Semisynthetic Derivatives of the Verticillin Class of Natural Products through Acylation of the C11 Hydroxy Group

The verticillins, a class of epipolythiodioxopiperazine alkaloids (ETPs) first described 50 years ago with the discovery of verticillin A (1), have gained attention due to their potent activity against cancer cells, noted both in vitro and in vivo. In this study, the complex scaffold afforded throug...

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Veröffentlicht in:	ACS medicinal chemistry letters 2021-04, Vol.12 (4), p.625-630
Hauptverfasser:	Amrine, Chiraz Soumia M, Huntsman, Andrew C, Doyle, Michael G, Burdette, Joanna E, Pearce, Cedric J, Fuchs, James R, Oberlies, Nicholas H
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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