Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects
Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC ri...
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| Veröffentlicht in: | International journal of molecular sciences 2021-03, Vol.22 (7), p.3510 |
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| description | Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited. In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets. |
| doi_str_mv | 10.3390/ijms22073510 |
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In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22073510</identifier><identifier>PMID: 33805295</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Anticarcinogenic Agents - therapeutic use ; Antineoplastic Agents - therapeutic use ; Antioxidants ; Apoptosis ; Bladder cancer ; Cancer ; Cancer research ; Cell Differentiation ; Clinical trials ; Connective tissue ; Dehydrogenases ; Epidemiology ; Gene expression ; Humans ; Liver ; Metabolism ; Metabolites ; Metastasis ; Morbidity ; Proteins ; Retinene ; Retinoic acid ; Retinoids ; Retinoids - metabolism ; Retinoids - pharmacology ; Retinoids - therapeutic use ; Review ; Signal Transduction ; Therapeutic targets ; Tumors ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - metabolism ; Urinary Bladder Neoplasms - physiopathology ; Urinary Bladder Neoplasms - prevention & control ; Vitamin A ; Vitamin A - metabolism ; Vitamin A - pharmacology ; Vitamin A - therapeutic use</subject><ispartof>International journal of molecular sciences, 2021-03, Vol.22 (7), p.3510</ispartof><rights>2021 by the authors. 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Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited. In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - therapeutic use</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cell Differentiation</subject><subject>Clinical trials</subject><subject>Connective tissue</subject><subject>Dehydrogenases</subject><subject>Epidemiology</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metastasis</subject><subject>Morbidity</subject><subject>Proteins</subject><subject>Retinene</subject><subject>Retinoic acid</subject><subject>Retinoids</subject><subject>Retinoids - metabolism</subject><subject>Retinoids - pharmacology</subject><subject>Retinoids - therapeutic use</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>Therapeutic targets</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary Bladder Neoplasms - physiopathology</subject><subject>Urinary Bladder Neoplasms - prevention & control</subject><subject>Vitamin A</subject><subject>Vitamin A - metabolism</subject><subject>Vitamin A - pharmacology</subject><subject>Vitamin A - therapeutic use</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1v1DAQhiMEoqVw44wsceHQBX_EscMBqaxaQKoAocLV8sek9Sqxt7YTxL_gJ-NtS7VwGmvm0aMZv03znODXjPX4jd9MmVIsGCf4QXNIWkpXGHfi4d77oHmS8wZjyijvHzcHjEnMac8Pm98_fNGTD-gE6eDQNyg-RO8yqq33o3YOElrrYHflCqa4TbBAKD6GG_4igS5Tbbytgs86JV38AlWzePiJ4oDWc0p1jE4X76BqjqtGjyOES8g3hrO5zAnQ1xTzFmzJT5tHgx4zPLurR833s9OL9cfV-ZcPn9Yn5yvbElpWxhLWW6H7jvCBSeCGd8JRYUhvuBGtwMw5THo5sMFIzbUcJAhrOgO7cceOmne33u1sJnC2Lpn0qLbJTzr9UlF79e8k-Ct1GRclMeuEFFXw6k6Q4vUMuajJZwvjqAPEOSvKseQd67u2oi__QzdxTqGeV6lWCoEFlpU6vqVs_YucYLhfhmC1i1rtR13xF_sH3MN_s2V_ADghpuQ</recordid><startdate>20210329</startdate><enddate>20210329</enddate><creator>Tratnjek, Larisa</creator><creator>Jeruc, Jera</creator><creator>Romih, Rok</creator><creator>Zupančič, Daša</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9598-3561</orcidid><orcidid>https://orcid.org/0000-0003-1368-0554</orcidid><orcidid>https://orcid.org/0000-0001-9492-5706</orcidid><orcidid>https://orcid.org/0000-0001-9173-0137</orcidid></search><sort><creationdate>20210329</creationdate><title>Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects</title><author>Tratnjek, Larisa ; 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In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33805295</pmid><doi>10.3390/ijms22073510</doi><orcidid>https://orcid.org/0000-0001-9598-3561</orcidid><orcidid>https://orcid.org/0000-0003-1368-0554</orcidid><orcidid>https://orcid.org/0000-0001-9492-5706</orcidid><orcidid>https://orcid.org/0000-0001-9173-0137</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anticarcinogenic Agents - therapeutic use Antineoplastic Agents - therapeutic use Antioxidants Apoptosis Bladder cancer Cancer Cancer research Cell Differentiation Clinical trials Connective tissue Dehydrogenases Epidemiology Gene expression Humans Liver Metabolism Metabolites Metastasis Morbidity Proteins Retinene Retinoic acid Retinoids Retinoids - metabolism Retinoids - pharmacology Retinoids - therapeutic use Review Signal Transduction Therapeutic targets Tumors Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - physiopathology Urinary Bladder Neoplasms - prevention & control Vitamin A Vitamin A - metabolism Vitamin A - pharmacology Vitamin A - therapeutic use |
| title | Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects |
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