Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020
Mortality is an important measure of the severity of a pandemic. This study aimed to understand how mortality by age of hospitalized patients who were tested for SARS-CoV-2 has changed over time. To evaluate trends in in-hospital mortality among patients who tested positive for SARS-CoV-2. This retr...
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| Veröffentlicht in: | JAMA network open 2021-04, Vol.4 (4), p.e216556-e216556 |
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| creator | Finelli, Lyn Gupta, Vikas Petigara, Tanaz Yu, Kalvin Bauer, Karri A Puzniak, Laura A |
| description | Mortality is an important measure of the severity of a pandemic. This study aimed to understand how mortality by age of hospitalized patients who were tested for SARS-CoV-2 has changed over time.
To evaluate trends in in-hospital mortality among patients who tested positive for SARS-CoV-2.
This retrospective cohort study included patients who were hospitalized for at least 1 day at 1 of 209 US acute care hospitals of variable size, in urban and rural areas, between March 1 and November 21, 2020. Eligible patients had a SARS-CoV-2 polymerase chain reaction (PCR) or antigen test within 7 days of admission or during hospitalization, and a record of discharge or in-hospital death.
SARS-CoV-2 positivity.
SARS-CoV-2 infection was defined as a positive SARS-CoV-2 PCR or antigen test within 7 days before admission or during hospitalization. Mortality was extracted from electronically available data.
Among 503 409 admitted patients, 42 604 (8.5%) had SARS-CoV-2-positive tests. Of those with SARS-CoV-2-positive tests, 21 592 (50.7%) were male patients. Hospital admissions among patients with SARS-CoV-2-positive tests were highest in the group aged 65 years or older (19 929 [46.8%]), followed by those aged 50 to 64 years (11 602 [27.2%]) and 18 to 49 years (10 619 [24.9%]). Hospital admissions among patients 18 to 49 years of age increased from 1099 of 5319 (20.7%) in April to 1266 of 4184 (30.3%) in June and 2156 of 7280 (29.6%) in July, briefly exceeding those in the group 50 to 64 years of age (June: 1194 of 4184 [28.5%]; 2039 of 7280 [28.0%]). Patients with SARS-CoV-2-positive tests had higher in-hospital mortality than patients with SARS-CoV-2-negative tests (4705 [11.0%] vs 11 707 of 460 805 [2.5%]; P |
| doi_str_mv | 10.1001/jamanetworkopen.2021.6556 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8033442</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2667849629</sourcerecordid><originalsourceid>FETCH-LOGICAL-a470t-f14f85ec80252d370bf00de91f3876efd181a4915cf4fddbf6d53b864937e45b3</originalsourceid><addsrcrecordid>eNpdkctuFDEQRS0EIlHILyAjNmx6KD_bvUEajYAEJQIxBJaWu9tOPHTbg-0Bha_HozwUsqqS6tbVrToIvSKwIADk7cbMJtjyJ6afcWvDggIlCymEfIIOqWh5wxSIpw_6A3Sc8wYAKBDWSfEcHTCmGFAqD9Gn85iKmXy5xss5hkt8scZfTPE2lIxPYt76_fSvHfEPX67wevl13azi94bi0-DsUHwM2AdcQ8AL9MyZKdvj23qELj68_7Y6ac4-fzxdLc8aw1sojSPcKWEHBVTQkbXQO4DRdsQx1UrrRqKI4R0Rg-NuHHsnR8F6JXnHWstFz47Quxvf7a6f7TjUqMlMepv8bNK1jsbr_yfBX-nL-FsrYIxzWg3e3Bqk-Gtnc9Gzz4OdpvrXuMuaClKziU5Alb5-JN3EXQr1PE2lbBXvJO2qqrtRDSnmnKy7D0NA76HpR9D0HpreQ6u7Lx9ec795h4j9A_qKlps</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2667849629</pqid></control><display><type>article</type><title>Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Finelli, Lyn ; Gupta, Vikas ; Petigara, Tanaz ; Yu, Kalvin ; Bauer, Karri A ; Puzniak, Laura A</creator><creatorcontrib>Finelli, Lyn ; Gupta, Vikas ; Petigara, Tanaz ; Yu, Kalvin ; Bauer, Karri A ; Puzniak, Laura A</creatorcontrib><description>Mortality is an important measure of the severity of a pandemic. This study aimed to understand how mortality by age of hospitalized patients who were tested for SARS-CoV-2 has changed over time.
To evaluate trends in in-hospital mortality among patients who tested positive for SARS-CoV-2.
This retrospective cohort study included patients who were hospitalized for at least 1 day at 1 of 209 US acute care hospitals of variable size, in urban and rural areas, between March 1 and November 21, 2020. Eligible patients had a SARS-CoV-2 polymerase chain reaction (PCR) or antigen test within 7 days of admission or during hospitalization, and a record of discharge or in-hospital death.
SARS-CoV-2 positivity.
SARS-CoV-2 infection was defined as a positive SARS-CoV-2 PCR or antigen test within 7 days before admission or during hospitalization. Mortality was extracted from electronically available data.
Among 503 409 admitted patients, 42 604 (8.5%) had SARS-CoV-2-positive tests. Of those with SARS-CoV-2-positive tests, 21 592 (50.7%) were male patients. Hospital admissions among patients with SARS-CoV-2-positive tests were highest in the group aged 65 years or older (19 929 [46.8%]), followed by those aged 50 to 64 years (11 602 [27.2%]) and 18 to 49 years (10 619 [24.9%]). Hospital admissions among patients 18 to 49 years of age increased from 1099 of 5319 (20.7%) in April to 1266 of 4184 (30.3%) in June and 2156 of 7280 (29.6%) in July, briefly exceeding those in the group 50 to 64 years of age (June: 1194 of 4184 [28.5%]; 2039 of 7280 [28.0%]). Patients with SARS-CoV-2-positive tests had higher in-hospital mortality than patients with SARS-CoV-2-negative tests (4705 [11.0%] vs 11 707 of 460 805 [2.5%]; P < .001). In-hospital mortality rates increased with increasing age for both patients with SARS-CoV-2-negative tests and SARS-CoV-2-positive tests. In patients with SARS-CoV-2-negative tests, mortality increased from 45 of 11 255 (0.4%) in those younger than 18 years to 4812 of 107 394 (4.5%) in those older than 75 years. In patients with SARS-CoV-2-positive tests, mortality increased from 1 of 454 (0.2%) of those younger than 18 years to 2149 of 10 287 (20.9%) in those older than 75 years. In-hospital mortality rates among patients with SARS-CoV-2-negative tests were similar for male and female patients (6273 of 209 086 [3.0%] vs 5538 of 251 719 [2.2%]) but higher mortality was observed among male patients with SARS-CoV-2-positive tests (2700 of 21 592 [12.5%]) compared with female patients with SARS-CoV-2-positive tests (2016 of 21 012 [9.60%]). Overall, in-hospital mortality increased from March to April (63 of 597 [10.6%] to 1047 of 5319 [19.7%]), then decreased significantly to November (499 of 5350 [9.3%]; P = .04), with significant decreases in the oldest age groups (50-64 years: 197 of 1542 [12.8%] to 73 of 1341 [5.4%]; P = .02; 65-75 years: 269 of 1182 [22.8%] to 137 of 1332 [10.3%]; P = .006; >75 years: 535 of 1479 [36.2%] to 262 of 1505 [17.4%]; P = .03).
This nationally representative study supported the findings of smaller, regional studies and found that in-hospital mortality declined across all age groups during the period evaluated. Reductions were unlikely because of a higher proportion of younger patients with lower in-hospital mortality in the later period.</description><identifier>ISSN: 2574-3805</identifier><identifier>EISSN: 2574-3805</identifier><identifier>DOI: 10.1001/jamanetworkopen.2021.6556</identifier><identifier>PMID: 33830226</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adolescent ; Adult ; Age groups ; Aged ; Aged, 80 and over ; Antigens ; COVID-19 - mortality ; Female ; Hospital Mortality - trends ; Hospitalization ; Humans ; Infectious Diseases ; Male ; Middle Aged ; Mortality ; Online Only ; Original Investigation ; Patient admissions ; Retrospective Studies ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; United States - epidemiology ; Young Adult</subject><ispartof>JAMA network open, 2021-04, Vol.4 (4), p.e216556-e216556</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2021 Finelli L et al. .</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a470t-f14f85ec80252d370bf00de91f3876efd181a4915cf4fddbf6d53b864937e45b3</citedby><cites>FETCH-LOGICAL-a470t-f14f85ec80252d370bf00de91f3876efd181a4915cf4fddbf6d53b864937e45b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33830226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finelli, Lyn</creatorcontrib><creatorcontrib>Gupta, Vikas</creatorcontrib><creatorcontrib>Petigara, Tanaz</creatorcontrib><creatorcontrib>Yu, Kalvin</creatorcontrib><creatorcontrib>Bauer, Karri A</creatorcontrib><creatorcontrib>Puzniak, Laura A</creatorcontrib><title>Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020</title><title>JAMA network open</title><addtitle>JAMA Netw Open</addtitle><description>Mortality is an important measure of the severity of a pandemic. This study aimed to understand how mortality by age of hospitalized patients who were tested for SARS-CoV-2 has changed over time.
To evaluate trends in in-hospital mortality among patients who tested positive for SARS-CoV-2.
This retrospective cohort study included patients who were hospitalized for at least 1 day at 1 of 209 US acute care hospitals of variable size, in urban and rural areas, between March 1 and November 21, 2020. Eligible patients had a SARS-CoV-2 polymerase chain reaction (PCR) or antigen test within 7 days of admission or during hospitalization, and a record of discharge or in-hospital death.
SARS-CoV-2 positivity.
SARS-CoV-2 infection was defined as a positive SARS-CoV-2 PCR or antigen test within 7 days before admission or during hospitalization. Mortality was extracted from electronically available data.
Among 503 409 admitted patients, 42 604 (8.5%) had SARS-CoV-2-positive tests. Of those with SARS-CoV-2-positive tests, 21 592 (50.7%) were male patients. Hospital admissions among patients with SARS-CoV-2-positive tests were highest in the group aged 65 years or older (19 929 [46.8%]), followed by those aged 50 to 64 years (11 602 [27.2%]) and 18 to 49 years (10 619 [24.9%]). Hospital admissions among patients 18 to 49 years of age increased from 1099 of 5319 (20.7%) in April to 1266 of 4184 (30.3%) in June and 2156 of 7280 (29.6%) in July, briefly exceeding those in the group 50 to 64 years of age (June: 1194 of 4184 [28.5%]; 2039 of 7280 [28.0%]). Patients with SARS-CoV-2-positive tests had higher in-hospital mortality than patients with SARS-CoV-2-negative tests (4705 [11.0%] vs 11 707 of 460 805 [2.5%]; P < .001). In-hospital mortality rates increased with increasing age for both patients with SARS-CoV-2-negative tests and SARS-CoV-2-positive tests. In patients with SARS-CoV-2-negative tests, mortality increased from 45 of 11 255 (0.4%) in those younger than 18 years to 4812 of 107 394 (4.5%) in those older than 75 years. In patients with SARS-CoV-2-positive tests, mortality increased from 1 of 454 (0.2%) of those younger than 18 years to 2149 of 10 287 (20.9%) in those older than 75 years. In-hospital mortality rates among patients with SARS-CoV-2-negative tests were similar for male and female patients (6273 of 209 086 [3.0%] vs 5538 of 251 719 [2.2%]) but higher mortality was observed among male patients with SARS-CoV-2-positive tests (2700 of 21 592 [12.5%]) compared with female patients with SARS-CoV-2-positive tests (2016 of 21 012 [9.60%]). Overall, in-hospital mortality increased from March to April (63 of 597 [10.6%] to 1047 of 5319 [19.7%]), then decreased significantly to November (499 of 5350 [9.3%]; P = .04), with significant decreases in the oldest age groups (50-64 years: 197 of 1542 [12.8%] to 73 of 1341 [5.4%]; P = .02; 65-75 years: 269 of 1182 [22.8%] to 137 of 1332 [10.3%]; P = .006; >75 years: 535 of 1479 [36.2%] to 262 of 1505 [17.4%]; P = .03).
This nationally representative study supported the findings of smaller, regional studies and found that in-hospital mortality declined across all age groups during the period evaluated. Reductions were unlikely because of a higher proportion of younger patients with lower in-hospital mortality in the later period.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age groups</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>COVID-19 - mortality</subject><subject>Female</subject><subject>Hospital Mortality - trends</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Online Only</subject><subject>Original Investigation</subject><subject>Patient admissions</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>2574-3805</issn><issn>2574-3805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkctuFDEQRS0EIlHILyAjNmx6KD_bvUEajYAEJQIxBJaWu9tOPHTbg-0Bha_HozwUsqqS6tbVrToIvSKwIADk7cbMJtjyJ6afcWvDggIlCymEfIIOqWh5wxSIpw_6A3Sc8wYAKBDWSfEcHTCmGFAqD9Gn85iKmXy5xss5hkt8scZfTPE2lIxPYt76_fSvHfEPX67wevl13azi94bi0-DsUHwM2AdcQ8AL9MyZKdvj23qELj68_7Y6ac4-fzxdLc8aw1sojSPcKWEHBVTQkbXQO4DRdsQx1UrrRqKI4R0Rg-NuHHsnR8F6JXnHWstFz47Quxvf7a6f7TjUqMlMepv8bNK1jsbr_yfBX-nL-FsrYIxzWg3e3Bqk-Gtnc9Gzz4OdpvrXuMuaClKziU5Alb5-JN3EXQr1PE2lbBXvJO2qqrtRDSnmnKy7D0NA76HpR9D0HpreQ6u7Lx9ec795h4j9A_qKlps</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Finelli, Lyn</creator><creator>Gupta, Vikas</creator><creator>Petigara, Tanaz</creator><creator>Yu, Kalvin</creator><creator>Bauer, Karri A</creator><creator>Puzniak, Laura A</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210401</creationdate><title>Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020</title><author>Finelli, Lyn ; Gupta, Vikas ; Petigara, Tanaz ; Yu, Kalvin ; Bauer, Karri A ; Puzniak, Laura A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a470t-f14f85ec80252d370bf00de91f3876efd181a4915cf4fddbf6d53b864937e45b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age groups</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>COVID-19 - mortality</topic><topic>Female</topic><topic>Hospital Mortality - trends</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Online Only</topic><topic>Original Investigation</topic><topic>Patient admissions</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finelli, Lyn</creatorcontrib><creatorcontrib>Gupta, Vikas</creatorcontrib><creatorcontrib>Petigara, Tanaz</creatorcontrib><creatorcontrib>Yu, Kalvin</creatorcontrib><creatorcontrib>Bauer, Karri A</creatorcontrib><creatorcontrib>Puzniak, Laura A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA network open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finelli, Lyn</au><au>Gupta, Vikas</au><au>Petigara, Tanaz</au><au>Yu, Kalvin</au><au>Bauer, Karri A</au><au>Puzniak, Laura A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020</atitle><jtitle>JAMA network open</jtitle><addtitle>JAMA Netw Open</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>4</volume><issue>4</issue><spage>e216556</spage><epage>e216556</epage><pages>e216556-e216556</pages><issn>2574-3805</issn><eissn>2574-3805</eissn><abstract>Mortality is an important measure of the severity of a pandemic. This study aimed to understand how mortality by age of hospitalized patients who were tested for SARS-CoV-2 has changed over time.
To evaluate trends in in-hospital mortality among patients who tested positive for SARS-CoV-2.
This retrospective cohort study included patients who were hospitalized for at least 1 day at 1 of 209 US acute care hospitals of variable size, in urban and rural areas, between March 1 and November 21, 2020. Eligible patients had a SARS-CoV-2 polymerase chain reaction (PCR) or antigen test within 7 days of admission or during hospitalization, and a record of discharge or in-hospital death.
SARS-CoV-2 positivity.
SARS-CoV-2 infection was defined as a positive SARS-CoV-2 PCR or antigen test within 7 days before admission or during hospitalization. Mortality was extracted from electronically available data.
Among 503 409 admitted patients, 42 604 (8.5%) had SARS-CoV-2-positive tests. Of those with SARS-CoV-2-positive tests, 21 592 (50.7%) were male patients. Hospital admissions among patients with SARS-CoV-2-positive tests were highest in the group aged 65 years or older (19 929 [46.8%]), followed by those aged 50 to 64 years (11 602 [27.2%]) and 18 to 49 years (10 619 [24.9%]). Hospital admissions among patients 18 to 49 years of age increased from 1099 of 5319 (20.7%) in April to 1266 of 4184 (30.3%) in June and 2156 of 7280 (29.6%) in July, briefly exceeding those in the group 50 to 64 years of age (June: 1194 of 4184 [28.5%]; 2039 of 7280 [28.0%]). Patients with SARS-CoV-2-positive tests had higher in-hospital mortality than patients with SARS-CoV-2-negative tests (4705 [11.0%] vs 11 707 of 460 805 [2.5%]; P < .001). In-hospital mortality rates increased with increasing age for both patients with SARS-CoV-2-negative tests and SARS-CoV-2-positive tests. In patients with SARS-CoV-2-negative tests, mortality increased from 45 of 11 255 (0.4%) in those younger than 18 years to 4812 of 107 394 (4.5%) in those older than 75 years. In patients with SARS-CoV-2-positive tests, mortality increased from 1 of 454 (0.2%) of those younger than 18 years to 2149 of 10 287 (20.9%) in those older than 75 years. In-hospital mortality rates among patients with SARS-CoV-2-negative tests were similar for male and female patients (6273 of 209 086 [3.0%] vs 5538 of 251 719 [2.2%]) but higher mortality was observed among male patients with SARS-CoV-2-positive tests (2700 of 21 592 [12.5%]) compared with female patients with SARS-CoV-2-positive tests (2016 of 21 012 [9.60%]). Overall, in-hospital mortality increased from March to April (63 of 597 [10.6%] to 1047 of 5319 [19.7%]), then decreased significantly to November (499 of 5350 [9.3%]; P = .04), with significant decreases in the oldest age groups (50-64 years: 197 of 1542 [12.8%] to 73 of 1341 [5.4%]; P = .02; 65-75 years: 269 of 1182 [22.8%] to 137 of 1332 [10.3%]; P = .006; >75 years: 535 of 1479 [36.2%] to 262 of 1505 [17.4%]; P = .03).
This nationally representative study supported the findings of smaller, regional studies and found that in-hospital mortality declined across all age groups during the period evaluated. Reductions were unlikely because of a higher proportion of younger patients with lower in-hospital mortality in the later period.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>33830226</pmid><doi>10.1001/jamanetworkopen.2021.6556</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age groups Aged Aged, 80 and over Antigens COVID-19 - mortality Female Hospital Mortality - trends Hospitalization Humans Infectious Diseases Male Middle Aged Mortality Online Only Original Investigation Patient admissions Retrospective Studies SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 United States - epidemiology Young Adult |
| title | Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020 |
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