Remodeling of Cancer-Specific Metabolism under Hypoxia with Lactate Calcium Salt in Human Colorectal Cancer Cells

Hypoxic cancer cells meet their growing energy requirements by upregulating glycolysis, resulting in increased glucose consumption and lactate production. Herein, we used a unique approach to change in anaerobic glycolysis of cancer cells by lactate calcium salt (CaLac). Human colorectal cancer (CRC...

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Veröffentlicht in:	Cancers 2021-03, Vol.13 (7), p.1518
Hauptverfasser:	Jeong, Keun-Yeong, Sim, Jae-Jun, Park, Min Hee, Kim, Hwan Mook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antibodies Antitumor activity Calcium (intracellular) Calcium influx Cancer Cell culture Cell migration Colorectal cancer Colorectal carcinoma Dehydrogenases Energy requirements Enzymes Glucose Glycolysis Hypoxia Hypoxia-inducible factor 1a Intermediates Intracellular Ketoglutaric acid Kinases L-Lactate dehydrogenase Laboratories Lactic acid Metabolism Metabolites Metastases Polymerase chain reaction Proteins Pyruvic acid Supplements Transcription activation Tricarboxylic acid cycle Tumor microenvironment Vascular endothelial growth factor Wound healing Xenografts
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