Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals

Autophagy maintains cellular homeostasis and its dysfunction has been implicated in aging. Bats are the longest-lived mammals for their size, but the molecular mechanisms underlying their extended healthspan are not well understood. Here, drawing on >8 years of mark-recapture field studies, we re...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2021-03, Vol.13 (6), p.7998-8025
Hauptverfasser:	Kacprzyk, Joanna, Locatelli, Andrea G, Hughes, Graham M, Huang, Zixia, Clarke, Michael, Gorbunova, Vera, Sacchi, Carlotta, Stewart, Gavin S, Teeling, Emma C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Animals Autophagy - genetics Biological Evolution Chiroptera - genetics Fibroblasts - metabolism Longevity - genetics Mice Research Paper Transcriptome
Online-Zugang:	Volltext
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