Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics

Objectives. Oral squamous cell carcinoma (OSCC) is the most common oral cancer and has a poor prognosis. We aimed to identify new biomarkers or potential therapeutic targets for OSCC. Materials and Methods. Four pairs of tumor and adjacent normal tissues were collected from OSCC patients, and differ...

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Veröffentlicht in:	BioMed research international 2021-04, Vol.2021, p.6657767-14
Hauptverfasser:	Zhang, Yang-Yang, Mao, Ming-Hui, Han, Zheng-Xue
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Bioinformatics Biomarkers Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Care and treatment Cluster Analysis Computational Biology CTLA-4 protein Data analysis Diagnosis Encyclopedias Extracellular matrix Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Ontology Gene sequencing Genes Genetic aspects Genetic Association Studies Genomes Genomics Head & neck cancer Humans Logistic Models Male Medical prognosis Methods Middle Aged Mouth cancer Mouth Neoplasms - genetics Mouth Neoplasms - pathology Multivariate Analysis Network analysis Oral cancer Oral squamous cell carcinoma Peptides Prognosis Protein interaction Protein Interaction Maps - genetics Protein-protein interactions Proteins Rank tests Regression analysis Ribonucleic acid Risk factors RNA RNA sequencing ROC Curve Sequence Analysis, RNA Software Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Survival Survival Analysis Therapeutic targets Tongue Transcription, Genetic Tumors Values
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