Clinical Validation of the Comprehensive Complication Index in Colon Cancer Surgery
(1) Introduction: To date, the sensitivity of the Comprehensive Complication Index (CCI) in a homogeneous cohort of colonic resections for oncologic purposes has not been reported. The present study aims to compare the CCI with the conventional Clavien-Dindo classification (CDC) in colon cancer pati...
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| Veröffentlicht in: | Cancers 2021-04, Vol.13 (7), p.1745 |
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| creator | Tamini, Nicolò Bernasconi, Davide Ripamonti, Lorenzo Lo Bianco, Giulia Braga, Marco Nespoli, Luca |
| description | (1) Introduction: To date, the sensitivity of the Comprehensive Complication Index (CCI) in a homogeneous cohort of colonic resections for oncologic purposes has not been reported. The present study aims to compare the CCI with the conventional Clavien-Dindo classification (CDC) in colon cancer patients. (2) Methods: The clinical data of patients submitted to an elective colectomy for adenocarcinoma were retrieved from a prospectively maintained database. Postoperative complications and length of stay were reviewed, and CDC and CCI scores were calculated for each patient. The association of the CCI and the CDC with the length of stay, prolongation of stay and readmission rate were assessed and compared. (3) Results: The overall postoperative morbidity was 26.9%. In particular, 157 (20.4%) patients had more than one complication. A strong correlation between the two scoring systems was observed (r = 99.4%; 95%CI: 99.3-99.5%). In multivariate analysis, CCI had a higher predictive ability for all endpoints. Regarding subgroup analysis, the difference between the CCI and CDC was progressively increased when evaluating outcome measures in complicated and multi-complicated patients. (4) Conclusion: Both scoring systems adequately report the overall burden of postoperative complications. The CCI showed a greater ability than the CDC to predict hospital stay, particularly in patients with multiple postoperative complications. |
| doi_str_mv | 10.3390/cancers13071745 |
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The present study aims to compare the CCI with the conventional Clavien-Dindo classification (CDC) in colon cancer patients. (2) Methods: The clinical data of patients submitted to an elective colectomy for adenocarcinoma were retrieved from a prospectively maintained database. Postoperative complications and length of stay were reviewed, and CDC and CCI scores were calculated for each patient. The association of the CCI and the CDC with the length of stay, prolongation of stay and readmission rate were assessed and compared. (3) Results: The overall postoperative morbidity was 26.9%. In particular, 157 (20.4%) patients had more than one complication. A strong correlation between the two scoring systems was observed (r = 99.4%; 95%CI: 99.3-99.5%). In multivariate analysis, CCI had a higher predictive ability for all endpoints. Regarding subgroup analysis, the difference between the CCI and CDC was progressively increased when evaluating outcome measures in complicated and multi-complicated patients. (4) Conclusion: Both scoring systems adequately report the overall burden of postoperative complications. The CCI showed a greater ability than the CDC to predict hospital stay, particularly in patients with multiple postoperative complications.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13071745</identifier><identifier>PMID: 33917529</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenocarcinoma ; Cancer surgery ; Classification ; Colon cancer ; Colorectal cancer ; Colorectal surgery ; Comorbidity ; Disease prevention ; Length of stay ; Morbidity ; Multivariate analysis ; Patients ; Recovery (Medical) ; Surgery ; Surgical outcomes</subject><ispartof>Cancers, 2021-04, Vol.13 (7), p.1745</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-45a9a20cdd90e255256ba3c3e66bb621d6a8efa0b1c76a91279f416a5d0237dc3</citedby><cites>FETCH-LOGICAL-c421t-45a9a20cdd90e255256ba3c3e66bb621d6a8efa0b1c76a91279f416a5d0237dc3</cites><orcidid>0000-0002-4945-5677 ; 0000-0001-8771-5428 ; 0000-0003-3917-6831 ; 0000-0002-3762-4285</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038800/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038800/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33917529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamini, Nicolò</creatorcontrib><creatorcontrib>Bernasconi, Davide</creatorcontrib><creatorcontrib>Ripamonti, Lorenzo</creatorcontrib><creatorcontrib>Lo Bianco, Giulia</creatorcontrib><creatorcontrib>Braga, Marco</creatorcontrib><creatorcontrib>Nespoli, Luca</creatorcontrib><title>Clinical Validation of the Comprehensive Complication Index in Colon Cancer Surgery</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>(1) Introduction: To date, the sensitivity of the Comprehensive Complication Index (CCI) in a homogeneous cohort of colonic resections for oncologic purposes has not been reported. The present study aims to compare the CCI with the conventional Clavien-Dindo classification (CDC) in colon cancer patients. (2) Methods: The clinical data of patients submitted to an elective colectomy for adenocarcinoma were retrieved from a prospectively maintained database. Postoperative complications and length of stay were reviewed, and CDC and CCI scores were calculated for each patient. The association of the CCI and the CDC with the length of stay, prolongation of stay and readmission rate were assessed and compared. (3) Results: The overall postoperative morbidity was 26.9%. In particular, 157 (20.4%) patients had more than one complication. A strong correlation between the two scoring systems was observed (r = 99.4%; 95%CI: 99.3-99.5%). In multivariate analysis, CCI had a higher predictive ability for all endpoints. Regarding subgroup analysis, the difference between the CCI and CDC was progressively increased when evaluating outcome measures in complicated and multi-complicated patients. (4) Conclusion: Both scoring systems adequately report the overall burden of postoperative complications. The CCI showed a greater ability than the CDC to predict hospital stay, particularly in patients with multiple postoperative complications.</description><subject>Adenocarcinoma</subject><subject>Cancer surgery</subject><subject>Classification</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal surgery</subject><subject>Comorbidity</subject><subject>Disease prevention</subject><subject>Length of stay</subject><subject>Morbidity</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Recovery (Medical)</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1LAzEQhoMottSevcmCFy-1-dhNdi-CLH4UCh6qXkM2m21T0qQmu6L_3tjWUjuXzCTPO8zkBeASwVtCCjiWwkrlAyKQIZZmJ6CPIcMjSov09CDvgWEISxiDEMQoOwe9KEcsw0UfzEqjrZbCJO_C6Fq02tnENUm7UEnpVmuvFsoG_bmtTCQ3xMTW6ivRNt6aWJabSZJZ5-fKf1-As0aYoIa7cwDeHh9ey-fR9OVpUt5PRzLFqB2lmSgEhrKuC6hwluGMVoJIoiitKopRTUWuGgErJBkVBcKsaFJERVZDTFgtyQDcbfuuu2qlaqls64Xha69Xwn9zJzT__2L1gs_dJ88hyfP4HQNws2vg3UenQstXOkhljLDKdYHjDMOckjTNI3p9hC5d521cL1Ipo5DltIjUeEtJ70LwqtkPgyD_9YwfeRYVV4c77Pk_h8gPbl-UBg</recordid><startdate>20210406</startdate><enddate>20210406</enddate><creator>Tamini, Nicolò</creator><creator>Bernasconi, Davide</creator><creator>Ripamonti, Lorenzo</creator><creator>Lo Bianco, Giulia</creator><creator>Braga, Marco</creator><creator>Nespoli, Luca</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4945-5677</orcidid><orcidid>https://orcid.org/0000-0001-8771-5428</orcidid><orcidid>https://orcid.org/0000-0003-3917-6831</orcidid><orcidid>https://orcid.org/0000-0002-3762-4285</orcidid></search><sort><creationdate>20210406</creationdate><title>Clinical Validation of the Comprehensive Complication Index in Colon Cancer Surgery</title><author>Tamini, Nicolò ; Bernasconi, Davide ; Ripamonti, Lorenzo ; Lo Bianco, Giulia ; Braga, Marco ; Nespoli, Luca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-45a9a20cdd90e255256ba3c3e66bb621d6a8efa0b1c76a91279f416a5d0237dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenocarcinoma</topic><topic>Cancer surgery</topic><topic>Classification</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal surgery</topic><topic>Comorbidity</topic><topic>Disease prevention</topic><topic>Length of stay</topic><topic>Morbidity</topic><topic>Multivariate analysis</topic><topic>Patients</topic><topic>Recovery (Medical)</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamini, Nicolò</creatorcontrib><creatorcontrib>Bernasconi, Davide</creatorcontrib><creatorcontrib>Ripamonti, Lorenzo</creatorcontrib><creatorcontrib>Lo Bianco, Giulia</creatorcontrib><creatorcontrib>Braga, Marco</creatorcontrib><creatorcontrib>Nespoli, Luca</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamini, Nicolò</au><au>Bernasconi, Davide</au><au>Ripamonti, Lorenzo</au><au>Lo Bianco, Giulia</au><au>Braga, Marco</au><au>Nespoli, Luca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Validation of the Comprehensive Complication Index in Colon Cancer Surgery</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2021-04-06</date><risdate>2021</risdate><volume>13</volume><issue>7</issue><spage>1745</spage><pages>1745-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>(1) Introduction: To date, the sensitivity of the Comprehensive Complication Index (CCI) in a homogeneous cohort of colonic resections for oncologic purposes has not been reported. The present study aims to compare the CCI with the conventional Clavien-Dindo classification (CDC) in colon cancer patients. (2) Methods: The clinical data of patients submitted to an elective colectomy for adenocarcinoma were retrieved from a prospectively maintained database. Postoperative complications and length of stay were reviewed, and CDC and CCI scores were calculated for each patient. The association of the CCI and the CDC with the length of stay, prolongation of stay and readmission rate were assessed and compared. (3) Results: The overall postoperative morbidity was 26.9%. In particular, 157 (20.4%) patients had more than one complication. A strong correlation between the two scoring systems was observed (r = 99.4%; 95%CI: 99.3-99.5%). In multivariate analysis, CCI had a higher predictive ability for all endpoints. Regarding subgroup analysis, the difference between the CCI and CDC was progressively increased when evaluating outcome measures in complicated and multi-complicated patients. (4) Conclusion: Both scoring systems adequately report the overall burden of postoperative complications. The CCI showed a greater ability than the CDC to predict hospital stay, particularly in patients with multiple postoperative complications.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33917529</pmid><doi>10.3390/cancers13071745</doi><orcidid>https://orcid.org/0000-0002-4945-5677</orcidid><orcidid>https://orcid.org/0000-0001-8771-5428</orcidid><orcidid>https://orcid.org/0000-0003-3917-6831</orcidid><orcidid>https://orcid.org/0000-0002-3762-4285</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Cancer surgery Classification Colon cancer Colorectal cancer Colorectal surgery Comorbidity Disease prevention Length of stay Morbidity Multivariate analysis Patients Recovery (Medical) Surgery Surgical outcomes |
| title | Clinical Validation of the Comprehensive Complication Index in Colon Cancer Surgery |
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