Characterization of glycoprotein IIb/IIIa‐specific alloantibodies induced by cross‐strain platelet immunization in mice

Background We previously described a mouse model in which platelet immunization between selected strains leads to production of alloantibodies and severe autoimmune thrombocytopenia and mimics the human condition posttransfusion purpura (PTP). This report describes studies defining epitopes recogniz...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2021-04, Vol.61 (4), p.1278-1285
Hauptverfasser:	Bougie, Daniel W., Sutton, Jessica, Aster, Richard H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloantibodies alloantibody Amino acids Antigens Binding Epitopes FNAIT Glycoproteins Immunization Immunogenicity Immunoprecipitation Monoclonal antibodies platelet antigen platelet refractoriness Platelets PTP Purpura Spleen Target recognition Thrombocytopenia
Online-Zugang:	Volltext
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