; Roederer, Mario ; Kepler, Thomas B ; Kelsoe, Garnett ; Mascola, John R ; Kwong, Peter D ; Korber, Bette T ; Harrison, Stephen C ; Haynes, Barton F ; Hahn, Beatrice H ; Shaw, George M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-703b00fd349b51e512a64d36681720d7e698695db009107777b536fdea88fb313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Binding Sites</topic><topic>Biological Coevolution - immunology</topic><topic>Broadly Neutralizing Antibodies - chemistry</topic><topic>Broadly Neutralizing Antibodies - genetics</topic><topic>Broadly Neutralizing Antibodies - immunology</topic><topic>CD4 Antigens - immunology</topic><topic>Coevolution</topic><topic>Cryoelectron Microscopy</topic><topic>Design</topic><topic>Epitopes</topic><topic>Epitopes - immunology</topic><topic>Evolution</topic><topic>Glycoproteins</topic><topic>HIV</topic><topic>HIV Antibodies - chemistry</topic><topic>HIV Antibodies - genetics</topic><topic>HIV Antibodies - immunology</topic><topic>HIV Envelope Protein gp120 - genetics</topic><topic>HIV Envelope Protein gp120 - immunology</topic><topic>HIV Infections - immunology</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunization</topic><topic>Macaca mulatta</topic><topic>Molecular Mimicry - immunology</topic><topic>Neutralization</topic><topic>Persistence</topic><topic>Proteins</topic><topic>Simian Immunodeficiency Virus - genetics</topic><topic>Simian Immunodeficiency Virus - immunology</topic><topic>Vaccine development</topic><topic>Vaccines</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roark, Ryan S</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Williams, Wilton B</creatorcontrib><creatorcontrib>Chug, Hema</creatorcontrib><creatorcontrib>Mason, Rosemarie D</creatorcontrib><creatorcontrib>Gorman, Jason</creatorcontrib><creatorcontrib>Wang, Shuyi</creatorcontrib><creatorcontrib>Lee, Fang-Hua</creatorcontrib><creatorcontrib>Rando, Juliette</creatorcontrib><creatorcontrib>Bonsignori, Mattia</creatorcontrib><creatorcontrib>Hwang, Kwan-Ki</creatorcontrib><creatorcontrib>Saunders, Kevin O</creatorcontrib><creatorcontrib>Wiehe, Kevin</creatorcontrib><creatorcontrib>Moody, M Anthony</creatorcontrib><creatorcontrib>Hraber, Peter T</creatorcontrib><creatorcontrib>Wagh, Kshitij</creatorcontrib><creatorcontrib>Giorgi, Elena E</creatorcontrib><creatorcontrib>Russell, Ronnie M</creatorcontrib><creatorcontrib>Bibollet-Ruche, Frederic</creatorcontrib><creatorcontrib>Liu, Weimin</creatorcontrib><creatorcontrib>Connell, Jesse</creatorcontrib><creatorcontrib>Smith, Andrew G</creatorcontrib><creatorcontrib>DeVoto, Julia</creatorcontrib><creatorcontrib>Murphy, Alexander I</creatorcontrib><creatorcontrib>Smith, Jessica</creatorcontrib><creatorcontrib>Ding, Wenge</creatorcontrib><creatorcontrib>Zhao, Chengyan</creatorcontrib><creatorcontrib>Chohan, Neha</creatorcontrib><creatorcontrib>Okumura, Maho</creatorcontrib><creatorcontrib>Rosario, Christina</creatorcontrib><creatorcontrib>Ding, Yu</creatorcontrib><creatorcontrib>Lindemuth, Emily</creatorcontrib><creatorcontrib>Bauer, Anya M</creatorcontrib><creatorcontrib>Bar, Katharine J</creatorcontrib><creatorcontrib>Ambrozak, David</creatorcontrib><creatorcontrib>Chao, Cara W</creatorcontrib><creatorcontrib>Chuang, Gwo-Yu</creatorcontrib><creatorcontrib>Geng, Hui</creatorcontrib><creatorcontrib>Lin, Bob C</creatorcontrib><creatorcontrib>Louder, Mark K</creatorcontrib><creatorcontrib>Nguyen, Richard</creatorcontrib><creatorcontrib>Zhang, Baoshan</creatorcontrib><creatorcontrib>Lewis, Mark G</creatorcontrib><creatorcontrib>Raymond, Donald D</creatorcontrib><creatorcontrib>Doria-Rose, Nicole A</creatorcontrib><creatorcontrib>Schramm, Chaim A</creatorcontrib><creatorcontrib>Douek, Daniel C</creatorcontrib><creatorcontrib>Roederer, Mario</creatorcontrib><creatorcontrib>Kepler, Thomas B</creatorcontrib><creatorcontrib>Kelsoe, Garnett</creatorcontrib><creatorcontrib>Mascola, John R</creatorcontrib><creatorcontrib>Kwong, Peter D</creatorcontrib><creatorcontrib>Korber, Bette T</creatorcontrib><creatorcontrib>Harrison, Stephen C</creatorcontrib><creatorcontrib>Haynes, Barton F</creatorcontrib><creatorcontrib>Hahn, Beatrice H</creatorcontrib><creatorcontrib>Shaw, George M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roark, Ryan S</au><au>Li, Hui</au><au>Williams, Wilton B</au><au>Chug, Hema</au><au>Mason, Rosemarie D</au><au>Gorman, Jason</au><au>Wang, Shuyi</au><au>Lee, Fang-Hua</au><au>Rando, Juliette</au><au>Bonsignori, Mattia</au><au>Hwang, Kwan-Ki</au><au>Saunders, Kevin O</au><au>Wiehe, Kevin</au><au>Moody, M Anthony</au><au>Hraber, Peter T</au><au>Wagh, Kshitij</au><au>Giorgi, Elena E</au><au>Russell, Ronnie M</au><au>Bibollet-Ruche, Frederic</au><au>Liu, Weimin</au><au>Connell, Jesse</au><au>Smith, Andrew G</au><au>DeVoto, Julia</au><au>Murphy, Alexander I</au><au>Smith, Jessica</au><au>Ding, Wenge</au><au>Zhao, Chengyan</au><au>Chohan, Neha</au><au>Okumura, Maho</au><au>Rosario, Christina</au><au>Ding, Yu</au><au>Lindemuth, Emily</au><au>Bauer, Anya M</au><au>Bar, Katharine J</au><au>Ambrozak, David</au><au>Chao, Cara W</au><au>Chuang, Gwo-Yu</au><au>Geng, Hui</au><au>Lin, Bob C</au><au>Louder, Mark K</au><au>Nguyen, Richard</au><au>Zhang, Baoshan</au><au>Lewis, Mark G</au><au>Raymond, Donald D</au><au>Doria-Rose, Nicole A</au><au>Schramm, Chaim A</au><au>Douek, Daniel C</au><au>Roederer, Mario</au><au>Kepler, Thomas B</au><au>Kelsoe, Garnett</au><au>Mascola, John R</au><au>Kwong, Peter D</au><au>Korber, Bette T</au><au>Harrison, Stephen C</au><au>Haynes, Barton F</au><au>Hahn, Beatrice H</au><au>Shaw, George M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2021-01-08</date><risdate>2021</risdate><volume>371</volume><issue>6525</issue><issn>0036-8075</issn><issn>1095-9203</issn><eissn>1095-9203</eissn><abstract>Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S. Another rhesus antibody bound the CD4 binding site by CD4 mimicry, mirroring human bNAbs 8ANC131, CH235, and VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>33214287</pmid><doi>10.1126/science.abd2638</doi><orcidid>https://orcid.org/0000-0002-9773-0071</orcidid><orcidid>https://orcid.org/0000-0002-2970-7259</orcidid><orcidid>https://orcid.org/0000-0001-7123-4902</orcidid><orcidid>https://orcid.org/0000-0002-9393-3074</orcidid><orcidid>https://orcid.org/0000-0002-2920-4897</orcidid><orcidid>https://orcid.org/0000-0001-9933-9618</orcidid><orcidid>https://orcid.org/0000-0001-7215-9393</orcidid><orcidid>https://orcid.org/0000-0003-2973-2101</orcidid><orcidid>https://orcid.org/0000-0002-8770-040X</orcidid><orcidid>https://orcid.org/0000-0002-7643-9023</orcidid><orcidid>https://orcid.org/0000-0001-7399-7954</orcidid><orcidid>https://orcid.org/0000-0001-7448-7040</orcidid><orcidid>https://orcid.org/0000-0001-6831-9323</orcidid><orcidid>https://orcid.org/0000-0002-2338-4532</orcidid><orcidid>https://orcid.org/0000-0002-2508-4226</orcidid><orcidid>https://orcid.org/0000-0002-9400-9887</orcidid><orcidid>https://orcid.org/0000-0003-3560-232X</orcidid><orcidid>https://orcid.org/0000-0001-7231-8219</orcidid><orcidid>https://orcid.org/0000-0003-1484-4207</orcidid><orcidid>https://orcid.org/0000-0002-3903-6997</orcidid><orcidid>https://orcid.org/0000-0002-1742-9255</orcidid><orcidid>https://orcid.org/0000-0002-3775-6560</orcidid><orcidid>https://orcid.org/0000-0003-3866-960X</orcidid><orcidid>https://orcid.org/0000-0002-3890-5855</orcidid><orcidid>https://orcid.org/0000-0002-5293-4695</orcidid><orcidid>https://orcid.org/0000-0001-7552-6582</orcidid><orcidid>https://orcid.org/0000-0002-1383-6865</orcidid><orcidid>https://orcid.org/0000-0002-2026-5757</orcidid><orcidid>https://orcid.org/0000-0001-7852-0135</orcidid><orcidid>https://orcid.org/0000-0001-7540-9263</orcidid><orcidid>https://orcid.org/0000-0001-5721-0787</orcidid><orcidid>https://orcid.org/0000-0003-0586-103X</orcidid><orcidid>https://orcid.org/0000-0003-1521-2383</orcidid><orcidid>https://orcid.org/0000-0002-9889-7076</orcidid><orcidid>https://orcid.org/0000-0003-1853-1902</orcidid><orcidid>https://orcid.org/0000-0003-2453-3461</orcidid><orcidid>https://orcid.org/0000-0003-4154-6141</orcidid><orcidid>https://orcid.org/0000-0002-5731-3054</orcidid><orcidid>https://orcid.org/0000-0002-2665-4622</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2021-01, Vol.371 (6525) |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8040783 |
| source | American Association for the Advancement of Science; MEDLINE |
| subjects | Amino acids Animals Antibodies Binding Sites Biological Coevolution - immunology Broadly Neutralizing Antibodies - chemistry Broadly Neutralizing Antibodies - genetics Broadly Neutralizing Antibodies - immunology CD4 Antigens - immunology Coevolution Cryoelectron Microscopy Design Epitopes Epitopes - immunology Evolution Glycoproteins HIV HIV Antibodies - chemistry HIV Antibodies - genetics HIV Antibodies - immunology HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Infections - immunology HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus Humans Immunization Macaca mulatta Molecular Mimicry - immunology Neutralization Persistence Proteins Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - immunology Vaccine development Vaccines Virus Replication Viruses |
| title | Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A14%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recapitulation%20of%20HIV-1%20Env-antibody%20coevolution%20in%20macaques%20leading%20to%20neutralization%20breadth&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Roark,%20Ryan%20S&rft.date=2021-01-08&rft.volume=371&rft.issue=6525&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.abd2638&rft_dat=%3Cproquest_pubme%3E2463099990%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2462476302&rft_id=info:pmid/33214287&rfr_iscdi=true |