Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers

Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers. However, not all patients respond due to intrinsic or acquired resistance to PARP1 inhibitor. Development of alternative synthetic lethality app...

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Veröffentlicht in:	Oncogene 2021-04, Vol.40 (14), p.2496-2508
Hauptverfasser:	Ali, Reem, Alblihy, Adel, Miligy, Islam M., Alabdullah, Muslim L., Alsaleem, Mansour, Toss, Michael S., Algethami, Mashael, Abdel-Fatah, Tarek, Moseley, Paul, Chan, Stephen, Mongan, Nigel P., Narayan, Satya, Rakha, Emad A., Madhusudan, Srinivasan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/106 13/2 13/31 13/51 14/1 14/19 14/34 14/63 38/22 38/23 38/39 38/77 42/109 42/89 45/23 45/41 631/67/1517/1709 692/53/2423 Adenine Apoptosis Base excision repair BRCA2 protein Breast cancer Carcinoma, Ovarian Epithelial - genetics Carcinoma, Ovarian Epithelial - pathology Cell Biology Cell cycle Cell Line, Tumor Deoxyribonucleic acid DNA DNA polymerase DNA Polymerase beta - metabolism DNA repair DNA-directed DNA polymerase Female Human Genetics Humans Internal Medicine Lethality Medicine Medicine & Public Health Mesenchyme NAD Oncology Ovarian cancer Platinum Platinum - metabolism Poly(ADP-ribose) Poly(ADP-ribose) glycohydrolase Poly(ADP-ribose) polymerase Ribose Toxicity Transfection Tumors
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