Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents

Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effect...

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Veröffentlicht in:Science advances 2021-04, Vol.7 (15)
Hauptverfasser: Wiers, Corinde E, Vendruscolo, Leandro F, van der Veen, Jan-Willem, Manza, Peter, Shokri-Kojori, Ehsan, Kroll, Danielle S, Feldman, Dana E, McPherson, Katherine L, Biesecker, Catherine L, Zhang, Rui, Herman, Kimberly, Elvig, Sophie K, Vendruscolo, Janaina C M, Turner, Sara A, Yang, Shanna, Schwandt, Melanie, Tomasi, Dardo, Cervenka, Mackenzie C, Fink-Jensen, Anders, Benveniste, Helene, Diazgranados, Nancy, Wang, Gene-Jack, Koob, George F, Volkow, Nora D
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container_issue 15
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container_title Science advances
container_volume 7
creator Wiers, Corinde E
Vendruscolo, Leandro F
van der Veen, Jan-Willem
Manza, Peter
Shokri-Kojori, Ehsan
Kroll, Danielle S
Feldman, Dana E
McPherson, Katherine L
Biesecker, Catherine L
Zhang, Rui
Herman, Kimberly
Elvig, Sophie K
Vendruscolo, Janaina C M
Turner, Sara A
Yang, Shanna
Schwandt, Melanie
Tomasi, Dardo
Cervenka, Mackenzie C
Fink-Jensen, Anders
Benveniste, Helene
Diazgranados, Nancy
Wang, Gene-Jack
Koob, George F
Volkow, Nora D
description Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD ( = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet ( = 14). Over a 3-week treatment, KD compared to SA showed lower "wanting" and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.
doi_str_mv 10.1126/sciadv.abf6780
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SciAdv r-articles
title Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
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