Control of endothelial quiescence by FOXO-regulated metabolites

Endothelial cells (ECs) adapt their metabolism to enable the growth of new blood vessels, but little is known how ECs regulate metabolism to adopt a quiescent state. Here, we show that the metabolite S -2-hydroxyglutarate ( S -2HG) plays a crucial role in the regulation of endothelial quiescence. We...

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Veröffentlicht in:	Nature cell biology 2021-04, Vol.23 (4), p.413-423
Hauptverfasser:	Andrade, Jorge, Shi, Chenyue, Costa, Ana S. H., Choi, Jeongwoon, Kim, Jaeryung, Doddaballapur, Anuradha, Sugino, Toshiya, Ong, Yu Ting, Castro, Marco, Zimmermann, Barbara, Kaulich, Manuel, Guenther, Stefan, Wilhelm, Kerstin, Kubota, Yoshiaki, Braun, Thomas, Koh, Gou Young, Grosso, Ana Rita, Frezza, Christian, Potente, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 13/95 14/19 38 38/39 38/91 42/41 45 631/136/16 631/443/319/333 631/443/592/16 64/60 82 82/80 96 Amino acids Animals Biomedical and Life Sciences Blood vessels Cancer Research Catabolites Cell Biology Cell cycle Cell metabolism Cell Proliferation - genetics Cell research Chain branching Developmental Biology Endothelial cells Endothelial Cells - metabolism Endothelium Forkhead Box Protein O1 - genetics Forkhead protein FOXO1 protein Gene Expression Regulation - genetics Glutarates - metabolism Health aspects Human Umbilical Vein Endothelial Cells - metabolism Humans Ketoglutaric acid Life Sciences Metabolism Metabolism - genetics Metabolites Mice Mitochondria Neovascularization, Physiologic - genetics Oxoglutarate dehydrogenase (lipoamide) Physiological aspects Proto-Oncogene Proteins c-akt Rarefaction Signal Transduction - genetics Stem Cells Transcription activation Valerates - metabolism
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