Risk of Liver Fibrosis According to TSH Levels in Euthyroid Subjects
Alterations in thyroid function may contribute to the development of liver fibrosis especially in subjects with non-alcoholic fatty liver disease. This study aimed to investigate the risk of liver fibrosis according to low-normal thyroid function in the general population. We performed a descriptive...
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| Veröffentlicht in: | Journal of clinical medicine 2021-03, Vol.10 (7), p.1350 |
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| creator | Martínez-Escudé, Alba Pera, Guillem Rodríguez, Lluís Arteaga, Ingrid Expósito-Martínez, Carmen Torán-Monserrat, Pere Caballería, Llorenç |
| description | Alterations in thyroid function may contribute to the development of liver fibrosis especially in subjects with non-alcoholic fatty liver disease. This study aimed to investigate the risk of liver fibrosis according to low-normal thyroid function in the general population. We performed a descriptive cross-sectional study in subjects from 18-75 years randomly selected from 16 primary health care centers from 2017-2019. Each subject underwent clinical evaluation, physical examination, blood analysis and transient hepatic elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with fibrosis. We included 1096 subjects (60 ± 11 years; 61% women); 70% had strict-normal thyroid function and 30% had low-normal thyroid function. Low-normal thyroid function was associated with a higher liver stiffness (LS) values: 5.2 vs. 4.8 kPa (
= 0.001) and a greater prevalence of fibrosis: 6.1 vs. 3% (
= 0.016) and 4.3 vs. 2.1% (
= 0.044) for the cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively. After adjustment for potential confounding factors, the risk of fibrosis in subjects with low-normal thyroid function was OR 1.54 (
= 0.213). In conclusion, low-normal thyroid function is associated with higher LS values and a greater risk of liver fibrosis in the general population, being dependent on other metabolic factors. |
| doi_str_mv | 10.3390/jcm10071350 |
| format | Article |
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= 0.001) and a greater prevalence of fibrosis: 6.1 vs. 3% (
= 0.016) and 4.3 vs. 2.1% (
= 0.044) for the cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively. After adjustment for potential confounding factors, the risk of fibrosis in subjects with low-normal thyroid function was OR 1.54 (
= 0.213). In conclusion, low-normal thyroid function is associated with higher LS values and a greater risk of liver fibrosis in the general population, being dependent on other metabolic factors.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10071350</identifier><identifier>PMID: 33805893</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Alcohol use ; Blood platelets ; Blood pressure ; Body mass index ; Clinical medicine ; Diabetes ; High density lipoprotein ; Hypothyroidism ; Laboratories ; Liver diseases ; Normal distribution ; Obesity ; Population ; Serology ; Thyroid gland ; Variables ; Womens health</subject><ispartof>Journal of clinical medicine, 2021-03, Vol.10 (7), p.1350</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-5dac99f2f6c3c3f75c82894a7f77ee662f40895e8c92a87a82df35586c0310a73</citedby><cites>FETCH-LOGICAL-c409t-5dac99f2f6c3c3f75c82894a7f77ee662f40895e8c92a87a82df35586c0310a73</cites><orcidid>0000-0002-9865-7427 ; 0000-0003-0667-1609 ; 0000-0002-7990-0719</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037170/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037170/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33805893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martínez-Escudé, Alba</creatorcontrib><creatorcontrib>Pera, Guillem</creatorcontrib><creatorcontrib>Rodríguez, Lluís</creatorcontrib><creatorcontrib>Arteaga, Ingrid</creatorcontrib><creatorcontrib>Expósito-Martínez, Carmen</creatorcontrib><creatorcontrib>Torán-Monserrat, Pere</creatorcontrib><creatorcontrib>Caballería, Llorenç</creatorcontrib><title>Risk of Liver Fibrosis According to TSH Levels in Euthyroid Subjects</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Alterations in thyroid function may contribute to the development of liver fibrosis especially in subjects with non-alcoholic fatty liver disease. This study aimed to investigate the risk of liver fibrosis according to low-normal thyroid function in the general population. We performed a descriptive cross-sectional study in subjects from 18-75 years randomly selected from 16 primary health care centers from 2017-2019. Each subject underwent clinical evaluation, physical examination, blood analysis and transient hepatic elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with fibrosis. We included 1096 subjects (60 ± 11 years; 61% women); 70% had strict-normal thyroid function and 30% had low-normal thyroid function. Low-normal thyroid function was associated with a higher liver stiffness (LS) values: 5.2 vs. 4.8 kPa (
= 0.001) and a greater prevalence of fibrosis: 6.1 vs. 3% (
= 0.016) and 4.3 vs. 2.1% (
= 0.044) for the cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively. After adjustment for potential confounding factors, the risk of fibrosis in subjects with low-normal thyroid function was OR 1.54 (
= 0.213). In conclusion, low-normal thyroid function is associated with higher LS values and a greater risk of liver fibrosis in the general population, being dependent on other metabolic factors.</description><subject>Age</subject><subject>Alcohol use</subject><subject>Blood platelets</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Clinical medicine</subject><subject>Diabetes</subject><subject>High density lipoprotein</subject><subject>Hypothyroidism</subject><subject>Laboratories</subject><subject>Liver diseases</subject><subject>Normal distribution</subject><subject>Obesity</subject><subject>Population</subject><subject>Serology</subject><subject>Thyroid gland</subject><subject>Variables</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1LAzEQxYMoKrUn7xLwIkh1NtlskosgtVWhIPhxDmk2sanbTU12C_3v3VKV6lxmYH483sxD6DSDK0olXM_NIgPgGWWwh44JcD4AKuj-znyE-inNoSshcpLxQ3REqQAmJD1Gd88-feDg8MSvbMRjP40h-YRvjQmx9PU7bgJ-fXnAE7uyVcK-xqO2ma1j8CV-aadza5p0gg6crpLtf_ceehuPXocPg8nT_ePwdjIwOchmwEptpHTEFYYa6jgzggiZa-44t7YoiMtBSGaFkUQLrgUpHWVMFAZoBprTHrrZ6i7b6cKWxtZN1JVaRr_Qca2C9urvpvYz9R5WSgDlGYdO4OJbIIbP1qZGLXwytqp0bUObFGEgWGcESIee_0PnoY11d54iRZ4BlUxsBC-3lOnelqJ1v2YyUJuA1E5AHX226_-X_YmDfgHc9on1</recordid><startdate>20210325</startdate><enddate>20210325</enddate><creator>Martínez-Escudé, Alba</creator><creator>Pera, Guillem</creator><creator>Rodríguez, Lluís</creator><creator>Arteaga, Ingrid</creator><creator>Expósito-Martínez, Carmen</creator><creator>Torán-Monserrat, Pere</creator><creator>Caballería, Llorenç</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9865-7427</orcidid><orcidid>https://orcid.org/0000-0003-0667-1609</orcidid><orcidid>https://orcid.org/0000-0002-7990-0719</orcidid></search><sort><creationdate>20210325</creationdate><title>Risk of Liver Fibrosis According to TSH Levels in Euthyroid Subjects</title><author>Martínez-Escudé, Alba ; 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This study aimed to investigate the risk of liver fibrosis according to low-normal thyroid function in the general population. We performed a descriptive cross-sectional study in subjects from 18-75 years randomly selected from 16 primary health care centers from 2017-2019. Each subject underwent clinical evaluation, physical examination, blood analysis and transient hepatic elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with fibrosis. We included 1096 subjects (60 ± 11 years; 61% women); 70% had strict-normal thyroid function and 30% had low-normal thyroid function. Low-normal thyroid function was associated with a higher liver stiffness (LS) values: 5.2 vs. 4.8 kPa (
= 0.001) and a greater prevalence of fibrosis: 6.1 vs. 3% (
= 0.016) and 4.3 vs. 2.1% (
= 0.044) for the cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively. After adjustment for potential confounding factors, the risk of fibrosis in subjects with low-normal thyroid function was OR 1.54 (
= 0.213). In conclusion, low-normal thyroid function is associated with higher LS values and a greater risk of liver fibrosis in the general population, being dependent on other metabolic factors.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33805893</pmid><doi>10.3390/jcm10071350</doi><orcidid>https://orcid.org/0000-0002-9865-7427</orcidid><orcidid>https://orcid.org/0000-0003-0667-1609</orcidid><orcidid>https://orcid.org/0000-0002-7990-0719</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Age Alcohol use Blood platelets Blood pressure Body mass index Clinical medicine Diabetes High density lipoprotein Hypothyroidism Laboratories Liver diseases Normal distribution Obesity Population Serology Thyroid gland Variables Womens health |
| title | Risk of Liver Fibrosis According to TSH Levels in Euthyroid Subjects |
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