Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease

Chagas disease, caused by the parasite ( ), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense cardiac fibrosis and inflammation are hallmarks of chronic Chagas disease cardiomyopathy (CCC). Previously, we identified upregulation of circul...

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Veröffentlicht in:	International journal of molecular sciences 2021-03, Vol.22 (7), p.3307
Hauptverfasser:	Nonaka, Carolina Kymie Vasques, Sampaio, Gabriela Louise, Silva, Katia Nunes, Khouri, Ricardo, Macedo, Carolina Thé, Chagas Translational Research Consortium, Rogatto, Silvia Regina, Ribeiro Dos Santos, Ricardo, Souza, Bruno Solano de Freitas, Soares, Milena Botelho Pereira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomyopathy Cell cycle Cell growth Cells, Cultured Chagas Cardiomyopathy - genetics Chagas Cardiomyopathy - metabolism Chagas Cardiomyopathy - pathology Chagas Cardiomyopathy - therapy Chagas disease Collagen Collagen - genetics Collagen - metabolism Datasets Extracellular matrix Fibroblasts Fibrosis Gene expression Growth factors Humans Infections Inflammation Inflammatory response Male Mice Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA Myocytes, Cardiac - metabolism Myofibroblasts - metabolism Nucleic acids Parasites Pathogenesis Protozoa Public health RNAi Therapeutics - methods Therapeutic targets Transforming growth factor-b1 Trypanosoma cruzi Tumor necrosis factor-TNF Up-Regulation
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