Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis

Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To determine how co-transcriptional splicing is integrated with transcription elongation and 3′ end formation in mammalian cells, we performed long-read sequencing of individual nascent RNAs and precision run-on...

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Veröffentlicht in:	Molecular cell 2021-03, Vol.81 (5), p.998-1012.e7
Hauptverfasser:	Reimer, Kirsten A., Mimoso, Claudia A., Adelman, Karen, Neugebauer, Karla M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence beta-Globins - deficiency beta-Globins - genetics beta-Thalassemia - genetics beta-Thalassemia - metabolism beta-Thalassemia - pathology Cell Differentiation Cell Line, Tumor co-transcriptional splicing Erythroid Cells - cytology Erythroid Cells - metabolism erythropoiesis Erythropoiesis - genetics Exons globin Humans Introns Leukocytes - cytology Leukocytes - metabolism long-read sequencing Mice Mutation nascent RNA PacBio RNA Cleavage RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA Splice Sites RNA Splicing Spliceosomes - genetics Spliceosomes - metabolism Transcription Elongation, Genetic
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