Detection of Microsatellite Instability: State of the Art and Future Applications in Circulating Tumour DNA (ctDNA)

Microsatellite instability (MSI) is a molecular scar resulting from a defective mismatch repair system (dMMR) and associated with various malignancies. MSI tumours are characterized by the accumulation of mutations throughout the genome and particularly clustered in highly repetitive microsatellite...

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Veröffentlicht in:	Cancers 2021-03, Vol.13 (7), p.1491
Hauptverfasser:	Gilson, Pauline, Merlin, Jean-Louis, Harlé, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Cancer Chemotherapy Decision making Deoxyribonucleic acid DNA Endometrial cancer Epigenetics FDA approval Genes Genomes Immunohistochemistry Life Sciences Metastasis Microsatellite instability Mismatch repair Mutation Next-generation sequencing Nucleotide sequence Polymerase chain reaction Prognosis Review Risk assessment Solid tumors Tumors
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